7C4H


Conserved Protein Domain Family
BCCIP
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pfam13862: BCCIP (This model is not part of the current CDD release)
BCCIP
This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and BCP1. In fungi, BCP1 is involved in nuclear export, actin cytoskeleton organisation and vesicular transport. Its homologue in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2.
Links
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Statistics
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PSSM-Id: 520948
Aligned: 164 rows
Threshold Bit Score: 103.457
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7C4H_A        48 IVNIDFDFFGGNPevDFHALKNLLRQLFGpQESTRIQLSSLADLILGSPt--TTIKTd---------gKE--------SD 108 Saccharomyces c...
Q384C3        86 VVDVDFGVFDIREq-DVNAIMHLMDQFCP-DRMNEVDREDLGTAFLKSPf-tCIVKIsndyvcnddiaSSggeeeggvEE 162 Trypanosoma brucei
Q4CW74        78 LINVEFGVFEMRR--DVNAVMHLIDQLCP-DKMNEVDRDELGAALHESPf-tCVVKIgdded-ddeeeEE--------EE 144 Trypanosoma cruzi
EGT55652      85 VMDFDFEAFEPSEd-DRDGIINMLTQTFLrTDI---DMKGMAEEIIAKNphgIVLKQaed------ddET--------EE 146
Q61GH1        69 IMDFDFEGSAPCDd-DRDGIVNMLTQTFLrTDI---DMKAMAESIISKAphgLVLTQayd------deQT--------EE 130 Caenorhabditis ...
4_pfamImport   1 IIDFDFEAYPPSEd-DRDGIMNMLTQTFLrTDI---DLKAMAEGIIENAphgIVLTQaye------eeET--------EE 62 
Q23402        67 IMDFDFEAYPPSEd-DRDGIVNMLTQTFLrTDI---DLKAMSEGIIAKAphgVVLTQayd------deET--------EE 128 Caenorhabditis ...
XP_002902554  75 NVNVDFLFSDPREa-HFHSVKQFLLAYLPpTQP--FDVSGLANAIVGQVtagTMVCV-----------EG--------ED 132
XP_001026398 131 VLNVDFEFKDANEt-MFHSVKGLIN---GyLDGSDYNSSDLADIIVKQFtlgTFIVId---------eEE--------DE 189
A0C0D4        39 EINLDFVFLDPNQk-QFHSIKSFIN---GyLEGISFKSSELANIICDQVelgTMVGQ-----------ED--------ED 95  Paramecium tetr...

7C4H_A       109 P----------------YCFLSFVDF--KANH----LSDYVKYLQKVd---------MRLST-FFKTmiD---SGnknCA 153 Saccharomyces c...
Q384C3       163 Dv---------------YGVASVLDLahDSRL-----GSLLNLLKTDvwrt---vspGVLPTeLLTT--LeekTGrakCV 217 Trypanosoma brucei
Q4CW74       145 Ei---------------YGMASVLDAvhDTRL-----ESLLRTLRENvwrt---vapGILPTeMLKS--TddaTGrakCV 199 Trypanosoma cruzi
EGT55652     147 Dfm-------------iYQLCTTLPLneKKDDapkfIKDIFTYLLNRakksasseiyKKIQE-IQ----E---AGdgfTG 205
Q61GH1       131 Dfm-------------vYGLCTTLALneNKENspkfIKDIFTYLLNRakkgapteiyKKIEE-IQ----E---AGdgkTG 189 Caenorhabditis ...
4_pfamImport  63 Dym-------------vYGLCTTLPLndKKDDapkfIKDIFAYLLNRakkgapsefyKKIDE-IQ----E---SNdgnTA 121
Q23402       129 Dym-------------aYGLCTTVPLndNKDDapkfIKDLFTYVLNRakkgapteiyKKIEE-IQ----V---SGdgkSA 187 Caenorhabditis ...
XP_002902554 133 Dv---------------YGFITALNLksFVNEt--sIQQILQYVTKKcps----telSKLQQ-IL---------NtknVG 181
XP_001026398 190 NqkkirekakleretnvIGFSTFISAkqHENQs--vVKEIIKFVNQKsekfnneadhKKLQN-IL---------AknkVG 257
A0C0D4        96 Nv---------------FGFTTILNIgeIKSNa---IGEILHYVDTKsqqy--nkqhQQLQH-IF--------QTpkkIG 146 Paramecium tetr...

