Conserved Protein Domain Family
DXP_synthase_N

?
pfam13292: DXP_synthase_N (This model is not part of the current CDD release)
1-deoxy-D-xylulose-5-phosphate synthase
This family contains 1-deoxyxylulose-5-phosphate synthase (DXP synthase), an enzyme which catalyzes the thiamine pyrophosphoate-dependent acyloin condensation reaction between carbon atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate, to yield 1-deoxy-D- xylulose-5-phosphate, a precursor in the biosynthetic pathway to isoprenoids, thiamine (vitamin B1), and pyridoxol (vitamin B6).
Statistics
?
PSSM-Id: 520649
Aligned: 140 rows
Threshold Bit Score: 359.038
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
jgi:Psta_3970   7 LSKIESAADLKTMSNAELTQLGAEIRDVLCNLLSTRTAHFASNLGVVELCLALHSVFDFRRDRLIWDTGHQIYPHKLITG 86 
Q8EWX7          8 IDKIPNYEDFKKMKLHELLDLAVLLRKKIIDISENKSAHLSSNLGIVELSMALLYVFDSPQDLIAYDTGHQCYVHKMITD 87  Malacoplasma p...
Q6MDK6          6 LSNLNHPNDIKNLSYSDLKYLAHEIRQRIIEVLSVNGGHLASNLGVVELTLALHKVFESPDDKFIWDVSHQTYVHKLLTG 85  Candidatus Pro...
WP_012921353    4 LDTVGGPADLKDLTDQQLADLAAEIRDVLVETVSRTGGHLGPNLGMVEITLAMHRVFDSPRDRLVYDTGHQTYVHKLLTG 83  Kribbella flavida
A1SKM6          4 LDSIASPADLRGLSDAQLEQLASEIRDLLIRTVATNTGHLGPNLGVVELTLAIHRVFDSPRDRVVFDTGHQAYVHKLVCG 83  Nocardioides s...
WP_013126525    4 LSTIESPRDLRRLDQAQLSQLASEIRAFLIEKVSATGGHLGPNLGVVELTLAIHRVFSSPVDPVIFDTGHQAYVHKIVTG 83  Tsukamurella p...
A0QW19          2 LEQVRGPADLQHLSQSQLRDLAQEIRQFLIHKVAATGGHLGPNLGVVELTLALHRVFDSPHDPIIFDTGHQAYVHKMLTG 81  Mycolicibacter...
WP_012834063    4 LDRINSPADLAALSPAEMDALAVEIRDFLIAKVSATGGHLGPNLGVVELTLALHRVFDSPHDPVIFDTGHQCYVHKILTG 83  Gordonia bronc...
Q5YTA2          4 LSRVDTPEDVRRLNVAELRELAEEIREFLVRKVAATGGHLGPNLGVVELTIALHRVFDSPADPLIFDTGHQAYVHKILTG 83  Nocardia farci...
WP_012890378   35 LPRINGPGDLRRLPPGRLPELAGEIRRFLVDKVSATGGHLGPNLGAVELSIALHRVFASPRDAIVFDTGHQAYVHKILTG 114 Streptosporang...
jgi:Psta_3970  87 RYHEFSTIRTKGGLMGYPNPQESEYDLFMTGHAGSSVSTVLGLKSGDDLMGqS-DRKSVAVIGDGAFPSGIVFEALNNA- 164
Q8EWX7         88 RADKISTIRESNGLSGFQEPNESIHDFISTGHSGNILSICQGFIEKNN--SkS--KSVIPVIGDAAISNGLAFEALNNI- 162 Malacoplasma p...
Q6MDK6         86 RNDRFHEIRQFKGLCGFSHPKESIHDHFHAGHAGTALSLALGVAKNRDLTK-R-KDYIIPIIGDATLTCGLTLEALNNIs 163 Candidatus Pro...
WP_012921353   84 RAAEFGSLRQQGGLSGYPSQAESEHDIVENSHASTSLSYADGLAKAYRLRG-E-DRHVVALIGDGGLTGGMAWEALNNIa 161 Kribbella flavida
A1SKM6         84 RAASFGTLRREGGVSGYPSQAESPHDIVENSHASTALSYADGLAKAYTIRG-E-DRHVIAVIGDGALTGGMAWEALNNIa 161 Nocardioides s...
WP_013126525   84 RHDQFDTLRQAGGLSGYPCRSESEHDWVESSHASASLSYADGLAKAFELKG-E-QRTVVAVVGDGALTGGMCWEALNNIa 161 Tsukamurella p...
A0QW19         82 RSEDFDTLRSKDGLSGYPSRSESDHDWVESSHASAALSYADGLAKAFELTG-HrNRHVVAVVGDGALTGGMCWEALNNIa 160 Mycolicibacter...
