2ZXI,3CP2,3CP8


Conserved Protein Domain Family
SAM_GIDA_C

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pfam13932: SAM_GIDA_C (This model is not part of the current CDD release)
tRNA modifying enzyme MnmG/GidA C-terminal helical bundle
The GidA associated domain is a domain that has been identified at the C-terminus of protein GidA. It consists of several helices, last three being rather short and forming small bundle and are represented in this entry. GidA is a tRNA modification enzyme found in bacteria and mitochondrial. Based on mutational analysis the C-terminal helices have been suggested to be implicated in binding of the D-stem of tRNA and, specifically this domain, to be responsible for the interaction with protein MnmE. Structures of GidA in complex with either tRNA or MnmE are missing. Reported to bind to Pfam family MnmE, pfam12631.
Statistics
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PSSM-Id: 521000
Aligned: 742 rows
Threshold Bit Score: 50.8093
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZXI_A       574 EK-LKKLEDTKIPPDIDYDKIPGL--TKEAREKLKKFKPITVGQASRIDGITPAAITALL 630 Aquifex aeolicus
Q5A7B1       610 NT-FESLDMYKLPQNFTYDNSGSLkiSHEVCTILNIVQPTTIGQAQSLQGITPTAINELK 668 Candida albicans
XP_002549681 610 EK-FEDYDKFILPQNFNYTNTGNLkiSHEVCSILNVIQPSTLGQAMKLRGVTPTAIMELR 668
EMG45580     609 NK-FQDYEKFILPQNFNYTNTGKLkiSHEVCSILNLVQPTTIGQAMKLRGVTPTSIMELR 667
XP_001485404 627 RA-YKADENLLLPKNFVYNNEGNLkiSYEVCHLLNTIQPKTIGQARRIQGVTPAAIFELF 685
XP_013025884 582 KLlYYRDESTVIPSDFDFEKLQSI--SAEELTLLKTIRPVTIGQLKRIQGIKPSTVIYMF 639
O13670       575 KQlNCRDESTVIPSDFDFDTLHSV--SAEELMLLKTIRPATIGQLKRIQGIKPGTIIRLL 632 Schizosaccharomyces pombe 972h-
XP_002175477 589 RFlNFREEATIIPNDVDYTAIGGI--STEEINLLQCIKPSSLAQLKQISGIKPGTIIRLL 646
CCJ30261     610 RFlLLKDEEYIFPPDINYNTLKSL--SSEEKELLNFIRPQSLAQAKRIQGITPSTQLVLL 667
EEQ41754     591 KA-FEADENLLLPMDYTYTNTGNVklSHEVCHLLNTIQPRTIGQARRIQGVTPAALFELF 649 Clavispora lusitaniae ATCC 42720
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