Conserved Protein Domain Family
DUF4043
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pfam13252: DUF4043 
Protein of unknown function (DUF4043)
This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 369 and 424 amino acids in length. There is a single completely conserved residue G that may be functionally important.
Links
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Statistics
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PSSM-Id: 493230
Aligned: 6 rows
Threshold Bit Score: 288.28
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5F7T0         6 NTAYGDPQAMMKQAAGLFAMHMQRNSTLNRLagkmpagtagaeatlrkQTTQHMPVVRCQDLTRGmGDEIRFNLVNPVSA 85  Neisseria gonor...
WP_013946877   3 TTTVLSGLELTKWRSKFIMEYIRDTGFEPYM-----------------GDSAMDIISVVNDLQTD-GYTIRIPLLGKLNG 64  Hyphomicrobium ...
WP_012169374   5 RFGVNDALAVKLWSKGLDAEALKATPIAPLI-----------------GDGTNSIIQRKTETGKGsGDKVTYGLRLQLTG 67  Azorhizobium ca...
1_pfamImport   1 TTSSLSIDQVAFDRLAYFALRSELLFD---------------------QAADVQPVAQAMP-----GTGVTFTIFADIAA 54 
Q2Y914         5 NVASGSSLAVKHYSAALFANTLKGSTAIDSLvgpvepsv--amqkiagQTNPGMPIVRIDNLMKSaGDVVSLDLVDTVGG 82  Nitrosospira mu...
Q6ALP3         4 NIPYGDPIACTKQAVGLFAATTQRQTNLNRLagkfptqk-gaeknlrnQTSTDMPIVRCRDLQKSaGDEVTFDLINPIGG 82  Desulfotalea ps...

Q5F7T0        86 LPIMGDNTAEGRGVGMSLSEAGLRVNQARFPVDGGg--TMTNQRSPADYRALIRPAAQSLMD---RYADQTLLVHMAGAR 160 Neisseria gonor...
WP_013946877  65 AGVTGNTSLTGNEQQMDQYYQDLSWEFRRQAVLAT---KKDRAKSAVDFMAQARPSLKDWSTenvKYRLIEAFHKMSDGT 141 Hyphomicrobium ...
WP_012169374  68 DGFTENEVAEGNGESLSIYSDGLLINELGHVVSAAsnnTIDAQRVPFEIRSECKDGLADWFA---KRMSVSFFNQVCGFT 144 Azorhizobium ca...
1_pfamImport  55 ATSTLNEVTDVTPTALSDSQVTVTLAEYGNAVVTT-----------------AKLRGTAFLD------VDSAAANIIGYN 111
Q2Y914        83 EPLMGDVNREGRGSALSFSSMEIKIDLSSKVIDAGg--SMSQQRTKHQLREIALAQLSGYFP---RLDAQETLVHLAGAR 157 Nitrosospira mu...
Q6ALP3        83 KPIMGGDMAEGRGVSMTFSNDKLRINQTRKPINAGd--TMTQQRTPHQLRTLARAAGYGYME---NLEDQLTLVHMAGAR 157 Desulfotalea ps...

Q5F7T0       161 GFHDNiewgvplagdpkfNDYAVNPVKAPSKNRHFTASGDAVTGVGDNGGelkIASTDLFTMDTVDSMRTVLDQIPLPPP 240 Neisseria gonor...
WP_013946877 142 PFSSA-------------NATQRNAFAAGNSDRILFGATRANYSATHATG---LTAIDNTADKLSTAVGSLAKFMARQAR 205 Hyphomicrobium ...
WP_012169374 145 AETRTk-----------yAG--LNAIAAPSSGRVLRPTGSNDQA---------LGSSNLFTLDLIDKAKEMAETASPKIR 202 Azorhizobium ca...
1_pfamImport 112 AGDSI--------------DQVVREVLAGGSNVAYATGGASAPS-----SrvtMAVDDLL---VANDIRKQVAA------ 163
Q2Y914       158 GSQTGsdwtvplqsapnfSSIMVNPVKAPTYNRHFVVNGANLTSGGQQLGs--VVSTDALRLSHLDLLRKRLDDMDQPLQ 235 Nitrosospira mu...
Q6ALP3       158 GFHNNiewvvplasdsdfTATCINPVRAPSGNRHFIANGGYLEKVSATAGeinIETTDVMQFGLMDALRAVVDSMPLPPP 237 Desulfotalea ps...

Q5F7T0       241 IVKFEGDKAAGDSPLRVWLLSPAQYNRFAAD---PKFRQLQASAIARa-sQANQNPLFLGDAGLWNGFILVKMPRPIRFY 316 Neisseria gonor...
WP_013946877 206 PMIRPFKTGTQGREYYVMFCHPLGFRDLKAD---TVMQQANRDARAR---DVDSNPLFQDGDLIYDGVIYREIPEFYQGK 279 Hyphomicrobium ...
WP_012169374 203 PVK------VGSDDYYVCYLHPYQVTDLRTTtatGQWLDIQKAAMAGg--MVDKSPIFTGALGVYNGVVLRSAVDVTQGV 274 Azorhizobium ca...
1_pfamImport 164 ---LRGANVATFNGSYIGFIHPDVSYDFRSAtdaSAWRTPAN--------YVDPTGIYNGEIGLFESVRFIETPRAKVFT 232
Q2Y914       236 SVKLAGDRAAQTSKMWVFLATPNQYSLLLTE---GSLRAFQQNAINRaayFDERHPLFAGEVGMWNGILVIKNERAIRFM 312 Nitrosospira mu...
Q6ALP3       238 PVKFHGDSMASDDPLRVCLATPQQYASFIAS---GNFRTLQANAMQRa-sTAGGNPLFKGEAGLWNGILIVKMPKPIRFF 313 Desulfotalea ps...

Q5F7T0       317 AGDEMKYCADKFSeaesgl--kipasfADKFAVDRSVILGGQAVleAFANTgkHGGMPFFWSEKelDHGNRVETLVG-TI 393 Neisseria gonor...
WP_013946877 280 DADSGLNADTTFS--------------NGSIQCGVSFLCGAQAI--GFVNK--QAAIPTSRADD--DYGFLKGVGIE-FA 338 Hyphomicrobium ...
WP_012169374 275 NSSTS----------------------AAISTVRRAVFLGAQAAviGFGQD--NGPTRYRWNEElfDHKRRMEVSAW-TI 329 Azorhizobium ca...
1_pfamImport 233 NAFNGAGAAGT----------------GDSYAT---LIMGRQALakAFSTQdgNGATPKIVRGNvtDILMRLQPLGWyWL 293
Q2Y914       313 PGESTKIVTAANAttatetdqavngalTAGYAIERGLLLGAQALgvAYGKTr-VSGMQFGWKEHwyNFESNLEVMGE-KV 390 Nitrosospira mu...
Q6ALP3       314 AGDPINWCANINSsaetttdlvpasfaAAGYAVDRALLLGGQALaqALGKHq-KSGVPYFWSEKelDHGDKLEILAG-MI 391 Desulfotalea ps...

Q5F7T0       394 RGVAKTRFAVDVGGGAKeITDYGVTVVDTVVPL 426 Neisseria gonorrhoeae FA 1090
WP_013946877 339 DGIDKLRWNNNPGGINN-GKDVGMVTVYHAAVE 370 Hyphomicrobium sp. MC1
WP_012169374 330 FGLKKTQFNNV---------DFGTIVISTYAAA 353 Azorhizobium caulinodans
1_pfamImport 294 GGYGRFR-------------EASLRRIESASSI 313
Q2Y914       391 CGKAKTRFSIDDGTGFRvPTDFGVIAVDSAVPL 423 Nitrosospira multiformis ATCC 25196
Q6ALP3       392 DGKSKIRFEVDYGADGKqPTDHGIIAIDTAVKI 424 Desulfotalea psychrophila
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