Conserved Protein Domain Family
MutL

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pfam13941: MutL 
MutL protein
This small family includes, GlmL/MutL from Clostridium tetanomorphum and Clostridium cochlearium. GlmL is located between the genes for the two subunits, epsilon (GlmE) and sigma (GlmS), of the coenzyme-B12-dependent glutamate mutase (methylaspartate mutase), the first enzyme in a pathway of glutamate fermentation. Members shows significant sequence similarity to the hydantoinase branch of the hydantoinase/oxoprolinase family.
Statistics
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PSSM-Id: 493828
Aligned: 63 rows
Threshold Bit Score: 307.161
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_025228683    8 IVATDCGSTTTKAILIERNDttgeYRLVARGEAPTTVErpfEDVTLGVMNSITELEEITettvpagfsagrrvllrdgrv 87  Fimbriimonas g...
CCW35299       16 ILATDCGSTTTKAILIEK-QpdgaYRLICRGEAPTTVEapfDDVTIGVTNAIREVEELcgrrllddgge----------- 83 
CBK42197        8 IVATDCGSTTTKAILIEKvg--eeYRQTYRGEAPTTVEapfEDVTRGVLNAIAEIEELsgrtilegdrii---------- 75 
WP_015424335   11 IVATDCGSTTTKAILIEWid--geFRQTIRGEAPTTVEaplNDVTKGVINATQELEELarlkyhnpnikfm--------- 79  Candidatus Clo...
WP_013109057   21 ILATDCGSTTTKALLIEKid--gvYRQTYRGEAPTTVEeptADVTIGVVNAATEVGELagrqlvdeng------------ 86  Planctopirus l...
WP_013629695   12 ILATDCGSTTTKAILIEKid--geYRQTYRGEAPTTVEepaADVTVGVTNAVAEIGELagrklldeng------------ 77  Rubinisphaera ...
WP_012256160    7 ILAVEIGSLITRVSLIDEvd--geSRLIGQTETLTSRElpyRNVFFAVQEATAQLADLtgrqllrdgr------------ 72  Chloroflexus
WP_025361073    3 LLCLDVGSTWTKAALVGAD-----GALLGTAQHPTTP----PEVLTGIAAVTEELDA----------------------- 50  Kutzneria albida
WP_013677231   10 TVCLDVGSAWTKAVLVRSD-----GTIQGFAEHPTTT----ADVLAGVDAAVGAVTAAAra------------------- 61  Pseudonocardia
jgi:Snas_3947   2 IVCADVGSTYTKVAAVDAET----GRLYGTAAHRTTID---TDVLDGLDAARERVEAELps------------------- 55 
WP_025228683   88 wrqlkqgnrdtsnvggpldSSDLYVSTSSAGGGLQMMVAGVVKAMSAESAERAALGAGAILMDTLSVDDGRRdy------ 161 Fimbriimonas g...
CCW35299       84 ---------pltpqqedgsGVDLYLSTSSAGGGLQMTVIGVVKRMSAESAQRAALGAGAIVIDVLATDDGRKdf------ 148
CBK42197       76 -------tpnqsaqgdpkrGVDIYVSTSSAGGGLQMMVTGVVQNMTGESAQRAALGAGAIVIDVLASNDGRLpy------ 142
WP_015424335   80 ------engefviprkgdvGVDAYVSTSSAGGGLQMMVTGVVASMTGESAERAALGAGAIVMDLIASNDKRMnh------ 147 Candidatus Clo...
WP_013109057   87 ---------llirpargnvGCDAYISTSSAGGGLQMLVCGVVPTMSAASATRAALGAGAIVLETMTSNDRRKph------ 151 Planctopirus l...
WP_013629695   78 ---------qiirpangnvGCDIYISTSSAGGGLQMLVAGVVREMTAASAKRAALGAGAIVMDTLAANDKRKpf------ 142 Rubinisphaera ...
WP_012256160   73 ---------llmpristgdGIDAVIVVTSALEPLRVVVAAIASDVSARSALHAVRGVPSVVLAVVTLDDVSArsttgvmq 143 Chloroflexus
WP_025361073   51 -------------------GDAQVLACSSAGGGLRLAVVGQERLVSAEAGYRVALSAGAKVVHVSAGELDGA-------- 103 Kutzneria albida
WP_013677231   62 ------------------hGEPTVLASSSAGGGLRLVVIGTDALAATEAGHRVARSAGARVVHVHAGALSAE-------- 115 Pseudonocardia
jgi:Snas_3947  56 ------------------gASTELLVCSSAGGGLRLGVIGNEPLVTATAAHRAGLSAGARVVAIISGYIETE-------- 109
WP_025228683  162 ----qKVERLRQLRPDIILMSGGTDGGTKAHLIEMAEVVRRAdpkprfgDM-KLP---IIYAGNKDAAEDVGKVLGES-I 232 Fimbriimonas g...
