Conserved Protein Domain Family
pPIWI_RE_X
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pfam13111: pPIWI_RE_X 
pPIWI_RE module N-terminal domain
Domain observed N-terminal to the pPIWI_RE domain module. PIWI/Argonaute modules are typically N-terminally fused to the PTND1 and PTND2 domains, pPIWI_RE_X may represent an ancestral version of these domains or represent a N-terminal innovation predating the emergence of PTND1 and PTND2.
Links
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Statistics
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PSSM-Id: 493133
Aligned: 30 rows
Threshold Bit Score: 157.991
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_049714349    9 AYALSPDAe-pWTDDYRALPRPDVWHDGPLQLCNYG-R--EESQH--LKSAPTRRFDGILQTLAPDLIVRPRPGHGa--- 79   Streptomyces ...
WP_027844734   35 VFTIPQSLa-pVEIKGSTICWTKEALAEFSLMNS---------EIknIKNLPYSSLRSFLEFKLSNVRTIEPSMGLsrya 104  Mastigocoleus...
WP_012163488   20 AFTVPDDLp-pIHASGVTLVWTRQALKSFSDIHKa-----AYGEEekYKELPYQSLRGLLNVLVKEIDRIENHLCLkstl 93   Acaryochloris...
1_pfamImport    1 SFAPVPDT----KTTVHVVGLPDSLRDALFTLMPPR----KEGGY-----LNTKVLKDDLRCWLDRAVELNPVRPNv--- 64  
WP_052482148   65 GYVYLDKYl------eYLVSLEPISDDTLRHVFSCIiGygAGLSTdqTVLLEPPPLAQGVAATPQQTVEMTRFLTPr--- 135  Streptomyces ...
WP_015662314  158 AYLCTPQLl--dGATVVVREFDNGFKHLWRGFDR-AyKdlAGREE---VQAPHSIVTTALRCLTGGYVHFDPWAGVl--- 228  Streptomyces ...
WP_009330232   14 SFPMDER----LLGEVHVYPLPEQFPSAWNRLPKp-----QGKDA----MQPIASLQTAARAVTGERLVFTDPNRPs--- 77   Streptomyces ...
WP_003955311    6 AYRIPRENladLLGTVTAYPLTKEFAAVWGDLPRTGrR----------SRQPYSALSTGLVTATGQPVRLFGEEDLd--- 72   Streptomyces ...
WP_015099491    6 AFRVPAKYldeIFGAVTAYPLTEEFSEAWSAMPRt----eRGWGP------PYASLARGLTSATGRPVTLFDEYDLd--- 72   Saccharothrix...
WP_021802263    9 SFVLDEDSi--dNVELFAFKLPNEVNDIIYKMQDGReK---------NESSSYKTIYKIASTLFDKVIYCNNRFWDik-- 75   Clostridium i...

WP_049714349   80 -------LNGEtpg-ghWLYAP-Wdv-pdPLPGTVLSQLLNAWLRTLgpkdaakdpGFRALMMRVSEEL-KEAAPTWeHV 148  Streptomyces ...
WP_027844734  105 ---inqrKQQN--------FAY-IdsgelQQTTKVLKPILHDWLEIYlayf-aqkeGISEDIIERLRELqEQNKLLSiKL 171  Mastigocoleus...
WP_012163488   94 ireirssNPQN------YDFARlIdsdndEELSKRLRLVLNNWITNDlrpf-cekkDIPEKLLEQIRELaEKGNLIHsRP 166  Acaryochloris...
1_pfamImport   65 -------HTDS------WLIAL-A-----PIDLAKLCNVIAVWISSR------------KDIDTQSPAY-RKVMGML-HP 111 
WP_052482148  136 ------eGRQP--------KCP-------------------NWMYVA----------VPWVISKMLAE----------KP 162  Streptomyces ...
WP_015662314  229 -------------------VTR-V-----EIDNDTLRDAFTLMVGMA----------MGTPIDQISLNNpDPLAVKVaNT 273  Streptomyces ...
WP_009330232   78 -------FTGP------WARRT-LlitpgPLDPIVLGNLVREWEARI----------PGHERRDTLAPMlEPQDg---GP 130  Streptomyces ...
WP_003955311   73 -------DGERatgsrmLLLTT-D-----NALDYRLRVAVRAWERHI---------RKGEGTAELADFLpEPDI----ER 126  Streptomyces ...
WP_015099491   73 -------ETERasgnrmLLLTD-D-----GAMDYRMRIATNAWERYV----------RGGADVSTLAPLlPEPE----RA 125  Saccharothrix...
WP_021802263   76 ------sDDYR------WVYTL-E-----KLELDVIRLKITEWLKKE-----------IELRCETPIEInFKED--W-KF 123  Clostridium i...

