8J07,8TO0,6U42,8G2Z,8SNB,8G2Z


Conserved Protein Domain Family
TPH

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pfam13868: TPH (This model is not part of the current CDD release)
Trichohyalin-plectin-homology domain
This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Statistics
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PSSM-Id: 520952
Aligned: 120 rows
Threshold Bit Score: 86.5163
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8J07_3W      114 VRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAE-IAKTMMEEHKriIKEENAAEDKRNKAKAQYYLDLE 192 human
XP_001566941  35 LVRDYPEVRSLEAQLKYAYLRKSRAEQVTDRTAAKALEAEEQRRyMEHLAEKDRL--AKVEEEKKRQEDMERFRRHQAAQ 112
Q587B8        70 FVRDLPELRNLEAQLKHARMKVDRSDQVDECCKRREERLQEEREyNAYLAEKEAK--EKAEEEEKRRKAIQAFNEHQAAQ 147 Trypanosoma brucei
A0BH54        41 ICAESEEIKLLKQKVQTAYVTKERTQQLAEQQLRRIQELKQESE-IEAAILEKLKreQEEERSKEKFRLQQRLEGKYTLQ 119 Paramecium tetr...
XP_001017577  65 IYEESEELKLLKEKIRMAQVNKERTRQIAENQLRKFQTKKVEAE-LEENILRKCEeeKRYEAEKERILNEQRMQGRFVLQ 143
XP_002683398  43 VRLESEEIRILEMKLRTAYVNVERDRQLKHKEDIAQKHREFEKQ-QESDMERERQkiIQQLNDIEEQRKAQNLLAKQKLQ 121
XP_002896208  96 ICEASEELRELESFLRTAYMNKERATQQLERETLTALDRQREAA-IDHQMEYDRQraLVDMQNHELRKRVEAEQGKQVLQ 174
XP_002286669  56 ICETSEELKELERQLKIAYVNKERATQHQEALLLRKLEHDREQA-IEEKMEHDRQleIRLLEERENKRRQSLIVQKKVLQ 134
8G2Z_0H       65 IYEESEELKLLKEKIRMAQVNKERTRQIAENQLRKFQTKKVEAE-LEENILRKCEeeKRYEAEKERILNEQRMQGRFVLQ 143 Tetrahymena the...
XP_018635875 105 VCDESEELRHLKEKLQMAKVNRERAAQVIEHQIRAVEEEEIQAA-IDAQVEAGRLhlLEEEKRLQLQHLEKERAAKDMQR 183 Toxoplasma gond...
8J07_3W      193 KQL-EEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKII 271 human
XP_001566941 113 LEIiRQHRLAATEEAKQREQERIAVDAVVARVQEQDFLETLARRDRQRQLMEEQDEFCRLRAAMKKAEQDREAKEEAAIR 192
Q587B8       148 LKLiEERRAQAERDAEQSRQERFAVDAVAARLQEKEFLEALERREKQRQLQAEQDEFYRLRKEIKENERLRQQREDEAIE 227 Trypanosoma brucei
A0BH54       120 KQM-KEHEQLRDEAKEQYIYEKDQVNRVIQQLISEDRKFIEDQAKKKKIAFSDMQNALREKAELIYRMKQREREENQKYL 198 Paramecium tetr...
XP_001017577 144 QQM-LEKRQAAEEAHQQYLLEKDQVNAIVQNIINEDKMAYESDKLKKKRNYQDMVEALQEKAERKAQEKINEQLENAKYK 222
XP_002683398 122 EQM-EEKEREKEMAYLEYLRDKEMIDAITKRVMEEEDREMKERFEKKKMVQTFIDEFKEARQSSKDREKRQKDLEEQSII 200
XP_002896208 175 SQM-LQRQELRREAQLDADFERLKIEQLMEQVEQEDAAELARREKARDQTREMIEQTHRERERAKQEQVEAVRREDEAIA 253
XP_002286669 135 QQM-MEREEQHTALREEASRDKQMIDDIIARINREDELEHQERMRKVEETRAIVADFQQERILQKEALERERREQEAEIK 213
8G2Z_0H      144 QQM-LEKRQAAEEAHQQYLLEKDQVNAIVQNIINEDKMAYESDKLKKKRNYQDMVEALQEKAERKAQEKINEQLENAKYK 222 Tetrahymena the...
XP_018635875 184 QQIgERRESRKREAAEEYNRDKAQVQDLIRQLLEQEDQDNRRNAAKRAAERQQIQESLRQKELWRQQQIALSEHEDAKIR 263 Toxoplasma gond...
8J07_3W      272 EFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMK 351 human
XP_001566941 193 AYLDEQARRREMDAKVARERDAVKARVLEEQGRRIVEEEAKKRELEMLLQEYYEEERLTKEQMLIAAEKASRERMAAAVT 272
Q587B8       228 AYLAEKGRRRETDEKLLREKEAVKARILEEQSKKIMEERLKREELESLLSDYYEAERISRERQALADAKERSEKLADAVK 307 Trypanosoma brucei
A0BH54       199 DFMKEKDRQAHEIKVKKQEENAAKDKIFQKLKEEEERRRQEAELLTELRFQLYQEQYDAQQRQKDIDEANKREFQKREMQ 278 Paramecium tetr...
