Conserved Protein Domain Family
ASXH
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pfam13919: ASXH (This model is not part of the current CDD release)
Asx homology domain
A conserved alpha helical domain with a characteristic LXXLL motif. The LXXLL motif is detected in diverse transcription factors, coactivators and corepressors and is implicated in mediating interactions between them. The ASXH domain is found in animals, fungi and plants and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs.
Links
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Statistics
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PSSM-Id: 520994
Aligned: 55 rows
Threshold Bit Score: 95.7806
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EPS93753       39 KAQAPEkSAGE-RLEYLLTHPRSKLTKVDISDVLSYANFLDLSPESQQLLVAFLpPTAFAafspsvplthvdySPLqreg 117 
XP_008192914  110 LSTAAQlEQTK-EGCIDLETPDSILVNTNLRLLLNKATFASLPLLYQNKLVQLL-PDVDR--------------NN---- 169 
6_pfamImport    1 LSAAAQlEQTK-EGCVDLETPDSILVNTNLRSLLNKHTFSSLPPLYQYKLLQLL-PHVDR--------------I----- 59  
2_pfamImport    1 LSAAAQlQQAKaEGCVDLETPDSILAQVNLRSLLNKQTFSMLPRLYQHKLVQML-PHVDR--------------ESl--- 62  
XP_002423591  106 MSTAAQlEQTK-EGCIDLETPDSILSNTDLRALLNKHTFSILPPLYQYKLVQLL-PEVDR--------------PN---- 165 
XP_046439374  124 LSAAAQiQRAQ-EGCVDLQNPSSILAKANLRGILNKHTFGSLPPLYQHKLVQLL-PEVDRcpdg---------------- 185 
XP_002114282  111 ASPAVQlKRLS-NGSIDLETPSSILVHTDLKGIISEATFEKLPLTHQYQLLKLL-PEVDR-------------------- 168 
XP_015793626   68 CSASSQiAETR--EKIDITTPDSIFVNTNLKDIINKATFNSLPLFYQYKLVQML-PKCDQ-------------Ittseg- 130 
XP_023208996  226 RLSAGQiKRTK--CKIDVETPDSILVNTNLRALINKHTFSVLPPDCQQKLVKLL-PEVDR-------------------- 282 
7_pfamImport    1 PDAAGSmKRTR-GVEVDFETPGSILVNTNIRALINTRTFAAFPPHCQQQLLLLL-PEVDR-------------------- 58  

EPS93753      118 teaapadedcMDvdapqagsglpqgtqeRTPATldpavfTSPFFLSAARTYQDHLFSGWF------GKKAREEVaqfESG 191 
XP_008192914  170 ----------SVtnstd-------slelSNSGL------NNEFFARACVEWQDRLAEGEFtpenqqKLKLEADK---ERS 223 
6_pfamImport   60 -----------Pvqsda-------mfrlSGSGL------NNEFFARACLDWKERLAEGEFtpesqaKLKAEQEK---EKS 112 
2_pfamImport   63 ----------SDtqsdf-------rpllNSSVL------NNEFFAQACLEWTDRLSEGEFtpenqqKMKMDIDR---EKS 116 
XP_002423591  166 ----------IVaqpds-------slrlNNSAL------NNEFFARACQKWRERLSEGEFtpenqqKLKTESER---EKS 219 
XP_046439374  186 ------------------------ssklSSTAL------SNEFFGRACQKWRDRLAAGEFtpesqqKIRAEAER---DKG 232 
XP_002114282  169 -----------Evtqnn-------qlrlSSSCL------SNEFFNSACLEWRLKLSEGEFtpktkaKVKQQAKK---MA- 220 
XP_015793626  131 ------------------------wtkmSSTAL------RNEFFNRAVKSWSDRLKDGKLtpeflvRWRNEILK---ESS 177 
XP_023208996  283 -----------Qacldg-------llkvTSSAL------NNEFFASAAQSWKERLAEGEFtpelqvRMRQEIEK---EK- 334 
7_pfamImport   59 -----------Qvgpdg-------larlSSSAL------NNEFFAHASQCWKERLGEGEFthemqaRFRQEMEK---EK- 110 

EPS93753      192 VRDgilhaPWKDEVWERDHRP 212 
XP_008192914  224 KLD-----PWKLKHFEPIWGD 239 
6_pfamImport  113 KLD-----PWKLKHFEPLWGE 128 
2_pfamImport  117 KLD-----PFKLKYFEPIWGE 132 
XP_002423591  220 KID-----PWKLKHFEPIWGF 235 
XP_046439374  233 KLD-----PWKVKHFEPFWGT 248 
XP_002114282  221 KLD-----PWKKENFEMSWGD 236 
XP_015793626  178 KLD-----PWKAKHFERVWGE 193 
XP_023208996  335 KVE-----HWKEAFFENYYGE 350 
7_pfamImport  111 KVE-----PWKEKFFEDYYGQ 126
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