8J07,8J07,8TEK


Conserved Protein Domain Family
CCDC113_CCDC96_CC
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pfam13870: CCDC113_CCDC96_CC (This model is not part of the current CDD release)
CCDC113/CCDC96, coiled-coil
This entry represents the coiled-coil region of Coiled-coil domain-containing protein 113 (CCDC113, also known as cilia- and flagella-associated protein 263, CFAP263) and coiled-coil domain-containing protein 96 (CCDC96, also known as cilia- and flagella-associated protein 184, CFAP184). These proteins form a complex and regulate ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC.
Links
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Statistics
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PSSM-Id: 520954
Aligned: 47 rows
Threshold Bit Score: 96.1381
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8J07_i1      365 EDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGLLLIDFEQLKIENQTFNEKIEERNEELLKLRSKVTNSVQVIT 444 human
XP_001628027 182 LRARDTLIEKLRLKNSTLKVQKRKLHMQLKQKEEMGEVLHEVDFNQLKIENQQYLEKIDEKNQDLLRLKLMSGNVQQILN 261
Q5XJN6       164 IKAKDILIEKLHRKNSALLTHKKKQQAQLRQQEEMAEGVTVLDFELLKFENIRFRKQLDEQNLKQVNLKLLAVKTLQTLN 243 zebrafish
XP_017948854 265 MRARDSLVDKLRLKNAALKVQKKKMKMQVKQKEEMGEVLHEVDFQQLKIENAQFLERIDERNQDLLQLKLTAGDTLLVLN 344
Q8C5T8       179 NRRRDNIKDKLCLKNVSLKVQRKKMLSQLRQKEEVGEALHDVDFQQLKIENAQFLETIEARNKELIQLKLASGNTLQVLN 258 house mouse
Q9H0I3       179 NRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLN 258 human
Q57UP0       244 HGAQGKYLDKLNAQCAAAERSILQHQRNLKQRRAAGEAFHAIDFEQLRIENQKFVERIERKNLELVELKGTSTRTVQTLN 323 Trypanosoma brucei
Q4DUJ8       240 YSMQAKYLDKLNVQCAAAERNITQTQQQLRQRHAAGEAFRAIDFEQLRIENQQFNERIERKNLELVELKGTSTRTVQTLN 319 Trypanosoma cruzi
8J07_i2      179 nRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLN 258 human
8TEK_T       166 ERQKDALIAKYSSKRTNLERQILKTNNQIQKKEEMGDDLKFIDFYQLQIENKKYVKEIDDKNKKLLALKISTNRISQTLK 245 Tetrahymena the...

8J07_i1      445 HVKEKLHFMDMENACKKTQLAEIEAQAALGRDILTKTKQAREGLRTDNIRLNQKCGLL------GKDSLLRdLEEKVDKT 518 human
XP_001628027 262 TYKKKLHTLTMESERLRTEIGQRNELLFKIDAETNLVQTDREKAELLNERLKQQLADY------KVPDVMD-YVGERAKL 334
Q5XJN6       244 SNKEKLHILTNESEMLSSDTALRTKLLVKIEEETEQAEEERHKAEALNRKLRDQLADF------HVPHVLQ-YIKLKESH 316 zebrafish
XP_017948854 345 LFKKKLNTAMAESTHLDKEIHMRKEMLQRIELEAQLVEQDREKAERVNKKLRKQLHDY------RVPDVLE-YIQEKTDQ 417
Q8C5T8       259 TYKNKLHRAMEIYVNLDKEILLRNELLGKIEKETIQAEEDRAKAHILNDKLRKQLAEF------RAPQVMM-YVKEKILN 331 house mouse
Q9H0I3       259 AYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEF------RAPQVMT-YVREKILN 331 human
Q57UP0       324 NLMDTLNGLTSEQSRLRKDYKNRCEYLARLKREMVSVAQEAKVAEQKNTAIKLRHEAV------RVPKIEN-YMAQKAEE 396 Trypanosoma brucei
Q4DUJ8       320 TLMDALNGLTAEQNRLRKDLKNRCEYLARLQREMVSVTSEADAAERKNATIKSQHEAV------RVPKIEH-YLAQKAEE 392 Trypanosoma cruzi
8J07_i2      259 AYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEF------RAPQVMT-YVREKILN 331 human
8TEK_T       246 DEKQNLKQELDKGKEYASQMSERKKKISKIDAQIKSVKKVTSKLEKDRKIYDKQKEIFvqdnqdDVPQIMK-YVQYKSKE 324 Tetrahymena the...

8J07_i1      519 ELLHRRLESLKRHHASLTLSCRG 541 human
XP_001628027 335 YELNKVVRMWERKVEIAEMALKT 357
Q5XJN6       317 GQLQKSVREWERKVEIAEMALKT 339 zebrafish
XP_017948854 418 EDLEKSIRIWERKVEIAEFSCTS 440
Q8C5T8       332 GELEKTIKMWERKVEIAEMSLKG 354 house mouse
Q9H0I3       332 ADLEKSIRMWERKVEIAEMSLKG 354 human
Q57UP0       397 YELRKAQRNWQRKVEIAEGQLGL 419 Trypanosoma brucei
Q4DUJ8       393 YELQKAERHWNRKVEIAGGQMRL 415 Trypanosoma cruzi
8J07_i2      332 ADLEKSIRMWERKVEIAEMSLKG 354 human
8TEK_T       325 QQLLYAIQNLERKIEIAELAYKK 347 Tetrahymena thermophila
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