Conserved Protein Domain Family
Pil1
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pfam13805: Pil1 
Eisosome component PIL1
In the budding yeast, S. cerevisiae, Pil1 and another cytoplasmic protein, Lsp1, together form large immobile assemblies at the plasma membrane that mark sites for endocytosis, called eisosomes. Endocytosis functions to recycle plasma membrane components, to regulate cell-surface expression of signalling receptors and to internalize nutrients in all eukaryotic cells.
Links
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Statistics
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PSSM-Id: 404658
Aligned: 22 rows
Threshold Bit Score: 329.301
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2HFB9              2 LNRALSIRSSNrss---ngtTSTTTSSgtttTTASS------ShRkPFSFHSLRGA--SQ------PALSKRLYRLIKSA 64  Chaetomium...
EEQ85460            1 MHRTYSMRQSR---------TPTASQL----ENPPPppsttkTnR-LFGRTSLGHAfrKQtagafgPDLSRKLSQLVKME 66 
EOD43544           40 rNRSLSIRSNKkdg--------------sgdSTGNSksssaaKhR--FTMASLRGM--QQ------PELSKRLYKLIKSE 95 
EHA57322            1 MNRSFSIRSSKgqr--------------sgaQNGGGah--anRnRgGF-LKSLRGPlnNQ------PELSRRLYKLIKSE 57 
XP_009221403        1 MNRSFSIRSSKsqrs-sggsGHGFGGGgggaSNGGG------GrKgGFSFTSLRGTm-QQ------PELSRRLYKLIKSE 66 
XP_007793341        5 rNRALSIRSNKgg------sSSTTGGT----TTAGG--------RkGFSFSSLRGS--IQ------PELSRRLYRLIKST 58 
ENH78253           23 PNRALSIRSNRrr-----------sgS----QNGPK--------RsGFSFNSLRGN--TQ------PELSRKLYRLIKSQ 71 
XP_003346283       15 wNRALSIRSNNrss---gngTSTNSSS----HHHSS--------RrGFNLSSLRGT--IQ------PEMSKKLYRLIKSE 71 
XP_003652485        2 LNRALSIRSSNrss---nstTSTHSGA----TAASSrhhhqhQhHkPFSLTSLRGS--TQ------PELAKRLYRLIKTG 66 
jgi:MYCTH_2313564   2 MNRALSIRSSNrsssgtanpTSTTSSH----QSGAS------HhRkLFSFHSLRDA--TH------PPLSKRLHRLIKSE 63 

Q2HFB9             65 NTLVSAHETAARERLSIATQLSEWGEQTpaaytvagg---------sggggsgnDAAVSDVSDKIGVLLSELGEQEEAYA 135 Chaetomium...
EEQ85460           67 KNVMRSMELVGRERMEAAQQLSFWGESC--------------------------DDDVSDVTDKLGVLIYEMGELEDQFV 120
EOD43544           96 NHAIGAHESAGRERASIAAQLSEWGEATg-------------------------DDAVSDVSDKLGVLMAEMAEQEDGFA 150
EHA57322           58 NTLVGAHETAGRERISIATQLSEWGERTp-------------------------DPAVADLSDKLGVVLAEVGEQEDAYA 112
XP_009221403       67 NSLVSAHEAAGRERLSIATQLSEWGEKTg-------------------------DAAVSDLSDKLGVVLSEMGEQEDAYA 121
XP_007793341       59 NNLVTAHEAAGRERVAIATQLSEWGEQTr-------------------------DEAVSDVSDKVGVILSEIGEQEDTYA 113
ENH78253           72 NNLITAHETAGRERVSIATQLSEWGEQTq-------------------------DESLSDVSDKVGVILSELGEQEDQYA 126
XP_003346283       72 NNLISAHETAAKERLSIAQQLSEWGEQTs-------------------------DEGISDISDKVGVILSELGEQEDNYA 126
XP_003652485       67 NSLIAAHSAAARERASIATQLSEWGEQTg-------------------------DAAVSDVSDKVGVVLCELGEQEEAYA 121
jgi:MYCTH_2313564  64 NILVSAYETAARERISIATQLSEWGEQRqqpqqqqqhpasstspqdgsgggagaDPAVSDISDKIGVLLSELGEQEEAYA 143