7C4H_A       154 LVLSERLINMPPEVVPPLYKITLEDVat----alGDDk-------HYDF-----------YIIVTRKY-EVNFDTDDD-- 208 Saccharomyces c...
Q384C3       218 FLVGEYIRNVPLELTSHILTDLAKRFeetfgrrvEENlkskqgkdVIHAtfp------ciFAVLSKIQrATDSPSADTga 291 Trypanosoma brucei
Q4CW74       200 LLVGEYVRNVPLELTSQIIHDMMERVet-----afNAkssmsnkaGDDApstvqaifpcmFAMLSKIQrAVDAPLKTPtp 274 Trypanosoma cruzi
EGT55652     206 LFVSERLLDFPSDVVPQIFDSIRTDLag----------------fdKKYk---------nIIYIQKLRiMENEGANQSan 260
Q61GH1       190 LFVNERLLNFPTIVVPQLFESIKTDVdk----------------feTKYk---------tIVYIQKLRiAE--GEESNag 242 Caenorhabditis ...
4_pfamImport 122 LFINERLLNFPSIVVPQVFGSVHADVtgf--------------dkAKQYk---------sVIYIQKLRiAE--GSEGGga 176
Q23402       188 LFVNERLLNFPTIVVPQIFGSIREDLsg----------------feTKYk---------tIIYIQKLRiVETDGSEAKvg 242 Caenorhabditis ...
XP_002902554 182 LVLNERMVNLPYQLVPALHSALHEDIew-----aiENedteelrnSFKMd---------yFLILATCTeEKSG------- 240
XP_001026398 258 LLINERIINVAPQAVPVLHTQLQEDYkw------fkQnhqkefkeNFDFe---------yLLCITRCAkEVKGTQ----- 317
A0C0D4       147 LFINERILNLAPQLVPILHNQLKEDInwlqke--------dpsnpLTNLd---------yLLVITKCFkDN--------- 200 Paramecium tetr...

7C4H_A       209 --------T-DSGKRNKNKDERSKKr------------vKADEVDYFHEEDRFF 241 Saccharomyces cerevisiae S288C
Q384C3       292 -------eA-SAADRKEGRDKSLPQkrkkrtvtqqheelDMKRYVFWREEDSVL 337 Trypanosoma brucei
Q4CW74       275 m----narQdPPPKKRRGQNAAQPDe------------fDLCRYLFWREEDSII 312 Trypanosoma cruzi
EGT55652     261 ksgsssssSaPPKKKGKMGKAEKKRaaa--------aalANAEIEFDNSEDRVL 306
Q61GH1       243 s----sssEaPPKKKGKMGKAEKKRaaa--------aalANAEIEFDNPEDRIL 284 Caenorhabditis briggsae
4_pfamImport 177 s----ssaSsAAKKKGKMGKAEKKRaaa--------aalANADIEFDNPEDRVL 218
Q23402       243 ass-ngssGvAGKKKGKMGKAEKKRaaa--------aalANAEIEFDNPEDRVL 287 Caenorhabditis elegans
XP_002902554 241 -------------SSGSKKGKKSKTa------------yEQTAKFFHNFEDEFL 269
XP_001026398 318 -------------DPQQGQKKLKKE--------------ELDEYLYPKFEDFLL 344
A0C0D4       201 -------------DQQKQTQKKSTS--------------DLNDLIFQKFEDYVF 227 Paramecium tetraurelia
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