8QGY


Conserved Protein Domain Family
MAP3K_TRAF_bd

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pfam13281: MAP3K_TRAF_bd (This model is not part of the current CDD release)
MAP3K TRAFs-binding domain
This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs) and, together with the PH-like domain, constitutes the central regulatory domain of ASK1.
Statistics
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PSSM-Id: 520645
Aligned: 24 rows
Threshold Bit Score: 327.683
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8QGY_A         79 LFYHLGVRESFSMANNIILYCDT-NSDSLQSlkeiicq--kntmctGN-YTFVP-YMI----TPHNKvyccdssfmkglt 149  human
XP_009009432   78 LSYHIGVRESMSMPETVILLHDT-NPGFTISvnl----------tsKK-TDFFP-YKL----GSDGKcvvvdagata--- 137 
XP_009031506   92 MFYQIGIRENLGRPETIIMIYDT-NPERTLAlkl----------ssGS-FDFLS-YKL----DRLGKnlvaefsglsl-- 152 
Q21029        136 LCYHIGVRESMGQSYNMILTYWSpDPEYHIMda------------lKKtHAHLP-MIVyihhQDSNQlqsydknnnddd- 201  Caenorhabditi...
XP_002112960   54 LLYQLAVRESFDMRHNIVLLNDN-DDEATHAisl----------svTS-HTFLP-YTI----NPSNTafisrkftvg--- 113 
EDS31404      148 LCYHLGVRESFEMKENIVIYEDE-ESEATLRmki----------scGN-YTFVP-YRV----VEGGRgcvvtnpgk---- 206 
XP_008201568  119 LSYHLGVRERFNMKYNILIYNDT-DTEATERlk-----------csTQ-YPCIS-YIL----TEDGMcvttg-------- 172 
EFN86048      101 LFYHLGVRESFGMKENILLYNDV-DTEATIRlkl----------scGS-YTFVS-YRV----VECGScvatnpaas---- 159 
XP_002432644  116 LFYHLGVRESFGMKQNIVMLNDQ-NPESTLRlkvieleknnndddnDN-RIFLSnSRL----CDFKNnfcvttnptaa-- 187 
2_pfamImport    1 LSYYLGCRHNIGMNQNIILCNNL-DDEVMLRlkl---------pcdDS-ITFIS-YKL----ADCGTclitnpl------ 58  
8QGY_A        150 elmqpnfelllgpICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTG--KELAAELaRIRQRVDnievlTADI 227  human
XP_009009432  138 ---aepsgtktleKSQTLLHFLKKVMKRVETTSKIHIKEKFLSDLRKIRENNKG--PDLERVVvSMRDRMDdpqllSSDI 212 
XP_009031506  153 ---melrsdqpgvKNIGFQQCLRKVLKAYACKTRAQVKEKFLSELKKARETWKG--EDLINVLaSIKSRYYgpelySSDI 227 
Q21029        202 -skppfartnvpaKTITFQHRMKQVLKSVQVEASAHSREKFMSDLRKAREITDG--DQKNDYLdKMRTRLDnpdvlHPDT 278  Caenorhabditi...
XP_002112960  114 -------igrrdiqgmTLLSGIKRKIKEFEINKRKHIKEIFLRDLRRAREKLSK--EDLVKELtRLKATLDdpalfTADI 184 
EDS31404      207 -----ggyleeveCKVGLLGRLRKIFQDVEIQSKAHLREKFMADLRSLRDQYAGnvEELQKMLrNMRRRLDdphvlSKEI 281 
XP_008201568  173 ---------rlndGGELLNQRLKRSLQDVEIQSKAHMKEKFLADLKKLKEQKSG--EELQKSLnNIRRRLDdpnvlSGDV 241 
EFN86048      160 ----ritgeeaidPKQHLTLKLKKLFQDVEIQSKAHMKEKFLADLRKARETYSG--EELSRALnNMRKRLDdpnvlSGEV 233 
XP_002432644  188 ---kfqtddaaldMKQPLNVKLKKLLQDVEIQSKVHMKEKFLSDLRKAREIYAG--AELSKVLhNLRARLDdpnilSGDV 262 
2_pfamImport   59 -------ylgndeSIKSVAVTLEKLFKDVEIQSKVHTNKKFLSD--------SG--EVLREKLlILRNHLEdp-cvTVDI 120 
8QGY_A        228 ViNLLLSYRDIQDYDSIVKLVETLek-lpTFDLASHHHVKFHYAFALNrrnLPGDRAKALDIM--IPMVQsEg------- 297  human
XP_009009432  213 VfNMLLSYREIQDYNAMVTLVEEIed--vRSQVNETMAIQQLYAFALNrrkKPGDRDKALEFLshLQCIEqMe------- 283 
XP_009031506  228 VlNMLLSYRDVQDYSSMVELVEDMed--lSLNITDTVAIQHLYAFALNrrnSEGDRDKSLQRI--LKAIGmSd------- 296 
Q21029        279 VsLMMLSYRDNQNYGGMIRLVDDLkripdCLKVVDTPVIRYQYAFALNrrnKDGDRDLALNTV--LSLVEgTteneekng 356  Caenorhabditi...
