Conserved Protein Domain Family
TRC8_N

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pfam13705: TRC8_N (This model is not part of the current CDD release)
TRC8 N-terminal domain
This region is found at the N-terminus of the TRC8 protein. TRC8 is an E3 ubiquitin-protein ligase also known as RNF139. This region contains 12 transmembrane domains. This region has been suggested to contain a sterol sensing domain. It has been found that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG.
Statistics
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PSSM-Id: 520872
Aligned: 31 rows
Threshold Bit Score: 455.932
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_032584257    8 LGLVDVMMRVPPIIVIDEILKIG----MGVPIqlgaskaytvesdaikssqsdashsadtfatikaffgigsedsattss 83 
XP_002639063   49 IMVLETGLRLPGLLFIELLWRYQgvsfediqdgvik-------------------------------------------- 84 
Q5SWK7          8 EAVLNVALRVPSIMLLDVLYRWD--------------------------------------------------------- 30  house mouse
10_pfamImport   1 EEIANVALRVPSIMVLDLLYKCD--------------------------------------------------------- 23 
XP_001342512    5 EEVANVVLRVPSILVLDMLYKCD--------------------------------------------------------- 27 
XP_004082860    5 EELANIALRVPSMLVLDLLYRCDv---EGLTE------------------------------------------------ 33 
XP_008121044    6 EKLANVVLRVPSIVLLDLLYRWD------VQA------------------------------------------------ 31 
XP_015784398   11 DAALAVVLRTPGLFIIEYWWQNE--------------------------------------------------------- 33 
6_pfamImport    1 LAALDVALRVPCIFIIDAIFNSYydagFGWAG------------------------------------------------ 32 
XP_014349726   27 EEVGNIVLRVPSLILLNLLYNVD--------------------------------------------------------- 49  coelacanth
XP_032584257   84 lishrnqailehtienasksaqasgmlsnnfnnimdelandsllanmlSITTVK-------------FVVCL-------- 142
XP_002639063   85 ------------------------------------qmplsyfdiptmLDFVHRrnfd-----hhaaIILSY-------- 115
Q5SWK7         31 -------------------------------------------------VSSFFqqiqrs--slnnnPLFQYkylalnmh 59  house mouse
10_pfamImport  24 -------------------------------------------------VESFTeqlka----rnedMLFKYkyviwnvy 50 
XP_001342512   28 -------------------------------------------------IDSFTdhlka----rtedMLFKYkyviwniy 54 
XP_004082860   34 ------------------------------------------------HLKAKNd-----------nMLFKYkyviwniy 54 
XP_008121044   32 ------------------------------------------------FAEGLRpnaqhlylqrhhlWNIYY-------- 55 
XP_015784398   34 ----------------------------------------------------KNnflsfg--desnyILTILn------- 52 
6_pfamImport   33 --------------------------------------------------AIGK-------------LLIRI-------- 41 
XP_014349726   50 -------------------------------------------------VQVLIqqlra----rsewMLFKYkflfwnly 76  coelacanth
XP_032584257  143 -LGFLCATCIFMLWTRHLVMVYMF----LTSLGLTFLSYWSNVSALELmehspcmledlLSLNTTRLLDSGGVIMSLAPH 217
XP_002639063  116 -FVIFISLMFLTLPLSRLIRMYSH----FLSIFLFGVAYKLSAIYVDLe----------LK---SNEEELKLDGLIKLER 177
Q5SWK7         60 yVGYILSVVLLTLPRQHLVQLYLY----FVTALLLYAGHQISRDYV------------------RSELESAYEGPMYLEP 117 house mouse
10_pfamImport  51 yLGHLVSVVVLVLPLRHIVKLYLY----ILTALLLYVGHQISRDYV------------------RGEIQHGYEGAVYLDA 108
XP_001342512   55 yLGHIVSVVVLLLPLGHIIQLYLH----VLCALLLYMGHQIVRDYV------------------KGEAQYGYEGVLFLDS 112
XP_004082860   55 yLGHFLNLVVLVLPLRHLVTLYLH----VLVGLLLYMGHQISKDYI------------------REELVYGYHAAAHLNA 112
XP_008121044   56 -AGHVVCVVVLLLPVRSLVKMYLY----LLTVLLLYVGHQTAWDYI------------------RHEMEHEFYGAVYQDP 112
XP_015784398   53 nIALINGFFILLLPISCIRSLYIH----FICGALLLSAHFLSHYWVRD-----------SNGDYLSQIDVVDRMASSVVH 117
6_pfamImport   42 -TGVFISIVVLLLSQRALFKFYALffavLLGVTAVLFNYYSTSH-----------------TDIYSFYYKAASGFQLLPK 103
XP_014349726   77 cGAYAFSLVVLLLPVRYLVRLYLC----ILTALLLYVGHQTSRDYV------------------QRELESAYDGTVYRDP 134 coelacanth
XP_032584257  218 ---------LIAQWVMGMLFAYIHLGPRFG------------------------------LLQKSMPIIFTSPILlAMLP 258
XP_002639063  178 hg-----fhFLAQMLLVVLQSMLLEIDGEP--------------------------------WKFALPVFALPIV-ARMG 219
Q5SWK7        118 lsmnrfttaLIGQLVVCTLCSCVMKTK-----------------------------------QIWLFSAHMLPLL-ARLC 161 house mouse
10_pfamImport 109 fafhrfvtaLTSQIILGTLCAFLMKTR-----------------------------------QVWLFSAHLLPLA-ARLC 152
XP_001342512  113 palnrfvtaLTSQIIVSTLCAFLMRTQ-----------------------------------RVWLFSAHLLPLL-ARAV 156
XP_004082860  113 safnrfvsaMTSQIILSTLCAFLMKTR-----------------------------------KVWLFSAHVLPLL-VRLW 156
XP_008121044  113 valgrfataLTSQVIVATLCAFLLRTK-----------------------------------QVWLFAAPMLPLA-ARLC 156
XP_015784398  118 nsaikqislLAVHVIIAGIVSLLLQGPRRP--------------------------------VVSAFACYSLPVI-ARIV 164
6_pfamImport  104 ngptlwmgmAFVQLIF--ILGYVKLWCIATmvlfllslvdlpffgfffsltwlnkktktiIESVQFILNLLISTN-NNLQ 180
XP_014349726  135 lavthlitaLTGHIIVSTLCSFLMKTR-----------------------------------QLWLFLAPALPLL-ARLC 178 coelacanth
XP_032584257  259 -LPPSIVDKLPVVAGLTPIILTKITLMQSAMEASRTVYNGYQYAMNFV--SNFGLSALIENEWQRLNVPNVLRVFWALRI 335
