Conserved Protein Domain Family
Peptidase_M60

?
pfam13402: Peptidase_M60 (This model is not part of the current CDD release)
Peptidase M60, enhancin and enhancin-like
This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonisation of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.
Statistics
?
PSSM-Id: 520711
Aligned: 21 rows
Threshold Bit Score: 218.818
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
WP_306701729    196 GKVNGVF-VGGVSKNSDWKRMLENSPTEVVDIVGNRVHLVY-PVEELKQFCPDK-GEELIALYDRIIGMEQRIMGLYKYR 272  Akkermansia...
Q5E705         1197 SAIAAPMfMMTSATEGSWITTPEESDAPITEIVGKRFSYTT-TTAGIKGHSEVD-VLEMTKQFDLFTIGVNEFYGRDGVS 1274 Aliivibrio ...
WP_306701441    356 GAVPSPLfVMGKTTPEQWAEQLENTKAPWGEIRMPRLIVTM-PVEQLKQCPE---VQKTAEFLQKNMALQDWIMGWDTKP 431  Akkermansia...
A4IG42          630 NAVQAPYfKSGETSVADWVSHIRQAPAPWAELEFENLIMTF-DSAFIRNLDR---PDEVAKLWDTIMRTITDLAARP--- 702  zebrafish
Q6QR59          624 GAVSAPYfRLGKTTQEEWKNLITHSKAPWGELATDNIILTI-PTVNLKELQD---PYPLLQLWDKMVRAVAKLAARP--- 696  house mouse
Q9Y4C2          633 GAVHAPYyKLGETTLEEWKRRIQENPGPWGELATDNIILTV-PTANLRTLEN---PEPLLRLWDEVMQAVARLGAEP--- 705  human
A6NFQ2          633 GAVPAPYyKLGKTSLEEWKRQMQENLAPWGELATDNIILTV-PTTNLQALKD---PEPVLRLWDEMMQAVARLAAEP--- 705  human
WP_022052472    201 GKVNGYFdAETQT-NEDWNKLLDQAVSPVMDVKTRYMQLAY-PVEFLKKFDYGK-GKELAQAYDQIMTQQYEFCGALKYN 277  Phocaeicola...
Q2U0W8          367 TAEPFPLfREGSTTDAQWKSMLDVTKVPFAEHDGKRVIITGlAKHAKKYADNGQrQQELLDTYAHIIAIQDRFSALKYNA 446  Aspergillus...
jgi:Bfae_09730  165 AAEPMATfVRGTTAEAEFQAQLDRSSAPFAELVSTHAIVTV-ERDRLLLFRHED-HEKLLGILDRVVEIEQETAGYTTEG 242 
WP_306701729    273 Mlp-------kNRMFGRVIWN---------------GFMHADGT--GAAFh--NGTMKEVGNPDKIpg-saWGIAHEFGH 325  Akkermansia...
Q5E705         1275 GahkmftdsapELEYQNMRLVddiq--------isiGSAHSGYPvmSTSF---PRQKSSLFKATDN-----WMLGHEIGH 1338 Aliivibrio ...
WP_306701441    432 -----------DRLHHPMRFVvdrq--------isaGAGHSGYP--AMAT----KDWTNSIAAGSIihsgsWGLWHELGH 486  Akkermansia...
A4IG42          703 -----------PKLPRKERFVadvq--------isyGFMHAGYP--IMMH---SGSAPGLVNVEEAykcglWGAIHELGH 758  zebrafish
Q6QR59          697 -----------FPFQRAERVVldkq--------isfGFLHSGYP--IMGL---ISIVEGIISEFKIrshgiWGVIHELGH 752  house mouse
Q9Y4C2          706 -----------FPLRLPQRIVadvq--------isvGWMHAGYP--IMCH---LESVQELINEKLIrtkglWGPVHELGR 761  human
A6NFQ2          706 -----------FPFRRPERIVadvq--------isaGWMHSGYP--IMCH---LESVKEIINEMDMrsrgvWGPIHELGH 761  human
WP_022052472    278 Rvp-------eKRILARVNFN---------------YFMFRDGD--GVAFlgnESTMKSALGPDIYk---dWGVNHEIGH 330  Phocaeicola...
Q2U0W8          447 Rdp-------rDRPSL-LRPMvves--------vnsGVATATNY--RAAIp--NRLSDQIYWVPRLrn--sWMVFHELGH 504  Aspergillus...
jgi:Bfae_09730  243 Gve-------sRPPSGPHHLVgypdgiegvgayatnG---------YTAYp--PPIQSTLLTVSGLtl-dgWGPYHELGH 303 
WP_306701729    326 VNQvrPAMKWVS-TGEVTNNIYSAYVNYMLNPSS-MRLEHERINGGDGN-MIGGRFNAYLNNgilkgenwlvqsgpdkrs 402  Akkermansia...
