Conserved Protein Domain Family
UCH_1

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pfam13423: UCH_1 (This model is not part of the current CDD release)
Ubiquitin carboxyl-terminal hydrolase
This is the ubiquitin carboxyl-terminal hydrolase domain found in a variety of proteins, including PAN2, one of the subunits of the poly(A)-specific nuclease (PAN) is a deadenylating enzyme involved in cytoplasmic mRNA turnover (consisting of PAN2 and PAN3), involved in the initial trimming of poly(A) tails.
Statistics
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PSSM-Id: 520726
Aligned: 193 rows
Threshold Bit Score: 62.664
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_019020389   109 VGMDNYsNTTCYLDSLIvalfysnssfdflldktidpnlssefqqqvermktvlrfi-----------vnllragehint 177 
Q6BZ78         514 SGLENH-LDNSYINSLL--------------------------------------------------------------- 529  Debaryomyces...
CCE81558       513 SGLENH-LDNSYVNPLI--------------------------------------------------------------- 528 
XP_004335984  1396 VGLKNL-GATCYMNSLM--------------------------------------------------------------- 1411
11_pfamImport    1 AGLRNL-GNTCFLNSII--------------------------------------------------------------- 16  
XP_018754164    38 VGAENRgNVTCYLDALLfsmfakidafecmlkndfpeednrnklvnllrmwvnmlrtgklvhtdmvscigaisvmlkltf 117 
KPM34673       133 VGAENRgNVTCYLDALLfamfskldafdcilkndfpeedsraklvtllrmwvnm-----------------lrtgklvht 195 
9_pfamImport     1 VGAENRsAVTCYIDALLfamfskldafecmlknqfpaddprnrlvtllriwvnm-----------------lrtgrlirt 63  
XP_031886882   122 VGAENRgNVTCYLDSLLfamfakldafecmlkndftdeprrrlvtllrlwvnm------------------lrsgemihv 183 
ERT01796       127 VGAENReFVTCYLDALLfamyakleafdcmlkneelnenqrnlaallrlwvnm------------------lrtgklirt 188 
XP_019020389   178 nimyqllvtldslgcdialsrkqqdalQIFEFLaeslslPLLTl-KLDIIHTgklnVNDD-------------LRLIGER 243 
Q6BZ78         530 ---------------------------QLYKYS------PVFQ--NFIIKHLlk-eWLPNdlttiiqngnpqgSSILNEL 573  Debaryomyces...
CCE81558       529 ---------------------------QIYKYC------SIFQ--NFVIKQSlk-eWLPTdldtvinkgnesgSSLVTEL 572 
XP_004335984  1412 ---------------------------QQFFMI------PGFR---WGMLEVqdseEKKE-------------ESLLWQL 1442
11_pfamImport   17 ---------------------------QCFTHT------VPLVqgLLSLKHEasshGAGE-------------FCVLCAV 50  
XP_018754164   118 eqtkliqdaladcgwsdarmleqqdtsEAFAFItetlqlPLLSl-QVDLFHQgk-kDKDD-------------HKVVYER 182 
KPM34673       196 dltkliqdaladsgwsdarmleqqdtsEAFAFItetlqlPLLSl-QVDLFHQgk-rDKDD-------------HKVVYER 260 
9_pfamImport    64 dltkliqdtmaecgwldarlleqqdtsEAFAFLteklelPLLSl-QVDLFHQgr-hDDDD-------------HKVVYER 128 
XP_031886882   184 dmtkliqdaladcgwsdaklleqqdtsEAFAFItetlqlPLLQl-QVDLFHQgk-nDKDD-------------HKLVYER 248 
ERT01796       189 dmtetiqnalascgwqdasileqqdtsEAFAFItetlqlPLLTl-QVDLFHQge-rDADD-------------HKVVYER 253 
XP_019020389   244 SLLIsissSATSNDSp-iTLeECLNTYFNNSITvrrhi--------------dqqlgSTSgnkirfhnsdaicssgEsla 308 
Q6BZ78         574 GYIF----DMMNKSH---GK-NCKTSNFSNVLS------------------------QNQ----------------V--- 602  Debaryomyces...
CCE81558       573 GYLF----DMMDKSV---GK-NCIITNFSKVLS------------------------TKQ----------------E--- 601 
XP_004335984  1443 QTIF----GYLQESE---KK-YYDTRPFCSSYK------------------------DWE-------------------- 1470
11_pfamImport   51 R-------EQIEHSLgysGK-VVSPSNLVDNMS------------------------QIS-------------------- 78  
XP_018754164   183 LLNLavppDPEEKGL---KLeDCLEEYFNAQVDvkrdsedgkklgveeksrsetptlKHR-------------------- 239 
KPM34673       261 LLNLavppDPEDKGI---KLeDCLEEYFNAQVDvqrdseeakksslremsrgevprlVHR-------------------- 317 
9_pfamImport   129 LLNLavpsDTDGNGI---KLeDCLEEYFNTQVDvlrdseeakksiaedgspgavptlSIP-------------------- 185 
XP_031886882   249 LLNLavppDPDGKGI---RLeDCLEEYFNTQVDvlrdshee--------kkelaqstPNK-------------------- 297 
ERT01796       254 LLNLavppDPENKGV---QLeDCLEDYFNTRVDvlrdraedk-------kgaekatlEPS-------------------- 303 
XP_019020389   309 qnkdeiNeyEKLGILtSSSssKTsvpipssistsltpsisafwpntlqtplpssdasisapdqlpitpqqssqdssvspt 388 
Q6BZ78         603 ------A--QMQEL-------INkdd------------------------------------------------------ 613  Debaryomyces...
CCE81558       602 ------A--NRQGL-------INede------------------------------------------------------ 612 
XP_004335984  1471 ------G--QPMNVGqQQDadE---------------------------------------------------------- 1484
11_pfamImport   79 ---------SIFQRHqQEDahE---------------------------------------------------------- 91  
XP_018754164   240 ---------DTIRIItEERgeASt-------------------------------------------------------- 254 
KPM34673       318 ---------DTIRLItEELgePStpt------------------------------------------------------ 334 
9_pfamImport   186 ---------NQIRLIrDEEsvST--------------------------------------------------------- 199 
XP_031886882   298 ---------NTIRLVtPEGstDFe-------------------------------------------------------- 312 
ERT01796       304 ---------ETIRLVpQESpaDTsadapakangpvgtvetveavgvveandeagtaneitssegsks---thgsfstadt 371 
XP_019020389   389 gsqltstksiltrtpsssksrsdfetptgsqskkSLPNTGSSITdlspdnnnl--------------------------- 441 
Q6BZ78         614 -------------------------------cknLNAFEIRAII------------------------------------ 626  Debaryomyces...
CCE81558       613 -------------------------------cksLNAFDLRDII------------------------------------ 625 
XP_004335984       --------------------------------------------------------------------------------     
11_pfamImport      --------------------------------------------------------------------------------     
XP_018754164   255 ---------------------------------pTSPLVNTPLEitptsekggsllladpnvkngn-------------- 287 
KPM34673       335 --------------------------------vtASPIAISPLQqpsideqaaplpnqdskpedgkapveplveapseal 382 
9_pfamImport   200 ----------------------------------PTAISSSPIDmspltpradpllekdedkeetslseqvngtsqndvp 245 
XP_031886882   313 ---------------------------------aADVLSSSPLQlspalerrwtasqap--------------------- 338 
ERT01796       372 tttgvvtatttaettenatattarletsglalapAGAVTASPITmspkgdptneafdrdpapvvrrwtmae--------- 442 
XP_019020389   442 ----------------------------------------tatdsatlDsvNligSFRNVTEKLERQRtrS--------- 472 
Q6BZ78         627 ------------------------------------------------G--K---FNKFLLSTCNNDLlnQfn------- 646  Debaryomyces...
CCE81558       626 ------------------------------------------------I--K---LNRYLLDCCDSELreQys------- 645 
XP_004335984  1485 -------------------------------------------------------FMNMLLDRLESILkkTqe------- 1502
11_pfamImport   92 -------------------------------------------------------FLQCLLDKLDSNWskYeanandsss 116 
XP_018754164   288 --------------------------tpddeeegevttveivqnkpsmRarStsvIQRVVLDEDGHPSt----------- 330 
KPM34673       383 veapveanaeanveanvkvnieapneeqngksvdsepapvvpqnkpavRarStsvIQRLILDEQGRPSs----------- 451 
9_pfamImport   246 tet------pqspsapidtpqspsvlsagdsagnasdraagsssrmtiRhrSasvIQRVMLDNGGRPTs----------- 308 
XP_031886882   339 ---------------------------------ngvpespsgssrptpRhrStsvIQRVVLEEKEKPe------------ 373 
ERT01796       443 ----------------------pntdasenpaesssaagrrpsalsgpRqrSasiIQRIVIED-GKPSepQ--------- 490 
XP_019020389   473 ---STLASVLnnvqsinP--------------KKlTRRSSSISNTEvslPaWMYLqllpyytdpevkltvenheeyyrrr 535 
Q6BZ78         647 --tS-LSEIT-------NigyeieiksngcniNN-VNYNSQLTVd-------lMSppi---------------------- 686  Debaryomyces...
CCE81558       646 --tS-LDNIM-------RcvysietrsngcgiAD-RSYASSLYId-------lTEv------------------------ 683 
XP_004335984  1503 --eKLLSQFF-------GgalsnqiiskdcthVS-EREENFFTLsldik------------------------------- 1541
11_pfamImport  117 lddTLVRQIF-------GgrlvsqvrccncghNS-DTYEPLIDLsleie------------------------------- 157 
XP_018754164   331 --pDNFT-ML----------------------QKaMRKGSTVV-KAvtiPaWQFFrlipwh-----------------al 367 
KPM34673       452 --pNSPT-ML----------------------QKaMRKGSTVV-KAvtiPaWQFFrlipwh-----------------al 488 
9_pfamImport   309 --sETST-LR----------------------KRlSGKGSTVV-KAvtiPaWQFFrlipwh-----------------av 345 
XP_031886882   374 --sDTPS-ML----------------------EKaRRTSSTVV-KAvtiPaWQFFrlipwh-----------------aa 410 
ERT01796       491 ---EAST-LL----------------------QQfKKQGSTIM-KAvtiPaWQFFrlipwh-----------------st 526 
XP_019020389   536 isrsKTIdsaqnipvglqdktssddlfHTDaeSYFGRRFANR-------RPMVPIClKRYIWNERGQSVKiqrkvtipei 608 
Q6BZ78         687 -nklSILisanst--------satkknLNI--LNYLDYSMNQfkt--ikCQQCNN--SFPHLLEIRQSLV---------- 741  Debaryomyces...
CCE81558       684 ----PYNraii------------nglnRSLtiVDSIEHSMQQskt--ipCQYCDK--NYKHFLEIRRTLV---------- 733 
XP_004335984  1542 ---------------------------nkksiLESLALYVEGdmlegdnKFHCSEC-NAKVDALKRCCVK---------- 1583
11_pfamImport  158 ---------------------------dvdslESALNSFTKVesiedteKFTCESC-KEQVKVEKQLMLE---------- 199 
XP_018754164   368 ssgePRN-------------------------NTEVALNFEQ-------RPVVGIClKRYAMTESGQPKRhntfidipds 415 
KPM34673       489 tsnePRS-------------------------NVDVASTFDQ-------RPVVGIClKRYAMTESGQPKRhntfidipds 536 
9_pfamImport   346 nstePRN-------------------------DVEVAMNFDQ-------RPVVGIClKRYAMTESGQPKRlntyidipes 393 
XP_031886882   411 gnkePKN-------------------------DMEVAMNFSQ-------RPVVGIClKRYMMTNSGIPQRqntfidipds 458 
ERT01796       527 snsePQS-------------------------DVEVMRQFNK-------RPVVGIClKRYLMNEHGQFLRhntyidipds 574 
XP_019020389   609 iKYPYFIAEDKK---------------KpGYIDfrRSYDH------------------QAPRGSFMLVLQSCVCHRGNS- 654 
Q6BZ78         742 -HLPPVISINVNftgqef----nliqnFpNWLV--PEFYTygmnnk------vsfklhSNDNLSNKYELLGYVCEINVGs 808  Debaryomyces...
CCE81558       734 -KCPPILSININlsaqdt----kfikeHnGWLS--KEFFLlsengr-------sfistREENGFNKYELLGYVCEINHGs 799 
XP_004335984  1584 -NLPDNLIVHLKrfefdletmkriklnDsCQFPmiLDMEPytkeglakkegtsledlpQRDESYYKYELAGILVHTGTA- 1661
11_pfamImport  200 -QAPSVATLHLKrfksdgif--vekvdkkVEFPleLNLAPytk-------------gsNNESGDLKYELFAVVVHVGVS- 262 
XP_018754164   416 lRLPHFMLADEPkae-----------edmNVLN--TDYKL---------------------------VLQSVICHRGDS- 454 
KPM34673       537 lRLPHFMMADDPkie-----------edpNPLN--SEYKL---------------------------VLQSVICHRGDS- 575 
9_pfamImport   394 mRLPHFMLADGPnie-----------eeiNGLA--TEYKL---------------------------VLQSIVCHRGDS- 432 
XP_031886882   459 lRLPHFMLAGETqle-----------edpNGFS--MEYKL---------------------------VLQSVVCHRGDS- 497 
ERT01796       575 lRLPYFMMGEDGqqp------------dgNALS--NGYKL---------------------------VLQSVVCHRGVS- 612 
XP_019020389   655 T---NSGHYVSLVR---Krrfd-------vyhMdannEWLLFNDIEI 688 
Q6BZ78         809 EflkGKHNLVSYIKi-----------------Es---KWYLFNDFLV 835  Debaryomyces hansenii CBS767
CCE81558       800 ElarGAHSLVTYIKie--------------------dKWLLFNDFLV 826 
XP_004335984  1662 D----YGHYYSFIR---Erlp---------kvAgeacKWYQFNDTLV 1692
11_pfamImport  263 S---TSGHYFCYIR------------------Tdp-dKWYRFDDSQV 287 
XP_018754164   455 L---QSGHYVSFARvapKllkdnrrhnfdpppDyeeaQWVKFDDLQI 498 
KPM34673       576 L---QSGHYIAFSRvapKlltnnrrhdfdpppDyeeaQWVRFDDLQI 619 
9_pfamImport   433 L---QSGHYISFARvapKlltdnrrhdfdpppDyeeaQWVKFDDLDI 476 
XP_031886882   498 L---YSGHYISFARvapKlltdnrrhdldpppDyeeaQWVKFDDLNI 541 
ERT01796       613 L---HSGHYISFARvnpKlltdnrrhdfdpppDyeeqQWVKFDDLDV 656 
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