Conserved Protein Domain Family
OmdA

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pfam13376: OmdA (This model is not part of the current CDD release)
Bacteriocin-protection, YdeI or OmpD-Associated
This is a family of archaeal and bacterial proteins predicted to be periplasmic. YdeI is important for resistance to polymyxin B in broth and for bacterial survival in mice upon oral, but not intraperitoneal inoculation, suggesting a role for YdeI in the gastrointestinal tract of mice. Production of the ydeI gene is regulated by the Rcs (regulator of capsule synthesis) phospho-relay system pathway independently of RcsA, and additionally transcription of the protein is regulated by the stationary-phase sigma factor, RpoS (sigma-S). YdeI confers protection against cationic AMPs (Antimicrobial peptides) or bacteriocins in conjunction with the general porin Omp, thus justifying its name of OmdA, for OmpD-Associated protein.
Statistics
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PSSM-Id: 520698
Aligned: 252 rows
Threshold Bit Score: 32.8449
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_025410380  133 ELAVPDDLAAALtqRKhaKARAAFDAFSPSHRREYVEWI-TEAKTDATRQKRLEQTLAQL 191 Gemmatirosa kalamazoonensis
WP_012163668  113 pFDIAEDIIAAI--QAepKALTHFKTFPDLYIRVRIGYIeEMRKRPENFDKRLKNFISKT 170 Acaryochloris marina
WP_012954829  113 DFIIDSDILDEL--KKdnETWNNFKNFPDLYKRIRIANI-QKEKDREAFDKKLANFIKDT 169 Methanobrevibacter ruminantium
CDF21606      116 gFKIDMDILHEL--QSdpIVWKNFCNFPDLYKRVRIDTIqIKRRDKELFRKRLDKFIENT 173
CCZ98051      116 gFVADEDILRAL--RAdpVVWEHFCGLPELYRRVRIDTIrIKRKEPELFRRRLEKFVECT 173
CDC97836      114 GFTIDPDILREL--QAdpVLWENFRRLPELYRRVRIDTIqIKRNQPELFRKRLDKFLENT 171
4_pfamImport    1 AFRIDPYILQLL--QQdpLIYANFLAFPRLYRHVRLDTIqIKKNQPELFRKRLEKFLENT 58 
Q5WD80        112 SFTIDKDIESRL--KEeeQLYQNFIHFPELYRRIRIDTIqSYRNEPDTFNKRLKKFIEHT 169 Bacillus clausii KSM-K16
WP_012065000  115 TFIIDEVIEKRL--KEdeQTHSNFMKFPELYRKIRIDTIqQVKHQPELYIKRLDKFIENT 172 Alkaliphilus metalliredigens
14_pfamImport   1 PFKIDSVIEEKL--KEdqQIYENFMAFPDLYRRIRIDTIqTNKKDAVLFESRLAKLIEQT 58 
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