5GV2,5GV2,1ZHV


Conserved Protein Domain Family
ACT_7
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pfam13840: ACT_7 (This model is not part of the current CDD release)
ACT domain
The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding.
Links
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Statistics
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PSSM-Id: 520933
Aligned: 116 rows
Threshold Bit Score: 48.675
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5GV2_C       277 SSGELWRMVRIGGQ-----PLgFdECGIVAQIAGPLAAADISAYYISTFNFDHALVPEDGIGSVIEVLQR 341 human
6_pfamImport   1 LLPSPFLSLIVDSDg----SGd--KLSRILELTKPLSEHDISIFYISSHFNDIVLIPHAAKEKVEQILTA 64 
Q5A0V4       146 llPEKYLCLSVDCD-----GS-SdNSLRILELTKPLSENNISLFFISSHFNDIVLIPYDLKQKVINILTk 209 Candida albicans
Q6BQ30       202 LIDEFFLSLLIDSDg----SFd--NSSQILELTKPLSENDISLFFLSSHFSNIVLIPYNLKEKVIAILSK 265 Debaryomyces hansenii
5_pfamImport   1 VISESFLSLQVDSDg----SFd--NSLRILELTKPLSENNISLFFLSSHFSDIVLFPASLKEKVISILTK 64 
XP_001482450 144 LIHETYINLQMDSDg----Sd---KSSQIIKLTQPLSENGISLFFISSHFGDIVLIPHRYKEKVLDILTE 206
XP_003006171 114 LSPDTYLVLSVISGggggaDTd--IVARILDLTAPLALAGIPIFFISTYYSDFILVPAKDRATVLAALTA 181
XP_001911663 100 ISKDDYVVFSVISVg-----Md--AGSRVADLTSPLALANIPLFFITTYYSDFILVPVKDRQAVEKTLLS 162
Q2HBG1        97 ISKDTYIALSVYGSg-----Md--AGSRVADLTSPLALANISIFFITTYYSDFILIPTKDRQAVVETLLS 159 Chaetomium globosum CBS 1...
XP_002549486 149 LLPETYLSLCVDSDg----DTd--ASWRILELTKPLSENNISLFFISSYFNNVVLIPYVLKDRVVSILRR 212
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