Conserved Protein Domain Family
RRM_5
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pfam13893: RRM_5 
RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
The RRM motif is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins.
Links
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Statistics
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PSSM-Id: 493786
Aligned: 6 rows
Threshold Bit Score: 186.54
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002431034   6 NFRHNPGFQGSPALLSTsg---alGVTTGPVMMVYGLDTKKLNCDKLFNLFCLYGNIARIKFLKTKEGAAMIQMGDGSAV 82 
NP_725914    148 PAGVVPGRNAPVAFTPQ-------GQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAV 220
XP_040035805 302 SQRYGPSYGPPPPEYGP--------HADSPVLMVYGLEPSKVNADKVFNIFCLYGNVERIKFMKSKPGAAMVEMGDCYSV 373
3_pfamImport   1 DPLFIPSATLEVAATGWiaipglaGV-GNSVFLVSNFNLDRVTLQSLFILFSVYDNVQRVKILFNKKEYTLVQMANASQA 79 
NP_001391369 234 PGALGPLTLTSSAVSGRmaipgasGMPGNSVLLVTNLNPDFITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADASQA 313 house mouse
KAF8386769   332 GGNAPTDYYGYGADTGMv-----qPYKESGVVMVYGLEPGRFNCDMLFNMLCQYGNVNKVLFMRSKPDTAMVEMGSGREV 406 Pristionchus pa...

XP_002431034  83 ERCVQHLNNAPMfDSknRLQLGFSKQPFLSDvTNPFVLPDGSPSFKDFIRN 133
NP_725914    221 ERCVQHLNNIPV-GTggKIQIAFSKQNFLSEvINPFLLPDHSPSFKEYTGS 270
XP_040035805 374 DRAITHLNNNFLfGQ--KLNVCVSKQQAIVP-GQCYQLEDNSSSFKDFHGS 421
3_pfamImport  80 QLDRSHMNGHKLhGK--PIGIILSKHQN----ALPHEGQKDEGLTKDYGNS 124
NP_001391369 314 QLAMNHLSGQRLyGK--VLRATLSKHQAV---QLPREGQEDQGLTKDFSNS 359 house mouse
KAF8386769   407 QTAIDHLYGTEIfGS--RLELKPSKQGEVAY-KEPFELADGSPSFRDYSSS 454 Pristionchus pacificus
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