Conserved Protein Domain Family
NCOA6_TRADD-N
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pfam13820: NCOA6_TRADD-N (This model is not part of the current CDD release)
Nuclear receptor coactivator 6, TRADD-N domain
This entry represents the TRADD-N domain found in the nuclear receptor coactivator 6 (NCOA6), which belong to the TRADD-N domain superfamily. NCOA6 is a component of SET domain histone methyltransferase complexes such as the ASCOM coactivator, involved in nuclear hormone receptor transactivation.
Links
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Statistics
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PSSM-Id: 520921
Aligned: 7 rows
Threshold Bit Score: 144.995
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008108217   47 TIFVAFKGNIDDDDFKQKLNIILDNVP--------DLLNMES-DKLRLRKVEPWNSVRVTFNIPREAAERLRMLAQNNNQ 117 
1_pfamImport    1 ETVVTCEGDLGDPEFPEKLDTIVDSLK--------ALLSKEKgEDLKVDKVEPWNSVRVTFSIPREAALRLRELAAQGSP 72  
EDK42274      291 NVFLAYIAGLQ--EEKYSLDSIREWVKklyapiinELIGTEK----------PLQKVAMA-----ELESLFRLATNLNNL 353 
EEC02406       11 TTVLTCEGDLRDPAFPGRLQSLVLRLR--------ELISDEE-KPFWVKKVEPWNSVRVTFTLPREAALRLRQLAERGDR 81  
XP_005986810   48 TIFIAFKGNMEDADLQQKLDKIIENVP--------CLLNMES-RKLKMQKVEPWNSVRVTFNIPREAADRLRLLAQNNNQ 118 
XP_015151765   57 TIFVAFKGDIGDRDFEQKLSVILENVP--------GLLHMES-NKLKLQKIEPWNSVRVTFNIPREAAERLRILAQNNNQ 127  chicken
XP_047296023   47 TIFVAFKGNIDDKDFKWKLDAILKNVP--------NLLHMES-SKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQ 117  human

XP_008108217  118 QLRDLGILSVQIEGEGAINLSL---AQNRGQDVRINGPVGQGNSVRMETGFSMPGNQGli-----------rINNPAAVM 183 
1_pfamImport   73 TLTQLGILSVQVEGDQVISLRIasrFGGDAQEIVLHSGTAQDGGAKSQGDATNNTATA--------------DTNPSTAL 138 
EDK42274      354 SYKELDLRVTQIQSDPFV-------VQISLDNVIL-GLGTSLNNFDEAQDKAAMGIIGdkakvaqiftmiirNYVQNSER 425 
EEC02406       82 ALRDLGILSVQLEGDQIISLTLagrYGEPPKEIIL-----QKAAGEAEPGSPSSSPAGp------------sSPVPGTGR 144 
XP_005986810  119 QLRDLGILSVQIEGEGAINLAL---VQNRGQEVRINGPMGAANQIRMDPGLPMQGGPGli-----------rVNNPVAPG 184 
XP_015151765  128 QLRDLGILSVQIEGEGAINLAL---AQNRSQDVRINGPLGANNSVRMETGFPMQGGQGli-----------rMSNAAAVM 193  chicken
XP_047296023  118 QLRDLGILSVQIEGEGAINLAL---AQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGii-----------rMNNPATVM 183  human

XP_008108217  184 MQQSGNV 190 
1_pfamImport  139 PGPSNAT 145 
EDK42274      426 LVEHGST 432 
EEC02406      145 PGPSGTA 151 
XP_005986810  185 MSQAGNV 191 
XP_015151765  194 MSQSGSV 200  chicken
XP_047296023  184 IPPGGNV 190  human
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