Conserved Protein Domain Family
WxL
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pfam13731: WxL (This model is not part of the current CDD release)
WxL domain surface cell wall-binding
The WxL motif appears in two or three copies in these bacterial proteins and confers a cell surface localisation function. It seems likely that this region is the cell wall-binding domain of gram-positive bacteria, and may interact with the peptidoglycan.
Links
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Statistics
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PSSM-Id: 520884
Aligned: 53 rows
Threshold Bit Score: 106.698
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q837W5         28 AQVASIQSNADITFALdNT---------VTPP-VN---PTNPsqpvtpnpadpHQPG--TAGP-LSIDYVS-NIHFGSK- 89   Enterococcus ...
Q82ZB3         26 QATTTGNTPVTAAFEGgTLpdgn-gdanTVDPd--------P-------------SG--SNSN-FDLLFIPrEFNFGKL- 79   Enterococcus ...
Q82ZI1       1241 GNYSGVSTSATVRVKDnDQa--------IVTP---------T-----------------AEGF-ISVP----TFNFGQVg 1281 Enterococcus ...
WP_011102288   39 TANTTGTTDIQAMFEGnSS---------PVSP-VN---PDNPnkpd---nsgdSGNGakAGGG-LSLIYVSnKLDFGSH- 100  Lactiplantiba...
WP_011101992   29 GENRSGTTNATATFTAnTTn--------PVDP-VD---PTDPtkpldpkpgdgDNGA--NSGAgLSLIYAPgKLDFGSH- 93   Lactiplantiba...
WP_005226152   26 QSSLETTTDNVVGFTSdGSdltv-vqppVVHPeVEtiePTPP--------------G--QTGP-FTIAYAPqTFDFGQN- 86   Enterococcus
WP_015509008   35 tplfeVETPNEVTFTEgDDdvddvenplEYPP-VIi-dPL-P-----------------VKGP-LTIVYVPeMFDFGQQ- 92   Enterococcus ...
4_pfamImport    1 --TKDLTSEFTVTVTQpG----------ASKP-ID---PTNPqpgne-tdaenEGTG--NIGY-LRVDYAPsNFDFGKV- 59  
WP_003640248   23 TADSTANTTTNLELTEnTG---------PTIP-VD---PTNPanpqvpedpdnPATG--NTGA-LTLDVAPrTFDFGSVq 86   Lactiplantiba...
WP_003643001   32 TLPSTGKSQADVSFTSnGG---------STNP-VD---PDNPdnp------ggGGTG--NNGP-LSLDAVPtYLNFGTH- 88   Lactiplantiba...

Q837W5         90 QI-QAGTA---IYSAQLD----------------QVQNSTGDLISVPNY---VQVTDKRGLN-LG-WKLSVKQSaQFAt- 143  Enterococcus ...
Q82ZB3         80 SI--SDDL---TKPILNQ----------------------RDPEATNGHtemIGVGDVRGGK-EG-WHLTAQSNg----- 125  Enterococcus ...
Q82ZI1       1282 VAgSTQQH---SLKKAAD---------------------YYGNGTRNPY---LRIKKTQ----AN-WSLTAQLS-QPKsa 1328 Enterococcus ...
WP_011102288  101 EIdVLNPE---TYTAAET---------------------DSDLSGLWNKkavTEVSDVRGSN-AG-WTLAVAGS-SLT-- 151  Lactiplantiba...
WP_011101992   94 EIdVINNQ---SYKALTGsdg-----------stVTMGSTSKVG--------LQVSDQRGTN-AG-WTLSVAAAdg---- 145  Lactiplantiba...
WP_005226152   87 AI-STSDR---WYSIVAD------------------ERNLADQSGTTPYvsfAQVQDTRGTH-AG-WTLNVSLT-DFT-- 139  Enterococcus
WP_015509008   93 AI-TSSAA---EYSVIAEmqnv---------deeHPLAIDNELTGEVPYvsfAQVSDTRGNS-AAdWTLSLALS-EFIg- 156  Enterococcus ...
4_pfamImport   60 ----TTSFlnkTYQANQP-------------------LSVSGKTLTQQW---IQVSDTRLSD-NG-WTLSVSQStPFI-- 109 
WP_003640248   87 TY--AAEH---TYKATTT-------------------------TNGQQY---LQVTDNRGTDeQG-WTVTVEQDqDLTet 132  Lactiplantiba...
WP_003643001   89 TQ-PNVDT---AYTLLSKdasqeslatanddktqNVTTSGKKNGNDIIY---TQVSDSRGTG-AG-WQLKAQLS-DITas 158  Lactiplantiba...