XP_002112960  185 LhNLMLTYRDIQDYDSMVKLINELp---nHKETMKGP-IQQLYAFALNrrnKEGDRDKAIQVL--EKMLLkSe------- 251 
EDS31404      282 VqTYMLSLRDVQDYDAMVQLVDDLqtvpnKQNYINTGNMNYLYAFALNrrnKEGDRDKALKSC--TKALEkKe------- 352 
XP_008201568  242 VlNMLFCFRDIQDYDSMVQLVDDLrt-lpAARKYLNSYILYLYAFALNrrkQDGDREKALNVC--IEALEkRe------- 311 
EFN86048      234 VlNVLISFREIQGYDAMVQLVDDLrtiptHKNYINTPAIRYLYAFALNrrnKEGDRERALKVI--EKALEkKe------- 304 
XP_002432644  263 VlNLLISFREIQDYDAMVTLVDDLktvhtKKSYISTPLIRYLYAFALNrrdKPGDKERALNVI--EEALKhKe------- 333 
2_pfamImport  121 LyKMMEALRDVQDHEGMVQLVEDIqaisdKRHFTQTPLLQYLYSFALHrsnKPGYRQKALLVI--EHALEkNk------- 191 
8QGY_A        298 QVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLlaaghQFESSFELRKVG--VKLSS 375  human
XP_009009432  284 TPIPDLICLLGRIYKDKFTDSGRQDTEALTNAIKWYQKGFEAQPNEYAGINLATLLvisgeKFSQSTKLQQIA--LTLNN 361 
XP_009031506  297 TDVPDLLCLCGRIYKDKFVESDGADGESLKEAIKWYQKGYDAQPNEYAGINLATLLvvsgeQFQTSATLKRIG--QTLTT 374 
Q21029        357 PLSPDVVCLAGRIYKDKFIASNYEDRESLNSAIEWYRRAFEMSPLEYSGINLTTLLrasgeHFENNLEMQQIA--VVLNS 434  Caenorhabditi...
XP_002112960  252 NHVPNVLCLFGRIYKDKFSESEYTDNDSRDKAIHWYRKGYKIQPNEYAGINLATLLviageRFSLSAELQQIGntMTLNT 331 
EDS31404      353 NHFPDMLCLCGRIYKDIFVESNRTDQESLQNAITWYRKSFEIQPNEFAGINLATLLviegkDFSDT-ELQHIG--MVLNN 429 
XP_008201568  312 NHFPDMICLCGRIYKDKFTESDYKDEKSLREAIYWYRKGFEVQPNEYAGINLATLLviggaDITGNEELQRIG--MVLNN 389 
EFN86048      305 NHVPDMLCLCGRIYKDIFVESRHTDQESLNNAIHWYRKGFEVQPNEYAGINLATLLviagnEFSKSEELQHIG--MVLNN 382 
XP_002432644  334 NHFPDMICLCGRIYKDKFVKSDYQDSESLKNAIHWYRKGFEVQPNEYAGINLATLLviaggEISKSSELQHIA--LVLNN 411 
2_pfamImport  192 SFLPDLICLYGRIYKDKFVESIFEDRSALQHAIKWYRKAFQIQPNLHAGINLATLLlvagnEFSKSEELQNID--IFLSN 269 
8QGY_A        376 LLGKKGNLEKlQSYWEVGFFLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTtE-QPvakqelvd 454  human
XP_009009432  362 LIGRKGYLSTlTDYWTVATFFEISVLAEDYSKAVQAAECMMKLDPPDWYLKSTMENIRLITSSRQEEnInHNkrdkelfn 441 
XP_009031506  375 LIGHKGLLQSlTDYWDVATFFEFNVLREDYSKAVQAAECMAKMDPPSWYLKSTLGNIDLINAYKKKDsNkEEsieeklyd 454 
Q21029        435 LLGRKGALQNlMEYWDVATYFEVSVLAENYQKACEAALMMVKLKPPVWYLKSTMENIKLINRCAATIs--PIekekqqfl 512  Caenorhabditi...
XP_002112960  332 LLGRKGSLSSlEDYWDVATFFEVSVLAEDYTKTIIAAECMFKLKPQTWFLKSTLGNISLIKSFRKDPeDiMEtrdykvys 411 
EDS31404      430 LIGKKGSLSSiKDYWNVATFFEISVLAENYAKAIQAAECMFRLKPPKWYLKSTIGNITLIDYSRRKSdEsSIsieqqifq 509 
XP_008201568  390 LIGKKGSLSSlQDYWDVATFFEISVLFQHYSNALQAAECMFKLKPPDWYLKSTVGNIQLIDRFRKKRdE-EGspeekifh 468 
EFN86048      383 LIGKKGSLSSlKDYWDVATFFEISVLAEDYSKAIQAAEYMFKLKPPNWYLKSTIGNISLIDRFRKRNeEaEIspeeqifs 462 
XP_002432644  412 LIGKKGSLSSlKDYWDVATFFEISVLAEDYTKAIQAAECMYNLKPPNWYLKSTIGNISLIDRFRKKNeEsESspeeqifq 491 
2_pfamImport  270 FIGKRGNLTSiNDYWIVATYFEMNVLTENYSKAMKAAECMFKLKPLIWHYKSTIENIKLISEFRKKRg--EInalekylk 347 
8QGY_A        455 fWMDF 459  human
XP_009009432  442 fWIDF 446 
XP_009031506  455 fWTEY 459 
Q21029        513 fWSEF 517  Caenorhabditis elegans
XP_002112960  412 fWLDF 416 
EDS31404      510 fWMEF 514 
XP_008201568  469 fWMEF 473 
EFN86048      463 fWMDY 467 
XP_002432644  492 yWMEY 496 
2_pfamImport  348 yWMKY 352 
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