CCW35299      149 ----eRVERLRQLRPDILLMAGGTDGGTVIHLVEMAEMLLAAdprprlgHNtKLP---VIYAGNPDAYPQVAEILNGH-F 220
CBK42197      143 ----eKIERIRTMRPDMILMSGGTDGGAVTHVVEMAEYIAAAdprprfgSTyRLP---LVYAGNTDARPQIKTILGEK-T 214
WP_015424335  148 ----eKIERIRELRPDMILMAGGEDGGTVKHVVEMAELVASAdpkprlgSGyKLP---VIYAGNKDAREEIVKTLGEK-V 219 Candidatus Clo...
WP_013109057  152 ----dRIQRIRDLRPDMILLAGGTDGGTVRHVAAMAELIAPAkpqprfgGQyKMP---VIYAGNQAAIPVVRDVLGNV-A 223 Planctopirus l...
WP_013629695  143 ----eQIQRIRELRPDMILLAGGTDGGTRKHIVQLAELIAPAkpqprfgEKyRMP---VIYAGNTEAWELVQETFDDD-V 214 Rubinisphaera ...
WP_012256160  144 swlerQLETLLPLLPDVVVLAGGVEGGTVEAMKRLAHLINLKls---ftAAiRQPlptIIYAGNTSVQPQIQAALGGHnC 220 Chloroflexus
WP_025361073  104 -----GIRGLRATRPDLVLLAGGTDGGDTKVLLHNARRLAAN-------RV-KCP---IVLAGNAHAREEATGILAGTgR 167 Kutzneria albida
WP_013677231  116 -----DVRVVRGHRPGALLLIGGADGDDPAVLLHNAGRLARA-------RV-RYP---IVLAGNVAARDDALALLRSTgR 179 Pseudonocardia
jgi:Snas_3947 110 -----AIRKLTTTAPDILLLAGGTDGGDATVLIEHAHTLAAAsas--deRL-RLP---VVLAGNTAAATEVTAILTKAgL 178
WP_025228683  233 QLQVVANLRPTLDRENLGPAREEIHEMFLEHVMqQAPGYSKLLEWT------SEEVMATPNAVGKLLKEYAE--NEKI-- 302 Fimbriimonas g...
CCW35299      221 DLRQVPNLRPSLERENLGPAREAIHEVFLQHVMqQAPGYSKLLNWT------SADIMSTPNAVGKIMQTIAE--QQGI-- 290
CBK42197      215 ALDFADNIRPVLERENLAPARNKIHDLFLEHVMqQAPGYKKLIEMA------GAPIMPTPAAVGVIMETIAK--REGI-- 284
WP_015424335  220 DLIITDNIRPKLEIENLLPAREKIHNLFMEHVMkQAPGYNKLMEWTvgpeheQVPIMPTPAAVGNIMQAIAK--EENI-- 295 Candidatus Clo...
WP_013109057  224 ELSFVENVRPVLEREALAGARDAIHDLFLEHVMaHAPGYDKLIEWA------DTAIMPTPGAVGNILQTIAR--TRGL-- 293 Planctopirus l...
WP_013629695  215 ELSQTENVRPTLDVENLGPARDKIHDLFLEHVMaHAPGYDKLISWT------DAPIMPTPGAVGNILREIAE--RENI-- 284 Rubinisphaera ...
WP_012256160  221 ELITVANVRPALDQEVLTPLRQALLACY-ARQLtDVPGIDQLSAPD------QTTLRTVAESQYVMTRFLAE--RQQQ-- 289 Chloroflexus
WP_025361073  168 TVVPTDNVLPDVGELAPGPARTAIREVFLRHVI-GGKGLSRGPRFR------QLVRAVTPDTVLCGVSRLAAvlAAREdg 240 Kutzneria albida
WP_013677231  180 TVVVCDNVVPKVGTVVAEPARQVVAEMFAGHVV-GVQGPSAAPRFR------RLVRLATPDAVARGVAELARvt------ 246 Pseudonocardia
jgi:Snas_3947 179 HVTAVDNVLPRIGQLNPAPARIALREAFLKHVI-AGKHLSDRESFA------ALVRSATPDAVLSGVEVLAEsh------ 245
WP_025228683  303 --NVLGVDIGGATTDVFSV----------FLAPTGERIYNRTVSANLGMSYSICNVLKEAGVENIARWLpfeiDPAEVRN 370 Fimbriimonas g...
CCW35299      291 --NLLGVDIGGATTDVFSV----------F-----DGHFTRTVSANLGMSYSICNVLAEAKIARICRWLpfpvEPSEVRN 353
CBK42197      285 --NLIGVDIGGATTDVFSV----------F-----NGLFNRTVSANLGMSYSISNVLAEAGLDNIMRWVpftiDEQTLRN 347
WP_015424335  296 --EVVGVDIGGATTDIFSV----------F---TKDFIFNRTVSANLGLSYSISNVLASAGLENIMRWVpfdiDESELRN 360 Candidatus Clo...
WP_013109057  294 --NALGVDIGGATTDVFSV----------F-----SGTFNRTVSANLGMSYSISNVCAEAGFDAILRWVpypeSEKELRN 356 Planctopirus l...
WP_013629695  285 --NAVGVDIGGATTDVFSV----------F-----EGTFNRTVSANLGMSYSISNVCAEATMENILRWVhlemNERELRN 347 Rubinisphaera ...