XP_002639063  220 gCPKDKLKNAHNYACTGTMVFIATYILYRGPSLIKSAKTALRQIKAVF--MVHGLADGVSVLWRRLRILELLTFTWITMF 297
Q5SWK7        162 lVPLETIVIINKFAMIFTGLEVLYFLGSNLLVPYNLAKSAYRELVQVV--EVYGLLALGMSLWNQLVVPVLFMVFWLVLF 239 house mouse
10_pfamImport 153 sAHNATLITVSSFAMVLTGVEVIIILLSNLFVPYQLARSACREILQLEl-EPYRLLAVVISLWNQFAVPVLFSVFWFVLF 231
XP_001342512  157 sVPLNWLLTLSSVSMMITGAEVAIFLLANFFVPYRLARTTYREIMDIEvtELYRLMAVGVSLWHGFAVPVLFSVFWFVLF 236
XP_004082860  157 sPPHPTLLTISSLSLGLTAAGVAVFLLSNLFVPYRLARAAFSELTQFEltEIYRFLAVGISLWNQYAVPALFSLFWCVLF 236
XP_008121044  157 cLPLQVLPTVNTFAAILTATEALYIVTSGLSVPFQLVSAAYREVTQAL--EVYNLVTLGMSLWKQLAVPLLFLVFWLALF 234
XP_015784398  165 dFSSESIEVIHHFSTAFVVITLVHYGYNQFYGLFNSFKGAFNDLLSET--RVNGFLYIIVLLWKKLFVPTHFLLFWCIAF 242
6_pfamImport  181 cFAPHVTSSVRIIQSVL------------------------------------GLNNMPPQVWKVLRFEGGVKVQQFDLV 224
XP_014349726  179 lVPLPALPMVNNFAMVLTILEVLSFAASNLFVPYNLVKHAFQVLIQVE--EVYGLVNLGRILWKQLAFPLLFLVFWLVLF 256 coelacanth
XP_032584257  336 LKGGYTLitae-----------sdvpLQLFPAMEKLLVDGCETLTAVLGMTGVISMICHYIGRSFQWYLLTYDnDEEK-- 402
XP_002639063  298 LMVLYVElidk-----------grtwSEVGRILLTGVAETTNTPITLAALAVSVSYVCKWIADLTKLVTGGARsHGHV-- 364
Q5SWK7        240 ALQIYSYfstrd---------qpasrERLLFLFLTSIAECCSTPYSLLGLVFTVSFVALGVLTLCKFYLQGYRaFMND-- 308 house mouse
10_pfamImport 232 LVQIYSYitasn---------ngialQGVLFVFLTSVSECCSSPYSLLGLTFVVSYLALGLLNLCKFYLGGYAaVQNE-- 300
XP_001342512  237 GVQLITNfgti-----------tavqQGPLLYLLTSVSECCASPYSLLGLTFVVSYTALGLLSLCKFYLGGFNaLQNH-- 303
XP_004082860  237 TVQLCSDvlsve---------tsapqSGIIFLLLTSVSECCATPYSLLGLTFVVSYLALGLLNLCKFYLGGFAaVQNE-- 305
XP_008121044  235 TLQIYALassssg--------sllshQGLIFVLLSSVAECCSTPYSLVGLTFTISYLALGLLKLCKFYLAGYGaFQNG-- 304
XP_015784398  243 LCKIYENifve------------ensQDIYGLILSSASSLCTSPLSLVSTAVTVTYISYFTLCGIKLYLWGKPdYVGRqs 310
6_pfamImport  225 SSVVPIFvyflrflvvcfsqghmlswDVFWDLSSNLIISGCDSTLTVLGMSAVISSVAHYLGLSILAFIAGSTeEEDK-- 302
XP_014349726  257 VFEISSFlkswn---------nldknQGFLFIFLTSMAKCSSTPYSLLGLAFTVSYVALVMLNLCKFYLAGYGaFPNE-- 325 coelacanth
XP_032584257  403 ---------S-----LGTVSAVLFYILALQTGLTSLAPDKRFVRLCRNLCLLVTALLHFLHNIVSPILMSLSAARNPSRK 468
XP_002639063  365 ---------La---hSGYTEAVSVVILCIQTGFLGMQVEQKTILLALVLYIVISALLQSLFEIIELVLLNLPSSPQATKS 432
Q5SWK7        309 ---------Pam--nRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIVVASILQSMLEIADPIVLALGASRDKSLW 377 house mouse
10_pfamImport 301 ---------NvmhrrRGVTEGVTLLLLALQTGLLDMQVLQRTFLLSIILFIVVTSTLQSMIEITDPIILALGASRNRSLW 371
