Conserved Protein Domain Family
BrxL_ATPase
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pfam13337: BrxL_ATPase (This model is not part of the current CDD release)
Lon-like protease BrxL-like, ATPase domain
This entry represents the ATPase domain found in BREX system Lon protease-like protein BrxL from Bacillus cereus and similar proteins. BrxL is part of a type 1 BREX system which contains a C-terminal Lon-like protease domain (pfam05362. BREX systems (bacteriophage exclusion) provide immunity against bacteriophage, a system that allows phage adsorption but prevents phage DNA replication, without degradation of the phage DNA. Methylation of bacterial DNA by PglX probably guides self/non-self discrimination. This entry also includes a few uncharacterised viral sequences.
Links
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Statistics
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PSSM-Id: 520676
Aligned: 46 rows
Threshold Bit Score: 399.586
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_015261294   155 FTLLDYKNFCPYE-VNLDAFREARTHFEVEEWMGIILGAIDYNPDG--FeregwidTDiwNAKHTMLTRLLPFIQPRINL 231 Desulfitobact...
jgi:Kcr_0570   170 VLMVEFYPYEISS-FDIEYFRGARPHFTDEEWMDILIQSLGLNPSS--Y-------DF--EQKILYLMRLVPLIECNVNM 237
WP_011753460   150 VVLHDYRPFQASY-VDLKLFVESRSKFTFEEWVDLLVTSIGLNPKA--Y-------TL--GQRLLLLSRLIPVAEPNVNI 217 Thermofilum p...
WP_012186111   154 VIVTDFTPFQAPT-SDPKILAEARGYFTFEEWLDVLINTIGYNHNA--Y-------PGi-RRKLVLLSRLLPLVEENLHI 222 Caldivirga ma...
jgi:Cyast_2594 163 VSVIDFAPFQCSA-VDLKSYGELRSQFSTEKWRDLMFCSMGFNPEHpdY-------NH--QAKTWILSRLLPLVEPNFHL 232
WP_234397974   154 ISVMDFKPFKPYE-VDLDYFKEGRKEFTLEEWIDVLIRAMEYMPTG--F-------ESa-QQKLLFLSRLLVFVEPRLNM 222 Coprothermoba...
jgi:Anamo_1578 162 IYMISFKPFKPYK-VDVNYYQEVRKEFTLSEWIDMLLLAVDYNPAG--F-------LDt-RQKLALLSRLLPFVENRINL 230
CCY54304       168 IKLVSFKTFCPYQ-IDLEYYKEARNEFTIDEWIDVLLGAVDYNAAG--Y-------GNdeEKKLTMLTRLLPFIEKRLNL 237
WP_022459609   150 IEMSKYKPFRPLErLDLNSFRECRKKFTTDEWIDVLISAMEYTPSA--F-------SGk-TQKLEFLTRLLPFIEPRLNL 219 Bacteroidales
CCZ11708       154 VRMVDFKPFKPYSsVDIEYLREARQHFTNEEWFDVLLSAMEYDPDG--F-------TSm-TQKMEFLTRLLIFIEPRLNV 223

WP_015261294   232 IELAPQQTGKSYIFGKVGKYGWLLSGGSVSRTMLFLDRRagARAKGLVTFNDFVAIDEVKSISFTNDkEMGGILKGYMED 311 Desulfitobact...
jgi:Kcr_0570   238 MEFGPRASGKSYLYKNISHMVRVISGGRASPSELFYNKL--TKTIGLIGLMDAVVFDEINYLSLSGTeEMIGKLKDYMES 315
WP_011753460   218 LELGPRATGKTSLYRNVAYYSRIYAGGTITPARLFFDAR--LSVPGDLALHDVIVFDEISRVRLSNPdELVAKLKDYMVD 295 Thermofilum p...
WP_012186111   223 VEFGPKATGKTYVFRNVSRYTRIIVGGMISPAALFYNLR--NGMPGEIAIRDSVVFDEISKVRFPNPdEIVAKLKDFMES 300 Caldivirga ma...
jgi:Cyast_2594 233 IELAPKGTGKSFFYENINNKVSVVSGGKITPARLFIDGK--TREVGLLGRYNVVVLDEVQSLTFDNPdEIIGPLKTYLAN 310
WP_234397974   223 IELAPKGTGKSYIFNNLTKYGWCISGGTVTRAKMFYDIS--RRSFGYITRYDFVALDEIETLKFAEEeELKGALKNYLEL 300 Coprothermoba...
jgi:Anamo_1578 231 IELAPKGTGKSYMMSQLSKYGWLVSGGSITRARLFYDIS--RSTPGLLSRYDYVAFDEVQTISFPDVdEIRGALKGYMES 308
CCY54304       238 IELAPKGTGKSYLFGRVSRFGWLSNGGVMSRAKMFYDQN--RKSEGLVAGNDFITLDEVQTISFTDVdEMRAALKGYLES 315
WP_022459609   220 IELAPKGTGKSYVFGNLSKFVWLIGGGKVSRAKLFYDKS--RKTPGIMLHHDLVALDEIQSITFTDTmEMRSILKNYLEY 297 Bacteroidales
CCZ11708       224 IELAPKGTGKSYVFGNLSKYGWLVSGGKVTRAKLFYDKQ--KQQNGIIKNHDFTVFDEIQTIIFQEPaEIQAALKSYLES 301