WP_012256160  290 --AVLYVDVGATTTTLIAA----------A-----PDQIAATLHGVCGTAFGVGALLSEVGPAAIARWLpfaiEEQELIE 352 Chloroflexus
WP_025361073  241 agAVLVVDVGGATTDVYSAvstv--ddeaLARTVALPADRRTVEGDLGMRWSAPTVVSEAGVERLAPLe----ELAPLAT 314 Kutzneria albida
WP_013677231  247 ggRVLLVDVGSATTSVHLA--------------DPDGEASRTVEGDLGMRSAATGVLTEGQAEGLVDPv----EADLLGP 308 Pseudonocardia
jgi:Snas_3947 246 -gDLVVVDVGGATTDVYSVltpdaelsgpRREVAGTAWRSRTVEGDLGLRHTAPGIVAAAETEALLEPg----EAEPLRE 320
WP_025228683  371 RLRNKMIRPTTIPQTYEDLLIEHAVSREALRLAFEHHKSLARGL---TGSAQQRDVgqifdqqasgqtlvkmMELDMVIG 447 Fimbriimonas g...
CCW35299      354 QLRNKMIRPTTIPQLLTDLLLEQAVCREALALAFEHHKSLARDL---FGVAQAKNVgqifeqkt-sksfinsLDLDMIVG 429
CBK42197      348 RIKNKMVRPTTIPQSLDELQIEHAIAREALRLALIHHKSLATGL---KGIQQERTIsdvfeqrtsgktlidlLKLDLIVG 424
WP_015424335  361 MIKNKMIRPTTIPSLLEELVLEQAIAKEALRLAFEQHKSFASSL---KGMQKQRDIseafsqsvsgetivnmMTLDLLVG 437 Candidatus Clo...
WP_013109057  357 RVKNKMIRPTTIPQTMEALIFEQAVAREALRLAYVQHKQFATTL---AGVQQQRTIgdafaqsggqqtivnnLKLDLIVG 433 Planctopirus l...
WP_013629695  348 RVKNKMIRPTTIPQTLEALVFEQAVAREALRLAYLQHKEFATTL---KGVQQQRTVgdlfvqdssgasivnnMTLDLLVA 424 Rubinisphaera ...
WP_012256160  353 RLLNRMLRPQTLPATREDCYLDLALAREALALG----------------------Vaalrd-------eqtpLAYERLLA 403 Chloroflexus
WP_025361073  315 QAEFRAGSVDWVPSDVDGAEVDAVLAGLAAVLAVRRHLRMVDGQ---LGp----------------------KGAGLLVL 369 Kutzneria albida
WP_013677231  309 AVERMAAEPGWVPRDAGGAAEDRRIAALAASVAVRRHLAAAPPD---AA-----------------------RPPGLVVL 362 Pseudonocardia
jgi:Snas_3947 321 AAARRAEAPSWLPDTAAEIAVDLRLTRLAITIALRRHARGERlggpqapLRGGKDL----------------RQVSYVIG 384
WP_025228683  448 SGGVLSHAPRR--AQSALMMMDA-----YQP--EGv-----TMLTVDSIFMMPHLGVLSE-HLYEAAKQVFERDC 507 Fimbriimonas ginsen...
CCW35299      430 SGGVLSHAPLR--AQAALMMLDA-----FQP--EGf-----TLLTVDSIFMMPQLGVLST-LHPEAATHVFQRDC 489
CBK42197      425 SGGILSHAPRR--IQSMLMMVDA-----YEP--LGv-----TTLSVDSIFMMPHLGVLST-VNEQAATDVFIRDC 484
WP_015424335  438 SGGVLSHAPRR--NQTVMMLIDA-----FLP--EGi-----TRLSVDSIFMMPHLGVLSE-ISTKAATEVFRKDC 497 Candidatus Cloacimo...
WP_013109057  434 SGGVLSHAPRM--EQTTMMMIDA-----FEP--EGi-----TVLAKDSIFMMPHLGVLAE-IHPQAAMDVFERDC 493 Planctopirus limnop...
WP_013629695  425 SGGVLSHAPRM--EQTAAMLIDA-----FEP--EGy-----TTLAKDSIFMMPHLGVLAQ-VHSQAALEVFERDC 484 Rubinisphaera brasi...
WP_012256160  404 GGGVLTHAPHP--GMALLALLDG-----LQP--ANelpgllLPIHLDMLSLLSVCGGIAA-LSTDAAISIFDHDL 468 Chloroflexus
WP_025361073  370 SGGVFRHAGAErlARIEQRLRAdp---vLRPvlRN------AEIVIDNRYVLAPAGLLAGaGHEAAADSllgahf 435 Kutzneria albida
WP_013677231  363 SGGVFRQRDHGglRAVVATLRAda---vLAPvlDG------ARVVVDNDIVLAPAGLLAAdGRADVAEALLQdhv 428 Pseudonocardia
jgi:Snas_3947 385 SGGVLRNHGAAagEALRQAVCGDtaggyPLP--EN------PVTVIDTSYVLGAAGLLAH-HHPDLAATLLDRHL 450
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