Conserved Protein Domain Family
Rab3-GTPase_cat

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pfam13890: Rab3-GTPase_cat (This model is not part of the current CDD release)
Rab3 GTPase-activating protein catalytic subunit
This family is the probable catalytic subunit of the GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). It is likely to convert active Rab3-GTP to the inactive form Rab3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. This complex interacts with DMXL2.
Statistics
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PSSM-Id: 520972
Aligned: 39 rows
Threshold Bit Score: 156.261
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002292469 1831 HNHNRVGARCP---VpDVLPLIETG-DQLYAPYLQRTMPVTDEEEEKQKKLLgVSRKDEDekRVSIQSriaisQRLQKPK 1906
XP_002183212  911 QVRERKGARCP---M-KNINLLETG-DQLYAPYLQRPYPLTDDVITQRRMML-LKQKSSGkaSSTVLRrmevaHLLQKPK 984 
EFX66131      560 AWNQPQGRKER-----TKMKLLRSG-ETLYIPVTQALLPMTEDMIEEQSEMM-EQLGDNA--EGSELR-----ARILSAS 625 
EFN83718      119 LWNKPAGRLAK---H-SSLRLIQSG-DPLYLPVTQDPVPKTEDQLEEDAQVM-MQLGTDK--YASEMR-----ARMMSAS 185 
EFA03502       78 LWNQPVGRLGK---F-NNLKLLKTG-DPLYIPVTQEPVPKSEDQLEEDTDVL-LKLGSDA--QGSELR-----AKMMSAS 144 
EDX03351       60 LSLKPEGRLRR---L-NNERLLDEPdEYLYIPDTQEPVPKTEDQLQDDAEVM-LKLG-----PGSGLT-----TQMMCTS 124 
EDS32721       60 SLSQPVGRLSR---L-GKMLLVDSD-EPLYIPITQEPVPKTEDQLEDDAEVM-LKLG-----PGSELC-----TQMMSAS 123 
XP_001899546  606 DSSGAEGRLKP---F-GTLRLIHYPdRLMYEPVTQTRVPVTEDMLEKHAEYL-ASLKDPE------ER-----VKAQLEP 669 
XP_001466186  810 EENVAATSLTA---S-PVRYLITNG-EVLCVPPPLPQPPTTADEVVKRAVEL-NSLDATAveSASV-------EWLQTDA 876 
Q4DXS5        602 EASAADGECSAdgfLiSGKCLITNG-EPLVEPKALPTPPCTSDVMMMKAQEL-QNLGTES--AGRHTR-----AWIQSEG 672  Trypanosoma c...
XP_002292469 1907 LLSDMSSFK---AANQGAV--FEDFVRWYgNPQNPLSEEVNGetarraaqyrsklppeeakvlalEEASEAIAilmSLR- 1980
XP_002183212  985 LLSDMQAFK---AANPNAI--FQDFVNWYgNPRDPLEEyeeslslalrp------gtsdtietklDKAKEGIYvlsMTR- 1052
EFX66131      626 LLSDMESFK---AANPGAQ--IEDFVRWH-SPRDWIEEEVVTsdgc----------------kieGRLSGRMQ---TPG- 679 
EFN83718      186 LLSDMESFK---AANPGAV--LEDFIRWY-SPRDWIDDEGLDewg-----------------qgkGHLSLRMM---IPD- 238 
EFA03502      145 LLSDMESFK---AANPGSV--LEDFIRWY-SPRDWIESEELDewg-----------------qkkGELSSRMM---IED- 197 
EDX03351      125 LLSDMEAFK---AANPRGI--MEDFIRWY-SPKDW--EEVTDelg-----------------qvkHQLSIRMT---TEG- 175 
EDS32721      124 LLSDMESFK---AANPAGK--LEDFIRWY-SPRDWIEEDADErdpf----------------grkGHLSSRML---IPG- 177 
XP_001899546  670 LFSDMEAFK---AANPGCC--FEDFVRWH-SPRDFIVNDENTg---------------------eGCLSSRMT---GEG- 718 
XP_001466186  877 LYNDMCFFLyvnKAHEGRIvrFPDFVQWH-SPRDFVASAGAEsttspsver------psrslsdnDYLSERMQ---RQQk 946 
Q4DXS5        673 LFNDMCLFLyfnRAQEGRVvrFPDFVQWH-SPRDFIPPLCDSkekk---------------ddddAYLSERMR---RHSn 733  Trypanosoma c...
XP_002292469 1981 -----------AFWEDSWDEAEP-CPAFEQEPLFDPYSTVEMVFHSFE 2016
XP_002183212 1053 -----------DFWTGTWKEAKP-LSASFQEPLFDATMTVEMMLDFLE 1088
EFX66131      680 -----------NLWQEMWRTAKP-VVAWRQKRLFDDTKEAEKILHTFS 715 
EFN83718      239 -----------NPWSTTWASAQP-VPAHRQKRLFDDTREAEKVLHYLC 274 
EFA03502      198 -----------NFWVQTWDSAKP-VPAHRQKRLFDDTREAEKVLHFLD 233 
EDX03351      176 -----------NTWQKVWEQAQA-VPVSRQKRLFDDTNEALKVLHYLE 211 
EDS32721      178 -----------NTWQTVWENARA-VPARRQKRLFDDAKEAEKVLHFLE 213 
XP_001899546  719 -----------NTWQQTWNRAQL-KPAYRQKLLFDDLKAANKIISDFE 754 
XP_001466186  947 ecgasggkgsaHVWWSLWRRATPrSRDDIVHGLFQPLEQATKILAWLA 994 
Q4DXS5        734 aen-----glvNIWWPLWERATPrSPEEIIAQSFVPHEQARLIIRWME 776  Trypanosoma cruzi
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