3HKZ,7OK0,4QJV,1XPP


Conserved Protein Domain Family
RNA_pol_L_2

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pfam13656: RNA_pol_L_2 (This model is not part of the current CDD release)
RNA polymerase Rpb3/Rpb11 dimerization domain
The two eukaryotic subunits Rpb3 and Rpb11 dimerize to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerization domain of the alpha subunit/Rpb3 is interrupted by an insert domain (pfam01000). Some of the alpha subunits also contain iron-sulphur binding domains (pfam00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.
Statistics
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PSSM-Id: 520845
Aligned: 227 rows
Threshold Bit Score: 38.6549
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3HKZ_L        13 LELEIEGEDHTLGNLIAGTLRRISGVSFASYYQPHPLS--DKIIVKILTDGSITPKDALLKAIENIRGMTSHYIDE 86  Saccharolobus solfa...
AGI85916       8 LRLGLKNHSTTIIEPLIQELNQNEDVEYCRYIVDHPDLddPYLEVRVRNG---TPEEALKKASAAVGEYFSSIse- 79 
Q9HIC5        21 ITVEMINYDNTLLRTLVEEILKDDQVDEARYYIKHPVIdnPQIYVRVKSG---KPQSAIKRAVRKLSKLYEDLGTQ 93  Thermoplasma acidop...
EQB64681      13 IVYEVLNNDNTILRPLMEEIENDSMVDNVRYYFEHPYLsnPKIHIKVKQG---KPQAALKRSLRRMEKIFENLHGQ 85 
WP_008083185  16 MILEVINADRTLLIPLVEELNKDEMVEQAIYHYDHPYLenPTLKIRVKSG---KPQAAIKRAAKRLEKVFEEMEKE 88  Candidatus Acidulip...
WP_015019986  13 IELKIREEDISILYIIQHELLKEKSVDFAGVIQKHPLT--KEYQMRVVT-KRKDPMEVIQDTSSSAQEYSKdvvsm 85  Candidatus Nitrosos...
ABK78042      13 ANLSIRESDIGILYIVQHELLKKSGIEFAGVILKHQLT--SEIWMRVNT-SSGSPVKAITDAADASVSTFGDLEKL 85 
1XPP_A        23 ITVEMINYDNTLLRTLVEEILKDDQVDEARYYIKHPVIdnPQIYVRVK---SGKPQSAIKRAVRKLSKLYEDLgtq 95  Thermoplasma acidop...
WP_012216139  13 INLSITETDIGILYLIQHELLKESNIDFAGVIVKHPLT--NECWMRINS-S-SKPLGEIKKATDSAIKMADEFKQL 84  Nitrosopumilus
Q6L204        16 ITVEMINYDNTLLRPLVEEISRDDSVDEIHYYIKHPNLdnPQIHVKVKSG---KPQSAIKKSIRRIDRIYNSLIDD 88  Picrophilus oshimae...
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