Q837W5        144 ----sDSTPAVLDN----ASLTF-----------------LAATPNSTQLLSLap--------------lTVPVTL-DPT 183  Enterococcus ...
Q82ZB3        126 ----lKLGTESLQGnikvALITQldleyeatsnsyvalttAVSTPEVRPQLAA-----------------PQNWTL--DL 182  Enterococcus ...
Q82ZI1       1329 tdslpTATRLLLGA----APVSS-----------------FSNYNQPTELKNAvg--------------tTSAISL--NA 1371 Enterococcus ...
WP_011102288  152 -----GTDGSVMKG----ATLQLpkgtv--------tnsgATNNG-------------------------VQSTEAlNVL 189  Lactiplantiba...
WP_011101992  146 ----tDGNLSTLKG----ATVSLpa-------------gtVISSGSEASNGSTggngavgqaveldlgsqASTSAGaSFT 204  Lactiplantiba...
WP_005226152  140 -----SESGDVLTG----AKIKLanpei--------vfnkGEGDRDLQPSAVIn---------------nEEQNALiLDV 187  Enterococcus
WP_015509008  157 -----KTTDDVLYG----AQLHFidpqi--------khndGTGPADEAPVAPVtn--------------gDRVILNaDTD 205  Enterococcus ...
4_pfamImport  110 -----GSDGSTLEG----AQLKIpkgk---------iyntASNSEPIIDNSII-----------------SRGVSL---- 150 
WP_003640248  133 ----sGSSPHVLTG----TTIHVpa--------------gIARNSLATDPTAVdt--------------nLTTTAAdVTN 176  Lactiplantiba...
WP_003643001  159 dgqvlTNASVVLSG----GTPQYlt-------------geANQQSWVTAADANqa--------------tVATPIVlNAG 207  Lactiplantiba...

Q837W5        184 GAATSPVA--TAA----LSTGMGTWTLAFGSGATA--------------AQGIQLTVPATTKKVAAkQYKTTLTWILDD 242  Enterococcus f...
Q82ZB3        183 GGEAQLMA--NAA----AGQGQGLWQFSLF-------------------NTALNITTPANNIKAGA--YTGSITWNLVA 234  Enterococcus f...
Q82ZI1       1372 NNTATRII--ANQ----QFTGSNIYQLDFT-------------------FNNVKLEVPANQGVKGQ-QYQAAITWNLVT 1424 Enterococcus f...
WP_011102288  190 DGNSATVL--SAA----KDHGAGVTVDQID-------------------PSNVKLTVPANTAKAQG--YQTTLNWSLSD 241  Lactiplantibac...
WP_011101992  205 GTTSGNVM--TAA----DKSGAGITSDLLD-------------------PAAVKLNVVANTAAATT--YKGVLNWTLTS 256  Lactiplantibac...
WP_005226152  188 NDQDIPVM--RAS----VGQGAGASSIYWGDQEKLteqnlnkqegeiirNDDIQLFVPGSTTQLAT-NYTAEMTWTLTA 259  Enterococcus
WP_015509008  206 LASSIPVM--TAG----ANQGQGRSSVFWGDQDDLmkqyetegttgtilNDRIQLHLPSAATPQQD-TYEATLTWLLST 277  Enterococcus c...
4_pfamImport  151 SETPTAILttPKV----NASGKNITTNVWD-------------------PTQVSLYVPGGSAKNKV-RYQTTINWSLVT 205 
WP_003640248  177 TSGAVTVFntTAT----TGAGKGTSVKVWD-------------------PSDVTLTIPKNTAKPGA--YSNTLTWTLTA 230  Lactiplantibac...
WP_003643001  208 ASSTTDVAtaTAGskvgDGQGMGVNQQYWN-------------------INNVQLHVKGGHAAAKN--YSGNIVWTLNS 265  Lactiplantibac...
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