Conserved Protein Domain Family
Phostensin_N
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pfam13916: Phostensin_N (This model is not part of the current CDD release)
PP1-regulatory protein, Phostensin N-terminal
Phostensin has been identified as a PP1 regulatory protein binding protein. This domain is N-terminal to the PP1- and SH3-binding regions though may carry an additional SH3-binding motif. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends.
Links
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Statistics
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PSSM-Id: 520993
Aligned: 5 rows
Threshold Bit Score: 75.6473
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_001119759  28 AERDRLSqMPAWKRGILERRRAKLGLPPGEGSPvpGNAEagPPDPDESSVLLEAIGPVHQNRFIQQERQRQQq----QQQ 103 
XP_003794855   8 GPGPRTA-LPAWKREVLERKRAKLAALGGGADPggGAAE--PAGAAERCVLADSLGPLRENPFMRLESERRR-----SAA 79  
Q4KMQ1         8 GSGPRAA-VPAWKREILERKRAKLAALGGGAGP--GAAE--P----EQRVLAESLGPLRENPFMLLEAERRRg----GGA 74   human
A2AI08         8 DPGPRTV-MPAWKREILERRRAKLAALSGGQGS--GAA---PDGPNERLVLAESLGPLSQNPFMRLESERRR-----GTR 76   house mouse
XP_014347164  57 aflkghrewshtdkprnispvrnrldlseskpnrdckesfhpAEETENLVLRESIGPIHENPFIKLEKERRRrkarnASK 136  coelacanth

NP_001119759 104 QRNEVLGDRKAGP 116 
XP_003794855  80 GARPLLEHYRHVP 92  
Q4KMQ1        75 AGARLLERYRRVP 87   human
A2AI08        77 PAQQLLELYCRVP 89   house mouse
XP_014347164 137 PIQQILEMYNNVP 149  coelacanth
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