Q5E705         1339 NQA--ANWLNVVgAGETANNVLALYTQERNTGDMpRIKVSITNATEWANgDHPWADGTNADR------------------ 1398 Aliivibrio ...
WP_306701441    487 NHQs-PPFTMEG-QTEVSVNIFSMVCEVMGTGKD--------FESCWGGgMGPYGMSAEMKKyfsgtqty---------- 546  Akkermansia...
A4IG42          759 NQQr-GVWEFPPhTTECTCNLWSLYVHEQVFGI---------KSANAHPaITPADRQARTKMyfdggkdl---------- 818  zebrafish
Q6QR59          753 NHQk-SGWTFPPhTTEALCNLWTIYVHETVLNI---------PREQAHPsLNPELRRQRIKYhlnkgapl---------- 812  house mouse
Q9Y4C2          762 NQQr-QEWEFPPhTTEATCNLWCVYVHETVLGI---------PRSRANIaLWPPVREKRVRIylskgpnv---------- 821  human
A6NFQ2          762 NQQr-HGWEFPPhTTEATCNLWSVYVHETVLGI---------PRAQAHEaLSPPERERRIKAhlgkgapl---------- 821  human
WP_022052472    331 VMQmsPQLTWGG-MTEVSNNLFTMYVATLAGQPSrLSKSK--------------NYDKAFKEvleaekkpfi-------- 387  Phocaeicola...
Q2U0W8          505 QRQitRTWSWRA-MTEVTVNIYSLANLREYKP----------------PgHKNVAEWDNAKQyltkaskekd-------- 559  Aspergillus...
jgi:Bfae_09730  304 HHQqeP--VNPGdVVEVTVNIFSLAVQREF-----EREYGQVPRMREVDpETGTSHWDTAMEaleagirdy--------- 367 
WP_306701729    403 ggdnrpmvhdhfvkLAPLWQLELYFkva--------------------------gkgNPDFYPDIFYKAIKMDTRGKKDG 456  Akkermansia...
Q5E705         1399 --------------LNFFGQLKLWAednfdiaqweseaklaeersiynkneagqydqGWNFYKYLHRAARMPETFTEGLN 1464 Aliivibrio ...
WP_306701441    547 ------neapnkvqLFFWVELMYHL--------------------------------GFDAFRQVALQFHDKPYDNGELS 588  Akkermansia...
A4IG42          819 ------nswcmwmaLETYMQLQEKF--------------------------------GWDAFKKVFSLYHDMTGVPNDNA 860  zebrafish
Q6QR59          813 ------snwimwtaLETYLQLQEGF--------------------------------GWEPFIQVFADYRTLSGLPQNNE 854  house mouse
Q9Y4C2          822 ------knwnawtaLETYLQLQEAF--------------------------------GWEPFIRLFTEYRNQTNLPTENV 863  human
A6NFQ2          822 ------cdwnvwtaLETYLQLQEAF--------------------------------GWEPFTQLFAEYQTLSHLPKDNT 863  human
WP_022052472    388 -----mcvgdpfqkLVPFWQLYLYAke----------------------------kgYNDFYADLMEYMRNHPHKGTGNA 434  Phocaeicola...
Q2U0W8          560 -----fdsagfylsLVMFEQLRVVF--------------------------------GDGFYHELHRDARHTLVVD---K 599  Aspergillus...
jgi:Bfae_09730  368 ------aelgpfeqLAPFDQLRLQY--------------------------------GDEFAPAWATLVRQQEPLTEED- 408 
WP_306701729    457 E-----------------LQLAFMKNACDAARQDLTDFFRKTG 482  Akkermansia muciniphila
Q5E705         1465 KgdvnycssefaqvnslsKQDMMMICSSFLTGKDIETFFIKWK 1507 Aliivibrio fischeri ES114
WP_306701441    589 De---------------kKWEWVMNAFSRVTGKNMGPFFKVWR 616  Akkermansia muciniphila
A4IG42          861 G-----------------KMNLYAQTFSKVVNLNLSPFFKAWG 886  zebrafish
Q6QR59          855 D-----------------KMNLWVKKFSEAVHKNLAPFFEAWG 880  house mouse
Q9Y4C2          864 D-----------------KMNLWVKMFSHQVQKNLAPFFEAWA 889  human
A6NFQ2          864 G-----------------RMNLWVKKFSEKVKKNLVPFFEAWG 889  human
WP_022052472    435 Si---------------hNMYEFAKVSCDLLKTDLTDFFQAWG 462  Phocaeicola plebeius
Q2U0W8          600 Da---------------dKKHHFMTKAAQLTGQDLTEYFTKWG 627  Aspergillus oryzae
jgi:Bfae_09730  409 ------------------RWQNVIYSTSAAAGDDLADFWQAWG 433 
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap