Conserved Protein Domain Family
Lys_Orn_oxgnase
?
pfam13434: Lys_Orn_oxgnase (This model is not part of the current CDD release)
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase
This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).
Links
?
Statistics
?
PSSM-Id: 520733
Aligned: 28 rows
Threshold Bit Score: 426.624
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q89TA8       101 EMLDVIGIGIGPFNLSLAALIEPTP--LRALFLEKRDALVWHPGLALPNSRLQVSPLKDCVTLVDPTSPYSFLNYLALHG 178 Bradyrhizobium ...
P65199         4 EIYDFVAIGIGPFNLSLASLSAPLRg-VRTLFLDKKSGFDWHPGMLIETSTLQNPFLADLVSLADPRSEYSYLNYCKLTN 82  Bordetella pert...
5_pfamImport   1 KIYDFIAIGIGPFNLGLACLVQPIQe-INSLFIDQNPSFNWHPGMMLESSTMQTPFMADLVTLASPTHPLSFLNYIKKKG 79 
WP_011914714   3 KIYDFIGIGIGPFNLGLACLAQPIDg-LDCLFLDRAEGFNWHPGMMLDSATLQTPFMADLVTLADPTSRFSFLNYAKQIG 81  Stutzerimonas s...
WP_003956623  11 QPHDLVGIGIGPSNLSLAALAHGVPggLATAFFEQSPRFGWHPGLLIDGAVLQVPFLADLVTLADPASPWTFLNYLRGRE 90  Streptomyces cl...
Q9K9M5         5 QVLDVFGVGIGPFNLGLAALLDQTK--CKSLFFDLKSQFDWHPGMLLEGTTLQVPFLADLVTMVDPTSPYTYLNYLHEHR 82  Bacillus halodu...
4_pfamImport   1 HVLDLAGAGIGPFNLSLAAQLDSIPa-VTAQFFDSRPAFSWHPGMMLPGADMQTSFLKDLVTGTNPTSPWSFLSYLVRHK 79 
WP_012592293   5 QTLDLAGIGVGPFNLSLAAHLDSIPe-LDVRFFEQRDRLDWHPGLMLPNADLQTSFLKDLVTATHPTSPWSFLAYLVAQK 83  Methylocella si...
Q6MMQ3         5 KHYDLIGIGIGLFNLSLAALLSKTPd-VKFRFFDRKHRFDWHSEIMFADSEMQTSYMKDLVTAADPTNPFSFMNFLVQKG 83  Bdellovibrio ba...
Q3JA65         3 dVFDLVGIGIGPFNLSLAAISEKNKe-LKTHFFEQKPLFLWHSEIIFPDSDMQTAFLKDLVTGVDPTSPYSFLNYLVMNG 81  Nitrosococcus o...

Q89TA8       179 RLYSFVNKRNASTSRQEFIEYYRWVAGRLKT-LRFSEVVNDVIPFRDG----YRIST-------NTT---TYLARAVVVG 243 Bradyrhizobium ...
P65199        83 RIYSYYMRENHYLSRAEYTRYCQWVAARLPN-LRFGCDVQGVLHDPEShs--ylVTGqht-msgQRF---MFRCRKLVLG 155 Bordetella pert...
5_pfamImport  80 RIYSFYIRESFFLMRKEYNQYCQWAAEQLSN-LRFNTQVESITHDAAAs--lYTLHCldt-rtgEKH---QFSCKKLVLG 152
WP_011914714  82 RLYAFYIKEDFFLMRREYNQYCQWVVEQLDS-LRFGHFVQHVDYLDERr--cYRVRGvha-rsgEGF---EFLTRRLVLG 154 Stutzerimonas s...
WP_003956623  91 RLFPFYFAQTFHVHRSEYDAYCRWVSDSLPG-LHFGHRVDAVRWNPERa--lFEVDFtrfgpegEAQapgRTHARHIVLG 167 Streptomyces cl...
Q9K9M5        83 RLYHFYFYEKFHIPRTEYNHYCQWVAGQLPT-LQFGAEVENIEQSA-NgryvVTVFEre---qnRRS---TYEANHIVLG 154 Bacillus halodu...
4_pfamImport  80 RFYQFLNAEYEAVPRKEFADYLGWVARGLPS-LSFDQTVRQVDVADr----lLSIDV-------DGT---RVLARTMAVG 144
WP_012592293  84 RFLKFLNAEFEATPRREFANYLEWAANGLPN-LQFNTRVREISFDRSa----FKVRF-------DED---SCSAQHIALG 148 Methylocella si...
Q6MMQ3        84 LFYAFLNTGRQTITRREFEMYCQWVSQNLPEyLSFDSDIESVTYDGSkf--iLTIN---------GE---IFTAQNICIG 149 Bdellovibrio ba...
Q3JA65        82 FFHSFMNTKRHVITRREFEIYCQWVTRQMPEkLSFNSKIKNLYYDGEN----FIIEN-------QKE---RFKSKNICIG 147 Nitrosococcus o...