XP_001342512  304 ---------Nvm--hRGVTEGVTLLLLALQTGLLDMAALQRCFLLFIILFIVLTSTLQSMSEITEPVVLGLGASRNRSVW 372
XP_004082860  306 ---------Nvm--hRGVTEGVTLLLLALQTGLLDMQALQRTFLLCIILFIVTTSTLQSMIEITDPIILALGASRNRSVW 374
XP_008121044  305 ---------Nvm--hRGVTEGVTLLLLALQTGLLDLQLLQRTFLLSIILFIVVTSTLQSMIEIADPVLLGLGASRNRSLW 373
XP_015784398  311 diyfnqimlHqa--hSGWEEGLITFLLAVLTGITNMQPPARMAVLTIILFVVLSSLLESMLEIAEPVILSLSTYHGRNIF 388
6_pfamImport  303 ---------R-----LGFVAPVLFFILALQTGLSSLDPEERLVRLSRNMCLLLTAILHFIHGMTDPVLMSLSASHVYTVR 368
XP_014349726  326 ---------Nvm--hRGVTEGVTLLLLSlqtglmDLQVPQRTFLLsiILFIVVTSTLQSMIEITDPIILSLGASHNRSFW 394 coelacanth
XP_032584257  469 RHVRALSVCAFLILMPLGLLYYLWTHHSPSTWLLAVTAFSVEVIVKVLVSLATYTLFLLDARRQFFWEKLDDYLYYVRAF 548
XP_002639063  433 RHARCIAIALLLVVLPFFTTRTMLAFLPIDIYTAIIIANSATVAARAIGVVLKYIVLIVETKSEEPWEGIDDMIYYIDCS 512
Q5SWK7        378 KHFRAVSLCLFLLVFPAYMAYMICQFFHMDFWLLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGT 457 house mouse
10_pfamImport 372 KHFRGLGMCLFLLVFPVFMAWKISQFFQMDFWLLILVSSCMLTSLQVTGTLLIYSLFMVELARRDPIESLDEIIYYVNAV 451
XP_001342512  373 KHLRGLSMCGFLLLFPGFMAYKISQFFNMDFWLLILVSSCMLTSLQVTGTLLIYSLFMVEVWRGSALPGLDEIVYYVNGV 452
XP_004082860  375 KHIRGLSLCLFLLVFPVFMAYRISQFFHMDFWLLILVSSCMLTSLQVTGTMLIYLLFMVELFRSDPIESLDEVIYWVHAV 454
XP_008121044  374 KHFRGVSMCLFLLVFPGFMAYKIAHFFHMDFWLLILISSCMLTSLQVMGTLFIYGLFIVELFQDAPMERMDEIIYYVNAV 453
XP_015784398  389 HHVKVLLLCAFLFFFPLHVSWVLANLFPVDFWMAVVISTSLLTSAQVLDLVVVHCLLWYDAVRHEPWAPLDEMVYYVRSA 468
6_pfamImport  369 RHFPVLLVSIALFVLPVVLSYALWHNYALNTWLFAVTAFCVELCLKVVVSLTVYGLFMVDGFSNVLWEKLDDYVYYVRST 448
XP_014349726  395 RHFRGISMCLFLLVFPCYMAYKIFRFFHMDFWLLILVSSCILTSLQATGTIIIYLLFIVELLWSHPIESLDEIIYYVNAV 474 coelacanth
XP_032584257  549 GNSVEFCFGILLFINGAWILIFESaqnatGGAIRAIMMCIHAYFNIWCEARAGW 602
XP_002639063  513 NKGIELIAANVVLGFGCYQLVAVG-----FSLATFAILLFHVIVNIYKRAGQTF 561
Q5SWK7        458 YRLLEFVVALCVVAYGVSETIFGE-----WTVMGSMIIFIHSYYNVWLRAQLGW 506 house mouse
10_pfamImport 452 SRVLEFLVALCVVGYGTWESLFGE-----WSWMGASVIIIHSYFNVWLRAQSGW 500
XP_001342512  453 CRVLEFAVAVCVVAYGAWESLWGE-----WSWMGASVIIIHSYCNVWLRAQAGW 501
XP_004082860  455 SRVLEFLVALSVVAYGTWESLFGE-----WSWMGASVIIIHSYFNVWLRAQSGW 503
XP_008121044  454 SRVLEFLVALCVVAYGSWESIFGE-----WSWMGASVIIIHCYFNVWLRAQSGW 502
XP_015784398  469 TKVIEFIVASSVVFVGIFEGISNK-----WNWTNAFILIIHCYFNVMQRFQAGY 517
6_pfamImport  449 GNIIEFLFGVVMFGNGAYTMMFES-----GSKIRACMMCLHAYFNIYLQAKNGW 497
XP_014349726  475 SRVLEFLLALCVVTYGSWESLFGE-----WSWVGASVIIIHSYFNVWLRAQSGW 523 coelacanth
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