Conserved Protein Domain Family
MINDY-3_4_CD

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pfam13898: MINDY-3_4_CD (This model is not part of the current CDD release)
Deubiquitinating enzyme MINDY-3/4, conserved domain
Deubiquitinating enzymes (DUBs) remove ubiquitin (Ub) from Ub-conjugated substrates to regulate the functional outcome of ubiquitination. This entry includes MINDY-3/4. They belong to the MINDY (motif interacting with Ub-containing novel DUB) family (peptidase family C121), whose members are deubiquitinating enzymes releasing Lys48-linked ubiquitin. This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4.
Statistics
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PSSM-Id: 520978
Aligned: 31 rows
Threshold Bit Score: 383.521
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016842780  55 RMLVFGSCASPPKAEWART--GLTLRAVGQNLSFGLRAPRNST----RGLITAVQAIMLKHFLFKLTKqETRCSPDVLLK 128
XP_002423646  71 RRIVFGSSTIPPKSEWLKM--GFNYHNSNKEFSYGLKIVRNTT----SGLFSVVQAYLIKYFLFNKKK-NRNVVPEQLLK 143
EDS33504      12 RQTVFGSAASPPRGEWTRT--GINYGAASGEYPYGLRTPRNAT----RGMQSVLQAFIIKYFIFDCKPrDKSVVMEELLK 85 
8_pfamImport   1 RTVVFGTAVAPPRGEWLRT--GIIMHEEEKEVPYLLKGPKNTT----RGLLTVLQAEILKYLLFEVSInLFIIVQNLLI- 73 
XP_029344052 108 RLTVFGACDTPPRGEWLRT--GFVFRDPEKELSYGLRARRNGT----RGMQTAIQGYILKHLLFTSTN-------NSCMK 174
XP_019882367  73 RTLVFGSCASPPKIEWTRT--GLTLRPYGQSLAFGLRTPRNTT----RGLVTAVQAIMLKHFLFKCNRqDLRVEPETLLK 146
XP_046453708  62 RQVVFGQCPASVRPEFFNQgpGLVFREHGHPLAYGLSITNPSTlpmmRAILMTIQAQILRTLLFDSAIlKLPKTCNPLMP 141
1_pfamImport   1 RRMLFGSTFQVFSYDWKRS--YFRFHDPHTDLAYALVTDKGGA----AAVQMAVQVNIIKYLLFVRNQ-EENVQLQSLCE 73 
XP_048589055 190 RTVLFGTCGTSFNSDWRKQ--HINFS---MNSHYGLSFYKPGP----AGVLACLQAFLIKNLLYFN---ATPAIAKSMLQ 257
XP_002107678  75 RKILFGQLMVPKEIDWCRE--SFIFHIHNYGLPFGLKIHKNGP----CGVIAVVQAFVLRHLIFDE---DDENNYKRLKA 145
XP_016842780 129 PSYEKQVVVLTASIAEIIWRCAGGFavqnasasfnsaasslnipK-AVVVLPQET-PYLQ-HSvQYFQDGLTETLHLFEF 205
XP_002423646 144 PDKVEQVEALWTSLSDLLWIVGEKK-------------------N-CKICLPRSP-PCLQ-SSsDYFSDGLTERLHIFDF 201
EDS33504      86 PTEAEQAQALYLAISDILWNIGEKT-------------------K-ALIVLPGEN-SLIP-HShAYFQDNVTEKLFFFEF 143
8_pfamImport  74 ------FCCLFELKSNVMVTANAKImfclfssralskttntqlkK-VILCLPQEN-VYLH-QSlDYFQDGITERIHMFDV 144
XP_029344052 175 PSKQQQLDALCKSITEILWKIGDNE-------------------K-VIVCLPQEK-SYVA-HSlNYFQDNVTEKLHLFEL 232
XP_019882367 147 PSYDRQIEVLTSAISEIIWRCAGGFsgsmctn-----vvsntvpK-AVVALPQDT-PYLQ-HSvQYFQDGLTETLHLFEF 218
XP_046453708 142 TTVTIQQEALAYAIANIIWKSGNEQ-------------------S-ATLCLPQPNvVHIV-GSpQFNEDGLTEKLQLCQM 200
1_pfamImport  74 ISQKDQEKALSAALADILWTAGEYQ-------------------K-ATVCLVTSDtYFTP-SK-DFELDHFTESVQLFDF 131
XP_048589055 258 PMSSDRQRALVAALSQMMWQAGERK-------------------H-AVVTLPCGEfQWLS-YE-GYKLDHLTENLMLFTF 315
XP_002107678 146 VNERERQNALALALADILWIAGEES-------------------KtAIVLLPPDDdRSKPiGAsQVRLNDMTEDGILYQF 206
XP_016842780 206 TTLDDLEIFIKRYLYLFQDEGGPGAKILLYSAILSRGLSKVRNDMEDPRA-----------SILSgcpEEGPLS--LVVL 272
XP_002423646 202 TTLEDLRAFLKRYIYVFLEESGPGALLILYSAILTRGISQTSEDMKTVGS-----------CFLSg-eDEGLNC--IITL 267
EDS33504     144 TKLDEMQIFMKRYLPYFTENPGPGALLLLYSAVVTRGMENLRNDLDAPKG-----------AHLMgpyEEGSLN--IVTL 210
