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C-terminal duplication domain of Friend of PRMT1 Fop, or Friend of Prmt1, proteins are conserved from fungi and plants to vertebrates. There is little that is actually conserved except for this C-terminal LDXXLDAYM region where X is any amino acid). The Fop proteins themselves are nuclear proteins localised to regions with low levels of DAPI, with a punctate/speckle-like distribution. Fop is a chromatin-associated protein and it co-localises with facultative heterochromatin. It is is critical for oestrogen-dependent gene activation. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",