Conserved Protein Domain Family
SQHop_cyclase_N

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pfam13249: SQHop_cyclase_N (This model is not part of the current CDD release)
Squalene-hopene cyclase N-terminal domain
Squalene-hopene cyclase, EC:5.4.99.17, catalyzes the cyclisation of squalene into hopene in bacteria. This reaction is part of a cationic cyclisation cascade, which is homologous to a key step in cholesterol biosynthesis. This family is the N-terminal domain.
Statistics
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PSSM-Id: 520633
Aligned: 103 rows
Threshold Bit Score: 265.517
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
TDZ15627      41 QAAEHAYSQMKPDGHWYLEVRSSISFTVQWICIRQIVgPAV-SPEEADKFRKWLLSQQNhEDGSWGLA-PavhDWA-GDV 117
WP_012098896  22 AASQYLYRTQQ-RDHWRAELESNVTVTAEYVLLRQALgLDL--EERRDALVRYLCSRQK-ADGSFGIA-S---TLP-GDV 92  Anaeromyxobacte...
1_pfamImport   3 PAADYAYSLQKPDGHWLTELRSNISFTAQYVCLREIAgISLrQSEDRNHFRKWLLAQQN-PDGSWSLA-P---GES-GDL 76 
XP_003718197  21 HATEFARDTLVNKEHWCGWVLSNVTVTAEWIFLQYILgLEM-SNEDRRGFLKHFTSSQR-PDGSWSLAtQ---TTTgGEL 95 
XP_001269139  32 KATSYAWEII-SNRHWCGELESNVTVTCEHIFFLYVLyQHI-DPDEGSQYRQWLLSQQN-ADGSWGIA-P---NYP-GDV 103
CAK45506      30 LATEYALSSIRSDGHWCGELRSNVTITAEYIFLRHALgLDL--RTDNAAYCRYILSQQN-CDGSWGLA-P---EYP-GDV 101
KAF3011782    24 LSNDYALGLVHPDGHWYGEMNTNVTVTAEYIFLRQALrLDL--KTDIAAYCHYLLSQQN-SDGSWGLA-P---EYP-GDV 95 
Q2U3C4        28 RSMDYAYNVVRSDGHWCGEMSSNVTITAEYIFLRQALgLDL--KTDGAAYCRHILSQQN-SDGSWGLA-P---EYP-GDV 99  Aspergillus oryzae
WP_015892062  38 RIQAFLLQRQQEDGTWRFCLESSPMTDSHMIILLRTLgIHD--ERLMEKLTAHITALQH-DNGAWKLY-P---DEQeGHL 110 Brevibacillus b...
WP_022543350  10 RLKQQLLSEQTPDGSWNHPFDTGCMTDIYMIVLLRTLeEED-EEELIKELAKGILSRQG-KDGAWRLF-H---DHHeGSL 83  Bacillus
TDZ15627     118 STTVEAYFGLKLLG-TPIESKAMRKARAFTLRNGGVARVGVLTQLVLALFGIVAWKDMAQVPAELMALPAGLsPVNIYSF 196
WP_012098896  93 STTAEAYLALRLLG-LDREDERLRAAERFIRGAGGLARVRVFTRINLALFGLFPWEAVPTVPAELIFLPRWA-PVNVYRL 170 Anaeromyxobacte...
1_pfamImport  77 SISVEGYFALKLLG-VSSDDKAMRLAKEFILSRGGLPLVGIITQFLLAVFGLIKWDQIAQVPAELMLMPTWS-PVNIYAF 154
XP_003718197  96 SCTIEAYLALKILG-VSPEEDYMVRARDYVRSHGGAEKMRMLSRFHLAMFGLIPWAAVPQMPPELIFMPSWS-LVNIYKF 173
XP_001269139 104 STSAEAYLALRIIG-MSPDSPELFQARTFIRAAGGLSKMRMFTRIFFAEFGLVPWTAIPQLPAEFILVPAHF-PISIYRL 181
CAK45506     102 STTTEAYLALKLLG-TSPDMPAMQQARAFVRKAGGAEKVRVFTRIFLATFGLFPWDAVPQLPVELILLPSSC-PINMYTL 179
KAF3011782    96 STSTEAYLALKILG-TSPHTPAMRNARAFVLKAGGIARVRIFTRIFLATFGLFPWSAVPELPVELMLLPSIC-PINIYKF 173
Q2U3C4       100 STTTEAYLALKMLG-LSTDAPAMQQAKAFVLNAGGVAKVRVFTRIFLATFGLFPWKAVPQLPVELILLPSAC-PINIYKF 177 Aspergillus oryzae
WP_015892062 111 STTIDSYYALLLSGkYTKNEPRMALARSFILEKGGLTQANMLTKFATALTGQYQWPSHFLVPVEIALLPPSF-PVSFYDF 189 Brevibacillus b...
