Conserved Protein Domain Family
FtsK_4TM
?
pfam13491: FtsK_4TM 
4TM region of DNA translocase FtsK/SpoIIIE
4TM_FtsK is the integral membrane domain of the FtsK DNA tranlocases. During sporulation in Bacillus subtilis, the SpoIIIE protein is believed to form a translocation pore at the leading edge of the nearly closed septum. The E. coli FtsK protein is homologous to SpoIIIE, and can free chromosomes trapped in vegetative septa.
Links
?
Statistics
?
PSSM-Id: 493438
Aligned: 43 rows
Threshold Bit Score: 73.4055
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q21TL6         23 RRFADEMGLLLGLLLLLLWLVALLTYSAQDAA-----------W-----STSGSG-APVLNRAGRLGAWLADGSY-YVFG 84   Rhodoferax fe...
2_pfamImport    1 VRHLAELGALCAVLAGLTVLVSLVSYHAGDPS-----------L-----DTASS--LPPQNLAGRFGAILADLLL-QGFG 61  
Q16E20         27 EKRGKELFGLVLMVLGAMACAMIASYTPDDPN-----------W-------MVSTdATVQNWMGRIGASIAAPLF-MIVG 87   Roseobacter d...
Q5LMZ6         22 ERRGKELLGLALIVLGLLAAAMVGTYTPDDPN-----------W-------MVSTdAPVQNWTGRIGASIAAPLF-MIVG 82   Ruegeria pome...
Q0AXI0         25 ERIKREILALVVFMLAIFVYISVSQFSGRAES---------------------------TQFIGVLGSYILKGLE-LLLG 76   Syntrophomona...
Q1MSA3         32 QKLARELFGLFLIFWGLLVLLSLLSHDQRDPS-----------L-----NHVVSNfSKAHNQAGIFGAYISGLLV-DIFG 94   Lawsonia intr...
WP_015751737    4 NKLIREFTALALVFCAALLGVSLATYSPMDPG-----------F-----NQRLSSgFTVHNQAGIVGAYLAGLLV-DLFG 66   Desulfohalobi...
WP_015774647    6 NKLVREICALVFACSLALVTLALYSYSPADPG-----------F-----NHQSVAgHKTQNLVGTLGAYVAGGLV-DLCG 68   Desulfomicrob...
WP_012499064   37 QRRKHEVIGLAIMFVSFLLLISIFSYSPEDNSkienisifdffS-----EYATLAaDQLKNPLGLIGAKLSGFIMeSILG 111  Chloroherpeto...
WP_012509026   16 KALQKEIGGLVLMLLALFLIAALLSFHPDDEAsfg-----tlaWhdifsRSARDVaESIHNPFGLFGARISAFFIrSFLG 90   Pelodictyon p...

Q21TL6         85 FSVWWCVAAAVRTWlaglARWLRGrdllggqaepatsS--NsliarlasSRTAFWCALALLLCASASLE----WS-YLYS 157  Rhodoferax fe...
2_pfamImport   62 VAGALPALVLLAWG----FVLVNR-------------GeiT--------RWRLRALAALLAMPCLASMFgvfhAL-NAAF 115 
Q16E20         88 WGSWGIGIVLVAWG----LRFALH-------------AgaE--------RALGRLIFAPIAIALGSIYA----AT-LTPA 137  Roseobacter d...
Q5LMZ6         83 GGAWGIPLVLIAWG----LRFALH-------------SgeD--------RAIGRLVFMPIWIAVVSVYA----AT-LVPG 132  Ruegeria pome...
Q0AXI0         77 SGAVFFSFYLLFWS----IDIGID-------------KkmW----------STRMWGASLLFLSCLLWL----SLyDIPG 125  Syntrophomona...
Q1MSA3         95 FSAIVWPAIFIAWG----AGCITT-------------WltI--------PWWRWLGFFILSFCLISFGA----AW-NFGI 144  Lawsonia intr...
WP_015751737   67 IGAAAAPVGAAWGA----LACFVK-------------Rl-R--------PRWWRWIGFGLIFLCLTGWA----AH-PWAR 115  Desulfohalobi...
WP_015774647   69 AAAWLWPVFFALAA----AMLFF--------------PsfR--------PHWLRWIGGIMLAILVPLWL----HF-AVLS 117  Desulfomicrob...
WP_012499064  112 YPTALLVGVAAFWG----WTLFRR-------------QkhE--------HAVSVTVYATLFAVQIAAMF----G-----A 157  Chloroherpeto...
WP_012509026   91 YSVILPLTAIFLWG----WLLLRA-------------KslK--------PAILFSLYSLAFSLDIATMF----GL-TSAP 140  Pelodictyon p...

Q21TL6        158 le----arLp-GNGGGILGYLVGPW----SVQWL--GSVGSA------LVAIALGVLGTARVFHFSWGQV---AERLG 215  Rhodoferax ferr...
2_pfamImport  116 apa---wpVa-AGPGGAIGALLGGYgavvAHSAL--GVIGRV------LLLGLSALIGIAV----SAFAF---GLTSG 174 
Q16E20        138 gnw--ldiHs-FGLGGLFGDTVMGA----ILTLLpvGSTVTV------KLMSLLMAIGIIVFGGFVLGFTraeVARIG 202  Roseobacter den...
Q5LMZ6        133 etw--ratHs-FGLGGLFGDTVMGA----LLTLV--PLGSHLmvkltsLAMAVVMLTMAAFVLGFTWPEI---RRGLR 198  Ruegeria pomeroyi
Q0AXI0        126 glsaweagIk-GMGGGVLGGILATG----VITLL--GKVGAA------IILILNIAVAVLLIVGKP-IKV---IIRFL 186  Syntrophomonas ...
Q1MSA3        145 --------Gd-VRGGGIIGMTIYKQ----SSIIF--GTIGST------LIWLFLFFISLEFAFGIAWLNI---LHRLQ 198  Lawsonia intrac...
WP_015751737  116 eh----vhLqaLQGGGLLGRLVHDT----AVSYL--RALGAG------LVLAFVGLVGLQLSLGLSWSTL---GKRFR 174  Desulfohalobium...
WP_015774647  118 ldl---seSg-MVSGGFVGRTLYAL----LQRVF--GNYGFV------LVAVCLTLIAGRLLFGMSYRAL---VEKCA 176  Desulfomicrobiu...
WP_012499064  158 tn----weIs-EAMSGAIGRLIATF----LRTII--GDFGTW------SILLILLFVTIVLMIDLDIQKT---LDRIT 215  Chloroherpeton ...
WP_012509026  141 --------Fs-DMMAGAIGRMLAEF----LSVVI--GFTAAL------VLLSVIALVLTLYMGQTALAEG---MRLVL 194  Pelodictyon pha...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap