Conserved Protein Domain Family
SQHop_cyclase_N

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pfam13249: SQHop_cyclase_N (This model is not part of the current CDD release)
Squalene-hopene cyclase N-terminal domain
Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclisation of squalene into hopene in bacteria. This reaction is part of a cationic cyclisation cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Statistics
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PSSM-Id: 493228
Aligned: 103 rows
Threshold Bit Score: 265.517
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
TDZ15627      41 QAAEHAYSQMKPDGHWYLEVRSSISFTVQWICIRQIVgPAV-SPEEADKFRKWLLSQQNhEDGSWGLA-PavhDWA-GDV 117
WP_012098896  22 AASQYLYRTQQ-RDHWRAELESNVTVTAEYVLLRQALgLDL--EERRDALVRYLCSRQK-ADGSFGIA-S---TLP-GDV 92  Anaeromyxobacte...
1_pfamImport   3 PAADYAYSLQKPDGHWLTELRSNISFTAQYVCLREIAgISLrQSEDRNHFRKWLLAQQN-PDGSWSLA-P---GES-GDL 76 
XP_003718197  21 HATEFARDTLVNKEHWCGWVLSNVTVTAEWIFLQYILgLEM-SNEDRRGFLKHFTSSQR-PDGSWSLAtQ---TTTgGEL 95 
2_pfamImport   3 LAVGHSLDLQRADGAWCGEVHSNATFTSQYVFLQQQIgLPL-DPTEIEGLSRWLFSQQN-EDGSWGLG-P---GLG-GDV 75 
XP_001269139  32 KATSYAWEII-SNRHWCGELESNVTVTCEHIFFLYVLyQHI-DPDEGSQYRQWLLSQQN-ADGSWGIA-P---NYP-GDV 103
CAK45506      30 LATEYALSSIRSDGHWCGELRSNVTITAEYIFLRHALgLDL--RTDNAAYCRYILSQQN-CDGSWGLA-P---EYP-GDV 101
XP_002566308  24 LSNDYALGLVHPDGHWYGEMNTNVTVTAEYVFLRQALrLDL--KTDIAAYCHYLLSQQN-SDGSWGLA-P---EYP-GDV 95 
Q2U3C4        28 RSMDYAYNVVRSDGHWCGEMSSNVTITAEYIFLRQALgLDL--KTDGAAYCRHILSQQN-SDGSWGLA-P---EYP-GDV 99  Aspergillus oryzae
WP_022543350  10 RLKQQLLSEQTPDGSWNHPFDTGCMTDIYMIVLLRTLeEED-EEELIKELAKGILSRQG-KDGAWRLF-H---DHHeGSL 83  Bacillus
TDZ15627     118 STTVEAYFGLKLLG-TPIESKAMRKARAFTLRNGGVARVGVLTQLVLALFGIVAWKDMAQVPAELMALPAGLsPVNIYSF 196
WP_012098896  93 STTAEAYLALRLLG-LDREDERLRAAERFIRGAGGLARVRVFTRINLALFGLFPWEAVPTVPAELIFLPRWA-PVNVYRL 170 Anaeromyxobacte...
1_pfamImport  77 SISVEGYFALKLLG-VSSDDKAMRLAKEFILSRGGLPLVGIITQFLLAVFGLIKWDQIAQVPAELMLMPTWS-PVNIYAF 154
XP_003718197  96 SCTIEAYLALKILG-VSPEEDYMVRARDYVRSHGGAEKMRMLSRFHLAMFGLIPWAAVPQMPPELIFMPSWS-LVNIYKF 173
2_pfamImport  76 STTTETYLALKILG-VSPEDPRMAAARTSIIKAGSLPATRMFTRVFLASFGLIPWSAVPPLPAELILLPTLF-PVNIYNL 153
XP_001269139 104 STSAEAYLALRIIG-MSPDSPELFQARTFIRAAGGLSKMRMFTRIFFAEFGLVPWTAIPQLPAEFILVPAHF-PISIYRL 181
CAK45506     102 STTTEAYLALKLLG-TSPDMPAMQQARAFVRKAGGAEKVRVFTRIFLATFGLFPWDAVPQLPVELILLPSSC-PINMYTL 179
XP_002566308  96 STSTEAYLALKILG-TSPHTPAMRNARAFVLKAGGIARVRIFTRIFLATFGLFPWSAVPELPVELMLLPSIC-PINIYKF 173
Q2U3C4       100 STTTEAYLALKMLG-LSTDAPAMQQAKAFVLNAGGVAKVRVFTRIFLATFGLFPWKAVPQLPVELILLPSAC-PINIYKF 177 Aspergillus oryzae
WP_022543350  84 SLTIEAYYALLYSGyYEKNHPALVKARRVITKGGGLKKAGMYTKIMLALTGQYPWPLLFPVPMEVILLPRSF-PLNMYDI 162 Bacillus
TDZ15627     197 SYWSRVSAVPVMLLKHHQPIFSLsvvgSDgeevlgATFLDEIFVNpLERRLTSIPELstlwrEGQLgRLA---------- 266
WP_012098896 171 ASWARSTMVPLFVLFHHRPVFAL----PGga---gSDWLDHLWLGpGDKRVPYR-------------TSVmetvrrhgpg 230 Anaeromyxobacte...
1_pfamImport 155 AHWSRVTAVAMMVLRHHQPTFPL----PAdlmvpeKSFLQELYPDvTDQRLRFYPSVsrlwqAGEYgRCI---------- 220
XP_003718197 174 SSWARCNIVGLCMLRVHEPLYAL----PNgkq-ldNDYLDELWLDpYHKAIPYT-------------VPYlqlmqt--sp 233
2_pfamImport 154 SSWARATCVPLLLIRHHEPLHSL----PNgrh-aeNDFLDELWTKdIPRDFCYT-------------TPLsrmwrlg-dy 214
XP_001269139 182 ASWARSNVVPLLIIAHHRPLYPL----PNglh-kqNPFLDELWLDpATKPLPYG-------------Sldptd------p 237
CAK45506     180 ASWARGTIAPLLIICHHQPVYAL----P-------EDYLDELWLDpTDKNVPYG-------------SSLrdllsrg-di 234
XP_002566308 174 ASWARGTIAPLLIICHHQPVYSL----PNgks-tdNDYLDELWVDcTNKSVPYG-------------LPLwdlmsqg-ef 234
Q2U3C4       178 ASWARGTIAPLLIICHHQPVYAL----PNgvf-aeNEYLDELWQDsTNKSEPYS-------------PSIwellsqg-di 238 Aspergillus oryzae
WP_022543350 163 SVFGRSNLIPVILLGNKKFSRKTal-sP---------DLGDLSVRdd-----ddPWPelrsaEWRSlTSF---------- 217 Bacillus
TDZ15627     267 ----CTIIDKAASVVEpLL----KRSMLRKHCLDQCVQYIVNHLD-AGGFGSLTISNFLCVVGLHASGFPASHPVMGHLT 337
WP_012098896 231 wkafFNAADAWLRVHD-RLrhlpPLGRLRTEALRACEEWILARQEaSGDWAGIFPPMLNGVLALHVAGHGLDAAPVRRGL 309 Anaeromyxobacte...
1_pfamImport 221 ----AALADKAVALMDpIV----KKTSLRAYSLSQCVQFMIKRQT-ESGYASFWPANFNCILALYCQGYEFKDPAIKCLL 291
XP_003718197 234 lgvlFQLGDLFLWLLS-FL----GFWFLRRWAVSSSIQWTLDHQEpSGDWGGIYPPMHHNILALMLEGWSQDDPVIQRGI 308
2_pfamImport 215 agifFTSADHGLRFLG-QY----FHSPLRNLSRRKIINWILDHQEqSGEWAGYWPPQHNNIWALSLEGYSLDHPVLRRGI 289
XP_001269139 238 lsfvFTILDKALSYLGgLR----RCP-TRGYARRRCIQWILQHQEkAGDWAGIIPPMHAGIKALWLEGYKLHDEPIQLGL 312
CAK45506     235 tglaFSVVDNLLYYLNgLR----SVPLLRSYARRKCIQWILERQEpTGDWAGIFPPMHASIYAFVLEGYELNDPPVRLGI 310
XP_002566308 235 aglaFGVLDKVLYQLNgLR----SIPLIRAYARKQCIQWILERQEkTGDWAGIFPPMHANMYAFTLEGYKLDDDPVRLGF 310
Q2U3C4       239 tgltFSLLDKLLYQLNgLR----SIPLLRSYALKQCMKWILERQEpTGDWAGIFPPMHASVYAFVLEGYKLEDPPVRLGI 314 Aspergillus oryzae
WP_022543350 218 ----LAAGVKALVG---------IPRQIRAWSIEKAREYMQSHTEpDGTLYNYFSSTFYMIFALLALGGGPEEPAIRNAV 284 Bacillus
TDZ15627     338 RAMQDALWEDDD 349
WP_012098896 310 EAIERFAVSDRE 321 Anaeromyxobacter sp. Fw109-5
1_pfamImport 292 HAIDSFYIWKDE 303
XP_003718197 309 GACQRFLAEDPA 320
2_pfamImport 290 AAVKSFVLHDAT 301
XP_001269139 313 AAIERFTWTDNR 324
CAK45506     311 QALENFAWEDEK 322
XP_002566308 311 QALERFAWEDEK 322
Q2U3C4       315 EALENFAWEDAK 326 Aspergillus oryzae
WP_022543350 285 AGLKRMTVKADg 296 Bacillus
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