XP_001017577 223 KFFEQKEQMQQEIKKKREELEAQKAIIFERLKAEEERRRKEKELIEDLRMELYKEEFEAQERRKDREEREKRERTKQELQ 302
XP_002683398 201 QYQKYLQMREEEEKLKKATVQERRDKLLEIQSKELENQRRLMEETEELLNELYAEEKKERERLKEIEESERKQQQKSDML 280
XP_002896208 254 DYQRQVQAREAGIKAASDVKKAQEDAMFRAVEAEIQAKMREEEEIERLRDELWEEELLQKKRAQEEERIAAKQQAKEDMM 333
XP_002286669 214 VYDEMMTQRTLKEEAERKRTEEEKKRRWKKVVEETRNQTQSKEEFDTLRAMLWEEELEAKRKKEEEDATVKYMQQKEIMM 293
8G2Z_0H      223 KFFEQKEQMQQEIKKKREELEAQKAIIFERLKAEEERRRKEKELIEDLRMELYKEEFEAQERRKDREEREKRERTKQELQ 302 Tetrahymena the...
XP_018635875 264 EYAALQAARNEKLDQEREEREAEKRRVLLELSRQKLERDAREKEHQQLLDDLHLDEKEELERQKAEAESRRKQEDRKALL 343 Toxoplasma gond...
8J07_3W      352 QDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQ 431 human
XP_001566941 273 RENQQLIDQRRLAKEAQLADELRFRQLAMEQLASEAKMQQLNRQKQAQLKRQHIAEVQQRLEERRLLKEQEKELERKVEE 352
Q587B8       308 QENWNLIQDRIKARDLERQEEAMMRQKAVEDLAQQAKAKRLERERQIEIKKQKILETERRLEKFQELKREEQRLAAEVEE 387 Trypanosoma brucei
A0BH54       279 QAEQEARLRKQRQKEEEQQMERDFRDQMMRKFAEDDKLEQLGQQKRRMKEVEHKREVERLWQQKLEMYQMEKQKELEQLE 358 Paramecium tetr...
XP_001017577 303 EAERQHKYDKERQLAEEKRMEQQFREKMMEKYAQDEKLEQLSAQRRRMKEIDHKKEVERLWQEKLEMYREERERELEEAR 382
XP_002683398 281 RVNHEQLMLKQNRIQEEKLHEEAFRQLLIQKFEEDEKVAQMSAQKKRMKMAEFRRDVEDYLNQRTQMKEMERQQLILEQN 360
XP_002896208 334 RSNDMQMQLKQELLARQRADEEAFNEMLRERFRSEERREMELAAFRRKQREQFVEEIARHRALKQEMVYAELQRERRERE 413
XP_002286669 294 RENKAQIAAKREMLEQMEREERELVDRMLKKFAEDADDERRKEENRRAFKERFMAEANQQRLERRAMVHGEKQRVLKERD 373
8G2Z_0H      303 EAERQHKYDKERQLAEEKRMEQQFREKMMEKYAQDEKLEQLSAQRRRMKEIDHKKEVERLWQEKLEMYREERERELEEAR 382 Tetrahymena the...
XP_018635875 344 RAFDEQMAEKERRRQEALENEQVYRQKLLAQFAEQDRIEQMNEQKKRLRIQEHMRQVERLIIQRRQLFEAEREAEKQTWE 423 Toxoplasma gond...
8J07_3W      432 LQQRRQGFINAIIEEERLKLLKEHATNLLGYLPK 465 human
XP_001566941 353 QDRKREEQIQEYIRRARAQLLAEHLPKLGSYAPV 386
Q587B8       388 RERKRAEELQEYIRRARAQLLEEYVPTLGQHVPA 421 Trypanosoma brucei
A0BH54       359 RQRREEAYKQLVVEEEKNRILQEHLQQVGEFIPK 392 Paramecium tetraurelia
XP_001017577 383 KNEELKSYKDELIRLEKERLLREYLDELAGFMPK 416
XP_002683398 361 KEIQRAEEKQRMVEQEKAKLIKEHAAKILKYLPK 394
XP_002896208 414 RQEQDENYRRQVVEAAKQRLLREHAEVLQGYLPR 447
XP_002286669 374 VLKEQEEYKQRVINEARRKLLEQHAAQLQGFLPT 407
8G2Z_0H      383 KNEELKSYKDELIRLEKERLLREYLDELAGFMPK 416 Tetrahymena thermophila CU428
XP_018635875 424 RLAAVEEEKQTVVEQERLRLLREHA-ELAKFLPK 456 Toxoplasma gondii ME49
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