8_pfamImport 145 ESYDDLEIMIKRYSYLFLDDPGPGAMLLLYSCVASRGPDQVVKDMDGVKA-----------QLIgp-eEEGSIC--LVTL 210
XP_029344052 233 TNIQDLEIFLKRYLHLFQDDPGPGSLLLLYSAVLTRGLSKIVSDLMDEKV-----------YLISs-aEEGSIC--IVTL 298
XP_019882367 219 NSLEDLEIFIKRYLYLFHDEGGPGAKLLLYSAVLSRGLSKVQNDLEDPKA-----------SILGgcsEEGPIS--IVVL 285
XP_046453708 201 NRIEELHHTIRRNIHVFQEDPGPAVMLILYSAILTRGINQVTEDMGKPSGgdgiltpmkslMSINgsiMFGPIS-----L 275
1_pfamImport 132 FEKDTTQQFLYDHIHCMKWEGSHGVILFLYSLLFSRTFERLQKDLDFTTT-----------HLLQcrlGNFICRqaLLNI 200
XP_048589055 316 SDFDELQRFIKRQVTFFESTSGDGCILLLYSIILSRTTKRVTEDLSEPNS-----------ILLD---SNNGCSqaMMNL 381
XP_002107678 207 NAFNDLRDFIKKKLPIFQHEFGYGVAFFLYSAILSRGIENIRNDMDDPEK-----------ILLT---ENERCSqeLINL 272
XP_016842780 273 AITGRASPHLHNGVIHVG--DENTYAIPQWGVLVRSEIGFLvhegDTT-----ASKQ----PGSRLKTPSLPIWVTLCL- 340
XP_002423646 268 LLTGRATPFLHNGVVYVG--DEDHYAMAQWGIMSRSDIGFLlyndRDDckilnESKQ----PGSRLKTPNFPIWVTFNS- 340
EDS33504     211 MLTGRATPYLHNGVVYVG--DEDHYALPQFGILGRGSIGLLvwegENEam-rsASRQ----PGSRLKTPATPVWVSCCC- 282
8_pfamImport 211 LITGRATPYLHNGVVYVG--DEDHYATAQFGILARSEIGLLvqmdTID-----ADNEcn-iPGSRLKTPSLPVWVVSTC- 281
XP_029344052 299 MLTGRATPNLHNGIVNIG--DEQHYAIPHYGILARSEVGLLvhyeESS-----TPVQvtqiPGSRLKTPSYPIWITCAK- 370
XP_019882367 286 ILTGRVSPHLHNGVVHVG--DENTYAVPQWGVLTRSEVGFLihegDVS-------KQ----PGSRLKTPSLPIWVTLCL- 351
XP_046453708 276 FLLGRASPYLHNGVQYQD--DGDS-RTEETGVLIRSPIGLLlwmgN-------EAKTaaynVGSRFKTPTVPIWVVVAS- 344
1_pfamImport 201 ILTGRASPHVFNGSQRLD--SEGNMQKVLHGVSSRSDVGYLhwskEEVehy--rlLQ----VGSMLKTPKLPIWLCNIN- 271
XP_048589055 382 LLTGRATKNVFNGDVEYn-kRGTILAYPQKGIKERSEIGFL----TLWehidsKDVE----VGSKLKTPKFPVWVVDSTg 452
XP_002107678 273 LLVGKAVSYVFNGILDYDykLRKPLQQPLFGIDKRGVVGLL----TLMehvaeGNYT----VGSKLKTPKYPIWVVNIE- 343
XP_016842780 341 GHHGVLFNTNRELLRNYHAERRFDLQYYTCGGSHAT-----LTVDTRARENASGIegSaa-rETMDIAATP---LEKLIH 411
XP_002423646 341 GHYGVLFNTNSELLRNYHAERRFELYYYTVEGSCLT-----MSVDTRYKKFNKEEenNdr-eKTEDFLSIPlssIEKLIH 414
EDS33504     283 GHYGVLFNSNRELLRNYHAEKRFELHYYTCAGCYIS-----MTVDNRQQEDGADDgdGdgerKQSDMVSTP---LERLIH 354
8_pfamImport 282 GHYGVMYNTNRELLHNYHAERRFDLTYLTCGGNQCQ-----LTVDTRQSSGTYMI-------HSEETTVTPianIEKLIQ 349
XP_029344052 371 GHYGILFNTNRELLRNHLAERRFPLTHYSCSGSENH-----ATVDTRSHQGEQTRimKa--tDDINNTTSLlllVECLIH 443
XP_019882367 352 GHHGVLFNTNRELLRNYHAERRFEVQYFTCGGSHAT-----LTVDTRANQ-TSGLsdAat-mEAADIAATP---LEKLIR 421
XP_046453708 345 ENSGVLFGEDKGLLRDHQAENRFQLHYHTSTFHQQNpv--iLKINNRVRDD-----------SSADAPIPP---LERILR 408
1_pfamImport 272 GSYSVLFSTNRLLLSDWKMEHLFDLYFYNGHPSKKRtv--hLTIVSKKTLNAYLL-----------RKFPS---VEMAIR 335
XP_048589055 453 GRYGVVFCLNKDLVNDWRLERRFELYYYNGTTRHSGavgdvITVDTRDI---VDE-------NEVTEDTHP---VEHCLR 519
XP_002107678 344 LSFAVIFSCKRDLLNDWKAERQFHLWYYTGLVSQTElq--rIHIDTLQT---YMP-------KNKDNVEPL---INHCIR 408
XP_016842780 412 SKWQDAQVQWNG 423
XP_002423646 415 TKWEDAAIVFKG 426
EDS33504     355 TKWMEAKLTYHG 366
8_pfamImport 350 TKWPDAQISWHG 361
XP_029344052 444 TKWEGASVQWTG 455
XP_019882367 422 SKWQDALIQWNG 433
XP_046453708 409 TKWGDARLDWGN 420
1_pfamImport 336 TKWEGAAINWNG 347
XP_048589055 520 TKWPGAVIEWSS 531
XP_002107678 409 TKWSGVKISSHS 420
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