Q2HFB9            136 ARLDESRAVLKVVRNTEKSVQPSRDGKRKVAEEIQRLKIKEPQSARLVTLEQELVRAEAENLVAEAQLGNVTRQKLKEAY 215 Chaetomium...
EEQ85460          121 DRYDQYRVTMKSIRNIEASVQPSRDRKQKITDQIAHLKYKEPNSPRIVVLEQELVRAEAESLVAEAQLSNITREKVKAAF 200
EOD43544          151 QGLEDYRGVLKQIRNTESSVQPSRDHKAKVADEIAKLKYKEPSNTKIVQLEQELVRAEAQSLVAEAQLTNITRQKFKEAY 230
EHA57322          113 HAIEDSRSMLKHIRNTERSVQPSRESRGKLVDEIARLKSKEPQSARLVILEQELVRAEAENLVAEAQLFNMTRKSLKAAY 192
XP_009221403      122 HALEDSRATLKRIRNTERSVQPSRDGRARIADEIARIKSREPQSAKLVILEQELVRAEAENLVAEAQLVNITRKSLKEAY 201
XP_007793341      114 HGLDEAREHLKAIRNTERSVQPSRDGRDKIADEIQRLKIREPQSTRLVVLEQELVRAEAENLVAEAQLTNITRKKLKEAY 193
ENH78253          127 HAIDDARGVLKTIRNTEKSVQPSRDGKEKILDEMAKLKSKEPQSAKLVVLEQELVRAEAENLVAEAQLTNISRQKLKEAY 206
XP_003346283      127 HALDDSRGTLKAIRNTEKSVQPSRDGKNKIADEIAKLKSKEPESTRLVVLEQELVRAEAENLVAEAQLSNITRQKLKEAY 206
XP_003652485      122 AALDAGRAVLKVVRDTERSVAPSREGRRRIADEIARIKAREPQSARLVTLEQELVRAEAENLVAEAQLGNVTRQKFREAY 201
jgi:MYCTH_2313564 144 ARLDESRAALKVVRDTERSVQPSRDGKHRVADEIHRLKAREPQSARLVTLEQELVRAEAENLVAEAQLGNVTRQKLKEAY 223

Q2HFB9            216 TVDFLATIERAEKQAILARHGLRLLQLLDDTPVVPGDVRPPYAHASQTRQILNDAEDDLREWRLD 280 Chaetomium globosum CBS 1...
EEQ85460          201 AYQFDALREHCEKLAIIAGYGKHLLELIDDTPVTPGETRNAYDGYDASRAIIQDCEDALTHWVSS 265
EOD43544          231 DIHLAAVIERAEKQALLAKHARRVLNLLDDSPIVPGESHAPFAHEHAGRDILNDAEDELRAWTPR 295
EHA57322          193 EAEFLATIERAEKQIILARHGRRLLELLDEEAVVPGAAIPEYHGAADSRQIVCDCEDDLGNWRPD 257
XP_009221403      202 DAELLATIERAEKQIILARHGRRLLELLDDDPVIPGAELAPYGGAPAGRQILCDCEDDLRDWRPg 266
XP_007793341      194 EAEFAATIERAEKQILLAKHGRRLLALLDDDPVTPGDARRTYTHGAQARQVLNDAEDDLKSWALQ 258
ENH78253          207 EAEFAATIERAAKQIILAKHGRRLLQLLDEAPVVPGDVHRTYRHGQQARQILNDAEDDLRDWRPD 271
XP_003346283      207 TAEFLATIERAEKQVILARHGLRLLNLLDDTPIVPGDAGIPYTQGHQARQILNDAEDDLRDWRPT 271
XP_003652485      202 TAEFLATIERAEKQAILARHGLRLLQLLDDAPVVPGDARPAYTHAPQARQILNDAEDDLREWRLD 266
jgi:MYCTH_2313564 224 TLDFLATIERAEKQAILARHGLRLLQLLNDTPVVPGDVRPPYTHAAQARQVLNDAEDDLREWRLD 288
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