WP_015261294   312 GYTTVGG-TRVDGDAGIIFLGNIAVEDMDAS----KDMLRELPDIFRDSALIQRIHGFVPGQFIPPL--SPRMYISGWAL 384 Desulfitobact...
jgi:Kcr_0570   316 GNYERGG-KLVSSDCSLVFIGNVESIPSs-----pRDIDSFLPEFARDTALMDRIHGILPGWKLPKIrsSQEHIARGKGL 389
WP_011753460   296 GFFERGAlKRAHSTCSLVFLGNVDVERIADP----SHILEYLPSFMRDSAFLDRIHGFIPGWRLPKImrSEESLASGYGL 371 Thermofilum p...
WP_012186111   301 SQYERGK-QRVASGSSIVMLGNVEVEEREGAyvpvEDLTYILPKPMRDSALIDRVRGLIPGWELPKIgmVKYHLSQGYGI 379 Caldivirga ma...
jgi:Cyast_2594 311 GSYNRGGySDIASDCSLVLLANIELNEYQRPkn-eYNLMANLPKFFSETAFLDRFAGILPGWEIPKF--QKEMMANQIGL 387
WP_234397974   301 GKFTIAD-VTKTSEAGFMLLGNIPLTSEHKPi--nDIYFSHLPDFFRDSALLDRFHGFIEGWHLPRI--NEDMKVSGYTL 375 Coprothermoba...
jgi:Anamo_1578 309 GEYRVGD-YRGTGKAGLVLMGNISDEKMRED----TDVFTELPYAFQESALIDRFHGFIKGWDIPRM--RENMKAHGWAL 381
CCY54304       316 GIFTVGN-YEGIADAGMILCGNIKKETMDADg--yANMFVELPTVFHESALIERFHGFIKGWNIPRM--NDDLKISGWAL 390
WP_022459609   298 GKTNVDN-YEFMSECGLILLGNIPLSEDGFPm--sDNYVEELPEAFKESALLDRFHGFIEGWLLPRI--TNDMALCDWTL 372 Bacteroidales
CCZ11708       302 GKTTIDN-NEFTSECGLMLMGNIPLSANRLPi--sPNYFDSLPNNFKESALLDRFHSFIEGWKLPRV--NDSMIFNGWTI 376

WP_015261294   385 NTEYFTEIMHLLRsPAEtmrYRGFVEELVDVSsKSGDTsgREQDAIMRLCTAYLKLFFPHadsalirDSKfKREFDKYCL 464 Desulfitobact...
jgi:Kcr_0570   390 SLDLISYWLHEMR-KFD---ASTIARSFMKF--GNVSI--RDERALIRLVSGAIKLIYPD-------LKVrDRETMERIV 454
WP_011753460   372 ASDYLAEVLHRLR-DVA---AESVVADHVEFV-GKYTI--RDEKAVKRLLSGAVKILFPN-------FEF-DNAELARVA 436 Thermofilum p...
WP_012186111   380 ALDYFSEALHTMR-KET---LVGEVSKHIELM-GEVTI--RDEKAIKKMLSAFIKLLFPN-------LEF-DKRELDIVT 444 Caldivirga ma...
jgi:Cyast_2594 388 KMDFFGEVLFALRrDTR---FQQYAETHTNFL-SKVSI--RHQQGIIKTASGFLKILYPH-------LDLtLQDYWNDCL 454
WP_234397974   376 NVEFFSEILHKLReRSE---YAAIVDELLDIP-PKADT--RDVTAVKRLCTAYLKILFPHit---dtSQItKEEFETYCL 446 Coprothermoba...
jgi:Anamo_1578 382 NVEYFSEVMHSLRnEII---YPAIVENLLMVP-KSSDT--RDVTAIRRICSGFMRLFFPHak---saEDVnIDEFRTYCL 452
CCY54304       391 NSEYFCSIMHELRnDMS---YRAIVDELIEVP-EAADT--RDTEAVKRIATAYLKLLYPNvr---eaSDIsVREFKRYCL 461
WP_022459609   373 NVEFFSEVLHQLRtATE---YATIVNQSIAVP-EGADM--RHLKAVKRIASAYLKLLFPHil---kkEDMdIAEFYTYCL 443 Bacteroidales
CCZ11708       377 NVEYFSEILHTMRiQNS---YGLLFDELVEFE-AKSDV--RDSKAIKRIATAYMKLFFPHwq---kvEDVnKEMFDLYCL 447

WP_015261294   465 QPAKRMQETVLKQMKIINPGMFGNTGFA 492 Desulfitobacterium dichloroeliminans
jgi:Kcr_0570   455 NIAIEMRKLVRDWLRLKLPHEYSNELEV 482
WP_011753460   437 RGIVGLRNNVSRLLTAISPSEFPPKKLE 464 Thermofilum pendens
WP_012186111   445 GHVVELRQRIRDWMHKLSPSEFQREELS 472 Caldivirga maquilingensis
jgi:Cyast_2594 455 KPACLLRQQIHSLIYNLDD-EFKQYGKE 481
WP_234397974   447 KPALEKRAIVKRQIHLMDP-EFKAAIPD 473 Coprothermobacter proteolyticus
jgi:Anamo_1578 453 DLALKMRGIIRHQLHLMDS-EYSDTLPD 479
CCY54304       462 DRARKMRDTIKYQLGILDE-EYRGKDIP 488
WP_022459609   444 KPAVHRRDIIRRQCANIDH-ESSFSKPM 470 Bacteroidales
CCZ11708       448 QPAIYRRGIIKEQCHLVDS-EFKARMPE 474
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