Conserved Protein Domain Family
SCIFF

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pfam13165: SCIFF (This model is not part of the current CDD release)
Six-cysteine peptide SCIFF
Members of this protein family are essentially universal in the class Clostidia and therefore highly abundant in the human gut microbiome. This short peptide is designated SCIFF, for Six Cysteines in Forty-Five residues. It is a presumed ribosomal natural product precursor, always found associated with a yet-uncharacterised radical SAM protein that resembles other peptide modification radical SAM enzymes and is designated SCIFF radical SAM maturase.
Statistics
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PSSM-Id: 520594
Aligned: 34 rows
Threshold Bit Score: 49.2636
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013276159   2 KHIKVIHRGDLchEDALRKSGCGECQASCQSACKTSCTVANQVCQ 46  Thermosediminibacter oceani
WP_012303268   3 KHIRTVNKRAL---GQRKTVACGECQTSCQSACKTSCTVGNQFCL 44  Candidatus Desulforudis audaxviator
7_pfamImport   1 KHIQTVVKANL--SETLKTGGCGECQTSCQSACKTSCTVGNQVCV 43 
WP_013381915   2 KHITIVKKGTL---ADVKNKGCGECQTSCQSACKTSCTVGNQQCK 43  Eubacterium
WP_013176474   3 KHIRTVVKPSL--RKDLKETNCRECQTSCQSACKTSCTVGNQVCK 45  Syntrophothermus lipocalidus
6_pfamImport   1 KHVRTVVAGSL--RKPRLERGCGECQVSCQSACKTSCTVGNQACS 43 
12_pfamImport  1 KHIVTINKSSL--QDSIKFEGCSECQTSCQSACKTSCTIGNLICT 43 
WP_012813483   3 RHIVTINKKTL--HSTISGRGCGECQTSCQSACKTSCTVGNQVCK 45  Desulfofarcimen acetoxidans
3_pfamImport   1 KHIVTVQKGAL--QATAQTGGCGECQTSCQSACKTSCTVGNQVCQ 43 
WP_059077334   3 KHIITINTESI--QKTAQHAGCSECQTSCQSACKTSCTVGNQVCT 45  Veillonellaceae
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