8GE0,4NN2


Conserved Protein Domain Family
zf-HC5HC2H
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pfam13771: zf-HC5HC2H (This model is not part of the current CDD release)
PHD-like zinc-binding domain
The members of this family are annotated as containing PHD domain, but the zinc-binding region here is not typical of PHD domains. The conformation here is a well-conserved cysteine-histidine rich region spanning 90 residues, where the Cys and His are arranged as HxxC(31)CxxC(6)CxxCxxxxCxxxxHxxC (21)CxxH.
Links
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Statistics
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PSSM-Id: 520898
Aligned: 80 rows
Threshold Bit Score: 56.5816
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8GE0_A        96 HVSCALWIPEVSI-GSPEkm---epITKVSHIPSSRWALVCSLCNEKfGASIQCSVKNCRTAFHVTCAFDRGLEMKTila 171 human
Q7PZ79        84 HYFCLLSGTNIPQnGSTPagiagfkISDVLSSYAEYREKQCYYCRHP-SAPVECAQAGCGRRYHYICGYNNSCVTQF--- 159 Anopheles gambi...
EDW52436      34 HYFCLLLSTHLPQrGGDSsgilgflLRDIREEAAAAEKRKCWYCNKI-GASLQCDR--CRTLFHLKCGLENRAVFEF--- 107
XP_002056793  34 HYYCLLLSTNLPQrGGDSsgilgflLRDIRQEAAAAQQRKCAFCKER-GASVVCYK--CRIVFHMPCGLENRCIYQF--- 107
XP_001954737  33 HYFCLLLSTKLPQrGDDSvgilgflLTDIRKEIAQARHRKCEYCSKM-GANVSCHK--CGDLFHMPCAVTNRCTIEF--- 106
A0E764       283 HEMCGLWSQNLVFfSNLEqc----dPKNIDDEVEKSKKTKCFLCSRS-GATICCAV--CPQSFHFTCLMKSSQTGKL--- 352 Paramecium tetr...
A0C6G8       273 HEMCGLWSQNLVFfDKQGqc----dPNNLDEEVTKSKQTKCFLCSRP-GATVCCAV--CPVAFHFTCLMNSSQTGKLv-- 343 Paramecium tetr...
A0BQ51       183 HEMCLLWSN-RVQvDYNTml---vdIATLIQAVQFAQAQMCRYCGSI-GASLKCNKAECHVHYHFNCLKQVRLMGLQ--- 254 Paramecium tetr...
A0D3V4       376 HDL-CVYWSSMVDcDEVKgs---vdFESLCNAVRIAYDTFCYLCKRR-GATMKCNNKDCNVWIHYYCWKELDPSNQY--- 447 Paramecium tetr...
A0BKY5       276 HDLC-VFWSSLVEcDEKKgt---idFESLQEVVKISQETYCYLCKRK-GPTLKCNDENCQIWIQYYCWKKLEPSQQY--- 347 Paramecium tetr...

8GE0_A       172 ENdeVKFKSYCPKH 185 human
Q7PZ79       160 V---GEFRSYCDQH 170 Anopheles gambiae str. PEST
EDW52436     108 C---GQYKSYCYKC 118
XP_002056793 108 C---DEFRSYCEHC 118
XP_001954737 107 C---GNFISYCDTC 117
A0E764       353 Ie--NQFKFFCDKH 364 Paramecium tetraurelia
A0C6G8       344 ---eSQFKFFCETH 354 Paramecium tetraurelia
A0BQ51       255 LDheQKFRFFCEDH 268 Paramecium tetraurelia
A0D3V4       448 -LdnERFRMLCHRH 460 Paramecium tetraurelia
A0BKY5       348 -LdnQKFRMLCYQH 360 Paramecium tetraurelia
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