WP_022543350  84 SLTIEAYYALLYSGyYEKNHPALVKARRVITKGGGLKKAGMYTKIMLALTGQYPWPLLFPVPMEVILLPRSF-PLNMYDI 162 Bacillus
TDZ15627     197 SYWSRVSAVPVMLLKHHQPIFSLsvvgSDgeevlgATFLDEIFVNpLERRLTSI--------PELstlwrEGQLgRLA-- 266
WP_012098896 171 ASWARSTMVPLFVLFHHRPVFAL----PGga---gSDWLDHLWLGpGDKRVPYR---------------------TSVme 222 Anaeromyxobacte...
1_pfamImport 155 AHWSRVTAVAMMVLRHHQPTFPL----PAdlmvpeKSFLQELYPDvTDQRLRFY--------PSVsrlwqAGEYgRCI-- 220
XP_003718197 174 SSWARCNIVGLCMLRVHEPLYAL----PNgkq-ldNDYLDELWLDpYHKAIPYT---------------------VPYlq 227
XP_001269139 182 ASWARSNVVPLLIIAHHRPLYPL----PNglh-kqNPFLDELWLDpATKPLPYG---------------------Sldpt 235
CAK45506     180 ASWARGTIAPLLIICHHQPVYAL----P-------EDYLDELWLDpTDKNVPYG---------------------SSLrd 227
KAF3011782   174 ASWARGTIAPLLIICHHQPVYSL----PNgks-tdNDYLDELWVDcTNKSVPYG---------------------LPLwd 227
Q2U3C4       178 ASWARGTIAPLLIICHHQPVYAL----PNgvf-aeNEYLDELWQDsTNKSEPYS---------------------PSIwe 231 Aspergillus oryzae
WP_015892062 190 VGYARVHLAPMMIVADRNYVKKP----DN------APDLSDLYAD-TPISRGLYphrflenfLKEg--------qS-F-- 247 Brevibacillus b...
WP_022543350 163 SVFGRSNLIPVILLGNKKFSRKTal-sP---------DLGDLSVRdd-------------ddPWPelrsaEWRSlTSF-- 217 Bacillus
TDZ15627     267 ------------CTIIDKAASVVEpLL----KRSMLRKHCLDQCVQYIVNHLD-AGGFGSLTISNFLCVVGLHASGFPAS 329
WP_012098896 223 tvrrhgpgwkafFNAADAWLRVHD-RLrhlpPLGRLRTEALRACEEWILARQEaSGDWAGIFPPMLNGVLALHVAGHGLD 301 Anaeromyxobacte...
1_pfamImport 221 ------------AALADKAVALMDpIV----KKTSLRAYSLSQCVQFMIKRQT-ESGYASFWPANFNCILALYCQGYEFK 283
XP_003718197 228 lmqt--splgvlFQLGDLFLWLLS-FL----GFWFLRRWAVSSSIQWTLDHQEpSGDWGGIYPPMHHNILALMLEGWSQD 300
XP_001269139 236 d------plsfvFTILDKALSYLGgLR----RCP-TRGYARRRCIQWILQHQEkAGDWAGIIPPMHAGIKALWLEGYKLH 304
CAK45506     228 llsrg-ditglaFSVVDNLLYYLNgLR----SVPLLRSYARRKCIQWILERQEpTGDWAGIFPPMHASIYAFVLEGYELN 302
KAF3011782   228 lmsqg-efaglaFGVLDKVLYQLNgLR----SIPLIRAYARKQCIQWILERQEkTGDWAGIFPPMHANMYAFALEGYKLD 302
Q2U3C4       232 llsqg-ditgltFSLLDKLLYQLNgLR----SIPLLRSYALKQCMKWILERQEpTGDWAGIFPPMHASVYAFVLEGYKLE 306 Aspergillus oryzae
WP_015892062 248 ------------LATIHDSLQQLPf------LPGQLHKLALRRLEQYILARIEpDGTLYNYSTSTFFMIFALLARGFSPK 309 Brevibacillus b...
WP_022543350 218 ------------LAAGVKALVG---------IPRQIRAWSIEKAREYMQSHTEpDGTLYNYFSSTFYMIFALLALGGGPE 276 Bacillus
TDZ15627     330 HPVMGHLTRAMQDALWEDDD 349
WP_012098896 302 AAPVRRGLEAIERFAVSDRE 321 Anaeromyxobacter sp. Fw109-5
1_pfamImport 284 DPAIKCLLHAIDSFYIWKDE 303
XP_003718197 301 DPVIQRGIGACQRFLAEDPA 320
XP_001269139 305 DEPIQLGLAAIERFTWTDNR 324
CAK45506     303 DPPVRLGIQALENFAWEDEK 322
KAF3011782   303 DDPVRLGFQALERFAWEDEK 322
Q2U3C4       307 DPPVRLGIEALENFAWEDAK 326 Aspergillus oryzae
WP_015892062 310 DPLIQKAMQGLTGSVYDYEN 329 Brevibacillus brevis
WP_022543350 277 EPAIRNAVAGLKRMTVKADg 296 Bacillus
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