WP_012834063   84 RKDGFDALRQKDGLTGYQERAESPHDWVESSHASAALSYADGLTKAFALTG-QtDRTVVAVVGDGALTGGMCWEAMNNIa 162 Gordonia bronc...
Q5YTA2         84 RKDRFDDLRKQGGLSGYPSRAESPHDWVESSHASAALSYADGLAKAFALGG-Q-DRHVVAVVGDGALTGGMCWEALNNIa 161 Nocardia farci...
WP_012890378  115 RQGGFDRLRQAGGLSGYPSRAESVHDLVENSHASTALSYADGLARAFQLRGhT-DRHVVAVIGDGALTGGLALEAVNNL- 192 Streptosporang...
jgi:Psta_3970 165 GGLK-KDLLVVLNDNKMSICPRVGGVASYLDRLRTTPFYAGLKSEVIKAL-NRv--PVlGDPVERFLAQLKEGVKAGLHg 240
Q8EWX7        163 AYNK-TPMLIIINDNGMSISKNVGALHKIMSKFQMSKSVFLTEKILRKILfKKewsKKiYWSIYKSFSKLSKFFKGK--- 238 Malacoplasma p...
Q6MDK6        164 REL--KRFIVILNDNAMSISKNVGAITHILSRLLSNPTTNKIHQELDTIV-SKi--PNyGPILSQQGHKITESLKNLVSp 238 Candidatus Pro...
WP_012921353  162 AARD-LKLVIIVNDNGRSYSATVGGLATHLTSLRTNPRYEKILDLVRTNL-GRt--PYvGPPMYEVLHGVKKGLKDVLA- 236 Kribbella flavida
A1SKM6        162 IAKA-SKLVIVVNDNGRSYTPTIGGLATALTSLRTNPRYENVLDLVKRRL-NAv--PGvGPAAYDALHAMKKGLKDALA- 236 Nocardioides s...
WP_013126525  162 AS-Q-RPVVVVVNDNGRSYAPTIGGLATHLSGLRTQPEYEKLLGEARQRL-RGt--PVvGEPLYSVLHGMKAGIKDMLS- 235 Tsukamurella p...
A0QW19        161 TS-R-RPVVIVVNDNGRSYAPTIGGLAEHLAALRLQPGYERVLEEGRKAV-RGv--PLiGELCYQCIHSIKAGIKDAIA- 234 Mycolicibacter...
WP_012834063  163 AA-E-RPLVIVVNDNGRSYAPTIGGLASHLSGLRLQPGYERFLDESRKVV-KQl--PVvGDSAYAVLHGVKSGLKDLLT- 236 Gordonia bronc...
Q5YTA2        162 AAPD-RPVVVVVNDNGRSYAPTIGGLADRLTALRTQPAYEHALDAGKRLL-KSi--PRvGESAYSMVHAVKAGIKDAVS- 236 Nocardia farci...
WP_012890378  193 GAAPgRPAIIVLNDNGRSYAPTVGGLASHLATLRR-------------------------PGVPSPRPGV---------- 237 Streptosporang...
jgi:Psta_3970 241 GM-LFEDLGFRYLGPIDGHNLPLLKKYLQMVKDL--KGPILLHVVT 283
Q8EWX7        239 -N-FFESLGFHYFGVIDGNNLKKTINVLKRIKNIvpFGPTILHVKT 282 Malacoplasma penetrans HF-2
Q6MDK6        239 AV-YFEQYGLSYIGPIDGHDTKKLVDVLEGVKDS--NWPVIIHVLT 281 Candidatus Protochlamydia amoebophila UWE25
WP_012921353  237 PqgMFEDLGLKYVGPVDGHDRAAMEDALAKAKAF--GGPVIVHAVT 280 Kribbella flavida
A1SKM6        237 PqgLFEDLGLKYVGPVDGHDRAAMEQVLAQAKRF--NGPVIVHAIT 280 Nocardioides sp. JS614
WP_013126525  236 PqaLFGDLGLKYVGPIDGHDEEAVEDALRRARDF--GGPVVVHVIT 279 Tsukamurella paurometabola
A0QW19        235 PqvMFTDLGIKYVGPIDGHDEHAVESALRHARGF--NAPVIVHVVT 278 Mycolicibacterium smegmatis MC2 155
WP_012834063  237 PqaMFTDLGLKYVGPVDGHDVAAVESALRQARDF--GGPVIVHVVT 280 Gordonia bronchialis
Q5YTA2        237 PqeLFSDLGLKYVGPVDGHDVVAMESALRRAKDF--GGPVVVHAVT 280 Nocardia farcinica IFM 10152
WP_012890378  238 PN-VFESLGFSYLGPVDGHDIGALEGALRQARAL--RRPVVVHAVT 280 Streptosporangium roseum
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap