Conserved Protein Domain Family
Phostensin
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pfam13914: Phostensin (This model is not part of the current CDD release)
Phostensin PP1-binding and SH3-binding region
Phostensin has been identified as a PP1 regulatory protein binding PP1 at the KISF motif. The domain also appears to carry an incomplete incomplete SH3-binding domain PxRxP further upstream. It is likely that Phostensin targets PP1 to the F-actin cytoskeleton. Phostensin binds to actin and decreases the elongation and depolymerisation rates of actin filament pointed ends.
Links
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Statistics
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PSSM-Id: 520991
Aligned: 9 rows
Threshold Bit Score: 132.384
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
A2AI08        506 FQEAKLPSSAVGV----PSQYHLHPARPGH------TSELLNRGSNTFTVVPKRKPGTLQephlSQTNGQ--SQqgaEEQ 573  house mouse
XP_003794855  472 PEEAKLPCSGVGV----PLQYCPHPARPGH------LLELQHRSINTFMVVPKRKPGALQeqcfGQANRDppPQ---EEE 538 
XP_030870048  525 PQAAKLP-------------YLPHPARPLHparpgcVAELQPRGSNTFTVVPKRKPGTLQdqhfSQANREprPRe-aEEE 590 
XP_006163428  236 SQEAKLPDSGIHT----PPRYCRQPAGPGH------AAGLQQQGSNTFTVVPRRKLGVLQeqysGQANGEpqPQvteEE- 304 
3_pfamImport    1 ----KLPVTNIDD----MVNLETMKI---H------SSILQHTVGNTFTVLPKA--------------KQitSEkrsSGV 49  
Q6NYC8        438 PTAPQPPGDPLMSrlfyGVKAGPGVGAPRR-------------SGHTFTVNPRR--------------SVppATpatPTS 490  human
XP_698574    1135 SSTPSPPLFSIRS----------ASGGPSK-------------RGTTITITPRR----------SAGSSSpgSTptaTSP 1181
XP_026691740  418 KSTAPTPSNNATGll------fgKRGIPSK----------GFGGGNSFVVDPRKFKRGNPspntTIKKQNppNEstnTEA 481  vase tunicate
XP_036756658  586 PQEAKLPCSGANV----PPRYHPHPAGPGH------PSELQHRGGNTFTVVPKRKPGALQ------ASGKpgPQe-aEEE 648  Chinese pangolin

A2AI08        574 DAESLsG-------PHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSR--KKMK-----ISFNDKSLHTTFEYP 639  house mouse
XP_003794855  539 EASCL-G-------PQAAMGSTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSR--KKMK-----ISFNDKSLQTTFEYP 603 
XP_030870048  591 EASCL-------------LGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSR--KKMK-----ISFNDKSLQTTFEYP 650 
XP_006163428  305 ------G-------PCATLVTAPKKRYPTVHEIEVIGGYLALRKSCLTKASSSR--KKMK-----ISFNDKSLQTTFEYP 364 
3_pfamImport   50 QVTSVdRttkklepSYTKLGTLPKMQYPTVDDIEVVGGYLSLDKSCLSKTGFTR--KKMK-----ISFNEESLCTTFEYP 122 
Q6NYC8        491 PAT-----------VDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERhhKQLK-----ISFSETALETTYQYP 554  human
XP_698574    1182 TAPKAaPqtqtptpAPISTRETGKKRYPTAEEIQVIGGYQNLERSCLVKSRGTP--KSVK-----VCFDEVELERVCEYP 1254
XP_026691740  482 IAPESvQhnkqvceTDAPPKG---KRKLTVDQITVIGGYVKLDRPTLVST------KKTKdvtrhVKFDSEHMESTFHYP 552  vase tunicate
XP_036756658  649 EVGSLlE-------PTAPLGTALKKRYPTVHEIEVIGGYLALQKSCLTKAGSSR--KKMK-----ISFNDKRLQTTFEYP 714  Chinese pangolin

A2AI08        640 SESSLA 645  house mouse
XP_003794855  604 SESSLV 609 
XP_030870048  651 SESSLE 656 
XP_006163428  365 SESSLV 370 
3_pfamImport  123 SESSML 128 
Q6NYC8        555 SESSVL 560  human
XP_698574    1255 SEECVL 1260
XP_026691740  553 SENSLL 558  vase tunicate
XP_036756658  715 PESSLV 720  Chinese pangolin
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