Q89TA8       244 VGVEPKIPACARsl---lCGTLYHAA-DYLER-PLPQAAEHVLVVGGGQSGAEITEDILTR--SV--S--TQITWSTSRS 312 Bradyrhizobium ...
P65199       156 LGSQPYLPACCDr----rAAPFIHSA-DYLRHkYELQGRASITIVGSGQSAAEVFHDLLREsgRH--D--YSLAWITRSP 226 Bordetella pert...
5_pfamImport 153 TGPSSYIPKCCRpf----sDQMVTSG-EYLKNkAALQQKKSITVMGSGQSAAEIFYDLLED--IDtyN--YQLNWVTRSP 223
WP_011914714 155 TGTTPYLPSCCEgl----aEHVSHSG-NYLQDkPRLQGKRSITVVGSGQSAAEIYYDLLQDidRH--D--YQLNWITRAP 225 Stutzerimonas s...
WP_003956623 168 VGTEPYVPDALRpltaapGAPVLHSA-DYLAHrDRLLAAGHITVVGSGQSGAEVFLDLLRHrpAG--A--EGIHWISRSE 242 Streptomyces cl...
Q9K9M5       155 VGTKPYVPADFRpi---lgERIFHSG-DYLNRkEEVLNAGSVTVIGSGQSAAEIFYDLLKG--QQeqG--YELSWFTRSK 226 Bacillus halodu...
4_pfamImport 145 IGKKPSLPDWAEgl---pKSMIFHSS-EATERl-GGIKARRVAVIGGGQSGAEIVDALLDL--KS--V--ASIQWISRRA 213
WP_012592293 149 IGLSPFLPAWADeq---igDDCFHSS-TTTRRlD-GMTGERIVVVGGGQSGAEIMLHLLSE--GR--HtpAEIRWVSRRP 219 Methylocella si...
Q6MMQ3       150 TGLVPHLPEFAQal---egPEVFHAKsSYLKLl--DATNKDVVVVGGGQTGLEIFRNCLQGkwGH--P--KSLKLIASRQ 220 Bdellovibrio ba...
Q3JA65       148 TGVSPKIPSFTVpy---igDTFFHAK-SESIKn-LDVSGKRIVIIGGGQTGVEVFRNALRRkwGN--A--KSLTLVSSRA 218 Nitrosococcus o...

Q89TA8       313 NFFAIDDNSFVNEAYTPAYSRRFHALPLQQRRDIVEGE-MLTSDGISVDLCNRLYEMLYE-R-SVDGt-lSD--R-FRVL 385 Bradyrhizobium ...
P65199       227 RFFQMENTKLTLELISPDYTEYFHDLPEARRQEILTQQn-SLYKGINASLINQIYDLLDE-K-VHDG---DN--R-YTLL 297 Bordetella pert...
5_pfamImport 224 RFFPLEYTKLTLEMTSPEYVDYFYDLPENKRDALNRTQkS-LYKGINSSLINEIFDLMYT-K-RLNG---EL--N-VGLY 294
WP_011914714 226 RFFPLEYTKLTLEMTSPEYIDYFHSLPRSTREKLIDSQkG-LYKGINGTLINAIYDELYN-Q-SLKG---EV--P-TQLL 296 Stutzerimonas s...
WP_003956623 243 SFAPMEYSKLGLEHFTPDYTHYFHSLPEQTRDRLIPRQwQL-HKGIDARTIAAVHEELYR-R-TLDG---GW--PqTVLT 314 Streptomyces cl...
Q9K9M5       227 GFYPMEYSKLGLEHFSPDYTRYFYQLPKEKKKAVLQKQ-DLLYKGISFQTIADIYDLLYE-R-TVGG---VK--PkVHLQ 298 Bacillus halodu...
4_pfamImport 214 NFEPLDATPFTNELFTPAYMDRFHGLAEDLRITHTRRQ-LLASDGVSPSTLKKLYRRLYE-R-QLETagrDD--G-MMLR 287
WP_012592293 220 NFEPLDATPFTNELFTPEYVDSFRRLGEDRRHALVASQk-LAADGASASTLRALYRRIYA-M-KYLE---DNdvD-IGLL 292 Methylocella si...
Q6MMQ3       221 NLEPLDNSPFVNEYFTPSYVKEFLQLDQDQKDPIVKYQk-LASDGNTPEYLETLYRDLYQ-LkHVWG---DK--RqIEIL 293 Bdellovibrio ba...
Q3JA65       219 NLEPLDESPFTNEYFSPHYVEDFFSINPQLKRNIVDYQk-LSSDGNTPTYLQSLYNDLYFiQ-NVEQ---SPi-D-FKIL 291 Nitrosococcus o...

Q89TA8       386 PSVVVKGITSHK--MGWRVDLDEIATQRNSCILVDRIVLATGFQP 428 Bradyrhizobium japonicum
P65199       298 TNSELRACRYDPlqERFQLDFQHLDCDRPFSHATDGLVLATGYSH 342 Bordetella pertussis Tohama I
5_pfamImport 295 TNSELQQIHQVTe-GKFVLDLFQQEQEAAFSLETEGVVLATGYQY 338
WP_011914714 297 TNAELRRCQRLAd-GTLELEFFQHELQQSYRHRCEALVMASGYQY 340 Stutzerimonas stutzeri
WP_003956623 315 PGVTVRTAGRLAt-TKVELHLEHAQQGTRSRLTTEAVVLATGYRE 358 Streptomyces clavuligerus
Q9K9M5       299 ALTELVSLEAAG--GAFDLLLHQTEQNKEKQVKSEVVILATGYRP 341 Bacillus halodurans
4_pfamImport 288 PHRDVIAAKRNG--ATIELTMRNGFDDAIETVEVDMIVAATGYRF 330
WP_012592293 293 PHRDVIEVDRQGk--EFKLVMRNGFDGGIEVITARTIILATGYTF 335 Methylocella silvestris
Q6MMQ3       294 PYRRVTEMVKIGd--RYKMHIHNGFSNQSETTTADTVVLSTGFRV 336 Bdellovibrio bacteriovorus
Q3JA65       292 PYRRIQGVESNGk--GYKLTISNNFSQKEESMEADIVILCTGFEn 334 Nitrosococcus oceani ATCC 19707
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap