Conserved Protein Domain Family
PC-Esterase

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pfam13839: PC-Esterase (This model is not part of the current CDD release)
GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p
The PC-Esterase family is comprised of Cas1p, the Homo sapiens C7orf58, Arabidopsis thaliana PMR5 and a group of plant freezing resistance/cold acclimatization proteins typified by Arabidopsis thaliana ESKIMO1, animal FAM55D proteins, and animal FAM113 proteins. The PC-Esterase family has features that are both similar and different from the canonical GDSL/SGNH superfamily. The members of this family are predicted to have Acyl esterase activity and predicted to modify cell-surface biopolymers such as glycans and glycoproteins. The Cas1p protein has a Cas1_AcylT domain, in addition, with the opposing acyltransferase activity. The C7orf58 family has a ATP-Grasp domain fused to the PC-Esterase and is the first identified secreted tubulin-tyrosine ligase like enzyme in eukaryotes. The plant family with PMR5, ESK1, TBL3 etc have a N-terminal C rich potential sugar binding domain followed by PC-Esterase domain.
Statistics
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PSSM-Id: 520932
Aligned: 162 rows
Threshold Bit Score: 263.66
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002438125  137 LPAFDAAAFLSSVRGKHVAFVGDSMARNQAQSLVCLLVGG-----AGvPHRVVYrdp-----dyPRKFNLWRYAFPAHDV 206
ERN13149       16 LPTIDPFGFLGLMRNKRIGFVGDSLNENFLVSFLCIL--R-----IA-DETARk---------wKRNGAWRGGYFPKFNA 78 
18_pfamImport   1 VPRIDAAGFLAAARGRRVGLVGDSLSENLAVALLCALRSA--------DPSARRw---------KRRGAWRGGYFPREDV 63 
Q6ZGL3        102 VPRIDAAEFLAVARGRRIGLVGDSLSENLVVALLCALRSAdg--gAS-KWKRRGawrg---gyfPRDDVIVA--YHRAVL 173 Japanese rice
XP_002988168  102 LPAVDPAGFLAAMRGRRLGFVGDSLNENFLVSLLCVLRRG--------DPTARk---------wKRKGAWRGAFFPSFNV 164
EFJ25261       82 LPGFDSTQLLHRLRNKTIAFVGDSLGRQQYQSMICMLVGDasmpkIT-DVSIEYg---------LVTKGEGAQRFAATNT 151
EFJ18125       54 LPPFDGRAFLSRWKNKTIAFVGDSLGRQQFQSLLCMITRGkd-dmVAtDAGQEYgfdk--rptwSLRPNGWAYRFTETNT 130
XP_010323348  175 MPDFNGSEFLKRMQDKTIAFIGDSLGRQQFQSLMCMATGGe---dMP-EVENVGwkyglvkprgAIRPEGWAYRFPNTNT 250
XP_004973618  167 MPEFEASQFLRRMQDKTIAYVGDSLGRQMFQSMMCMVTGGkqrpdVE-DVGAEYgfvl---apgAKRPDGWAYRFPSTNT 242
CBI21583       26 MPEFKGAAFLRKMQDKTIAFIGDSLGRQQFQSLMCMVTGGeenldVE-DVGEEYglvr---tagHYRPDGWAYRFPSTNS 101
XP_002438125  207 TVSFYWAPFIARATgkal-----ndsLPQNMNH---VHLDA--LDDRwVADADGM----DVVVLSIAHWPLNGAIYYNGS 272
ERN13149       79 TVAYHRAVLLAKYQwqpl----nsleENQLKGI---YKVDV--DIP--ADDWIGVtdfyDVLVFNTGHWWGIDKFPKETP 147
18_pfamImport  64 TVAFHRAVLLAKYTwqpve--speevEKDGRKGiyrVDVDI--PADEwINVTKFY----DVLIVNTGHWWGTYKFPKETP 135
Q6ZGL3        174 LAKYTWQPVENSKEl----------hKDGIKGTy-rVDVDI--PADEwVNVTRFY----DVLIFNTGHWWGLDKFPKETP 236 Japanese rice
XP_002988168  165 TIGYHRAVLLAQYRelqpsdlpgplkNTKLKKA---FRVDVdvPAPDwANVLSFY----DVFIFNTGHWWSRDKFPDDEP 237
EFJ25261      152 TVLFHWSASLGDPQp-----------LEAGLWA---LHLDR--APGFlARNAQRL----DVVIVNTGHHWNRGKIRANKW 211
EFJ18125      131 TILFYWSASLCKIKlyn-------vtDPSSAAA---MHLDR--PVDFlKRNVARM----DLVILNTGHHWNSGKINGNKW 194
XP_010323348  251 TILYYWSASLCGIEpfn-------vtDPATKSA---MNLDQ--PPAFlRKYLDQF----DVVVLNTGHHWNRGKINANRW 314
XP_004973618  243 TILYHWSSTLCDLEpln-------psDHATSYA---MHLDR--PPAFlKNNLHRF----HVLILNTGHHWNRGKLKANKW 306
CBI21583      102 TILYYWSATLCDLEpln-------vsDANTPVA---MHLDR--PPAFlSLFLPRF----DVVVLNTGHHWNRGKLRANRW 165
XP_002438125  273 ARIGhhahreldPSED-IGYA-W---P-MKVAYRMALDRLMTTSSGGGR-A-P-RT--VVIATFSPGHFEGNTLTT--MC 339
ERN13149      148 LVFY--------KNGKaINPP-L---G-ILDGLKVVLNNMISYIDREVP-K-E-KL--KFWRTQSPRHFHGGDWNEngTC 209
18_pfamImport 136 LLFY--------RGGEpIEPP-L---S-IHDGMKVVIKSMASYIDREMP-S-S-RTl-KLWRSQSPRHFDGGEWDHngSC 198
Q6ZGL3        237 LVFY--------RGGKpIEPP-L---G-IYDGLKVVLKSMASYIEREVP-S-K-TL--KLWRSQSPRHFYGGEWDHngSC 298 Japanese rice
XP_002988168  238 LVFYr-------RGKP-ILPP-L---G-MREGLSAVLRHMVPRIEAALP-S-T-AL--ALWRLQSPRHFEGGEWNQngSC 299
EFJ25261      212 --VL--------HVDG-KVAN-L---R-VDAARRIALTSAARWLGEQRE-R-I-RG---FVRSLSPRHFRGGDWNSggRC 269
EFJ18125      195 EMYV--------GGKKvALKG-SrfaS-VSYSHQFAVKKVVRWLDRQIG-ArP-ELr-GVLTALSPRHFMNGDWNSggRC 261
XP_010323348  315 VMHV--------NGKPvVDRKlA---Q-IGNAKNFTVYSIARWLDSQIA-S-RpQLk-GFFRTISPRHFSNGDWNTggRC 379
XP_004973618  307 EMYL--------GGAPnNNRN-I---AvIWKAKNFTIHSVINWLDAQLP-N-H-PQlkVFYRSISPRHFFNGDWNTggRC 371
CBI21583      166 EMFVng----rpN-EDrKIAD-M---G-NAKDF--AIRSTARWLDSQLAlQ-P-RLk-AFFRTISPRHFQNGEWNTggSC 230
XP_002438125  340 P-RKEPYKEG-EKEp------RHLDMElVGL---VYEEVEaararngaggeaaggGAGARVEVLDVTKLAVMRPDGHPGL 408
ERN13149      210 L-FENPLNNN-QLDiwfdprkRGVNKEaR-L---MNSIVKh-------------aLLGSSIHLLDLAHLSEFRADAHPAI 270
18_pfamImport 199 V-TGRLLEED-ELE-------SWFDPRhGGV---NKDARTvnma-------iqeaLAGSEFRLVNLTFMSEFRADGHPAT 259
Q6ZGL3        299 V-SDRLLQEH-ELDlwfdprfGGVNKEaR-L---VNSAIQe-------------aLIGTDIQLLNLTYMSEFRADAHPAI 359 Japanese rice
XP_002988168  300 MsETLLSDQErERWf-----sSGTNSEaREIntlIQEVLQ----------------TSQKFRVLNITPLSEYRRDAHPAI 358
EFJ25261      270 D-GIREIEEEeELGg------DLIAQEaVRS---TNG----------------------AVTLLEISNLSRTRGEAHISS 317
EFJ18125      262 D-NIKAFGV----D-------VSNRPSrDVL---SEEAVA-----------------NTRVELLNITHLSQFRGEAHLSR 309
XP_010323348  380 D-NTIPLTKGnEVQ-------QEESS--DPV---IGDAVK-----------------GTKVKLLDITALSELRDEGHISH 429
XP_004973618  372 D-NTNPLAKG-SGI-------HLNHSEdTDA---EGA------------------VRGTRINLLDVTALSRLRDEGHISR 421
CBI21583      231 D-SITPLTGGsEVG---------EEESrDPV---IANAVK-----------------GTKIKLLDITAISQLRDEAHISR 280
XP_002438125  409 YMHrdpfahggpqpWMSSDCVHFCLPGPVDTFNEILQQI 447
ERN13149      271 WLGkkd-----avaVWGQDCMHWCLPGVPDTWVDILSTL 304
18_pfamImport 260 WLGkkd-----avaVYGQDCMHWCVPGVPDTWVDILAAQ 293
Q6ZGL3        360 WLGkkd-----avaVWGQDCMHWCLPGVPDTWVDILAAR 393 Japanese rice
XP_002988168  359 WLGrkd-----ahlTWGQDCLHWCLPGLPDTWVDILCEI 392
EFJ25261      318 AFVgssss-sssssPRQQDCLHWCLPGVPDTWNELLFAH 355
EFJ18125      310 FTAna--------rPGIQDCLHWCLPGVPDVWNEILNAQ 340
XP_010323348  430 YSLka--------sEGINDCLHWCLPGIPDTWNELLYAQ 460
XP_004973618  422 YSIka--------tPGVQDCLHWCLPGVPDTWNEILAAQ 452
CBI21583      281 YSIka--------tEGVWDCLHWCLPGIPDTWNELLVAQ 311
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