WP_049714349  149 ADL-DLLGAgl-pPGRGGTAAP--RPWQFQLATDALARRIlALEPYEFEg--gS---LRFRAVPRgprEQGAELMSQPLS 219  Streptomyces ...
WP_027844734  172 FKS-QIYPWs--qYEESGTARP--YRYSFPALADHLARLI-AGHEIFQGlg----giKRIISSKV---GSSVELITDIIS 238  Mastigocoleus...
WP_012163488  167 FEM-TLLPWp--wQQKTGTTKAd-HGRAYTLVVDYIARLI-AGQEIFKG----CgpmRRVISSYGkfmSSTAELVTTPIS 237  Acaryochloris...
1_pfamImport  112 ETF-EEAVRgeeiCLFSGDGRPa-GGLTFPAFSAQVADVI-AGIPLELA----NgmvENFSRVSRg-nGNVYELISDIHW 183 
WP_052482148  163 FTLyDLLPIitkvPAKEKDGSPklDEHGEQVYKNRTSGW--KANPNRRT--------VTYVP------DSRGGLLAWDHP 226  Streptomyces ...
WP_015662314  274 PQE-HRLLAdyliTNENGQPDA--PGWVYRTVTWDLSIRL-TARPWKV-----DgqeITLRP------DSEGGLIAWGHP 338  Streptomyces ...
WP_009330232  131 YALsEVLQR------DQGRIIG--PYWAFRVAGWKLANLL-AAQPMHIDd--qLpgpLPFLL------DSEGDLLAWESP 193  Streptomyces ...
WP_003955311  127 SFA-EFMTF-----RPGMVPTA--PNWVFRTAAWQITRQL-AGEPLRVDg---RrspLALRM------DTDGSLLAWDRR 188  Streptomyces ...
WP_015099491  126 RPFsEFIRL-----RDGEVPEA--PNWVFRTGMWRIMRTL-GEHPLVID----GrepLQLRM------DTSGALVAWKDD 187  Saccharothrix...
WP_021802263  124 ESI-SLKEI----------FRSk-KGSKYKIIPNYYIYKL-SQNEYDFEslqkT---LKFQRVMG---EETTQMMTLPIK 184  Clostridium i...

WP_049714349  220 ------RDI--KRK----QWW-FSITLNVSLHTVPFD-PRPRLHLHWGVRRWATHPrsdtgALNLPYGRATSV-YLQPKI 284  Streptomyces ...
WP_027844734  239 ------LDDkgS----------FSLVVEIELITFPSV-SQPLIKIDIHKRRWLSSI------KEKAFDHNSINgYIFSKH 295  Mastigocoleus...
WP_012163488  238 ------ITNkgR----------FSLVVKLQLVTFPSV-HQPVIEIDVSKRRWLDSL-------EAPDRYRNDI-FGYAFS 292  Acaryochloris...
1_pfamImport  184 ------HKE---DP--------WAFALRFHVETLPVG-RKARLNMDVAVRRFIGKP-----WQDDPFLKHDVNaYVRTE- 239 
WP_052482148  227 fgrkynVRDdgTAVntasEAQyAMSRISVAMKTQPNI-ADPVILLDAHVTRIHSNM---------RFAKSS---YVYQGG 293  Streptomyces ...
WP_015662314  339 ------WSNktGTA------H-AVARIRLSMKTLPNL-SHPVILASSQVTRLKSNL---------AYARKVLVeQADPDL 395  Streptomyces ...
WP_009330232  194 lthektWVDeeSGKrkriVGY-AMERIHIEVEPAPGG-RVLVAHLSARISRVAN-----------HWKGIRNVlVRHSVN 260  Streptomyces ...
WP_003955311  189 ------DLIvnRSG----SAF-SMARVSARLITRAGV-DDAVVCFDAHLSRVSPQG---------HWAKHV--------- 238  Streptomyces ...
WP_015099491  188 ------DLIanRKG----TAF-SMLRVTGRLVTRAGV-EDPVLCFDAHLSRISPKG---------HWSNNV---WIEPVD 243  Saccharothrix...
WP_021802263  185 ------LEKrkYNS--------FSYCIKMIMKD-PIDmPYSVLNVSLSVRIWEDRNiiddkKSYLKGDESTSI-YIYKEN 248  Clostridium i...

WP_049714349  285 PWLp-GAPA--SDRF--ARARLVRDRRRETFD--WMHNdPAGMLRHLSLq--gHFPSP-EALLTSPL---DW--M-GERL 348  Streptomyces ...
WP_027844734  296 HDYtqSVMPeaYRVFnfKLNRRK-NRNTGKWE--WQPDdAFSVLQRELNlp-lNISNA-EQIIQGKA----------STD 360  Mastigocoleus...
WP_012163488  293 PDLp-------GRTF--SFKVVC-CKENKEWS--WKTAkDFGAIRNQLDlgmqAFSGQ-DIVLKKAD-----------YG 348  Acaryochloris...
1_pfamImport  240 -----------GGTL--RVVPYGYDKQKRDLA--WDPA----ALANYEFasgtGLPAV-REYLEDMG---RY-----ARD 291 
WP_052482148  294 DGLp-------VLHT--ELVRNGTVRQVNQRA--LELLaRDAMNLEVLDelarRAADE-QAVIDRAEaddVFasFiTPEP 361  Streptomyces ...
WP_015662314  396 PLIevELDG--RGKI--RQINRMALQILAKLG--MDYTtLSLIQNRAQAeadhDATTQ-DAESGEGE---IReaLpPIGP 465  Streptomyces ...
WP_009330232  261 PGVvlKAPI--RTR---------WEKGPDGFMqaKAVEyVGATAQIVEAcgvgRLPEPpTDLDVLSD------------- 316  Streptomyces ...
WP_003955311  239 -WId-------RGDAgkTVLRLPLLRSLDKQTerWRSDlNPAIVKILEAcqllPLSIP-DTLPDVPD------------- 296  Streptomyces ...
WP_015099491  244 AGLp-------ILHL-----PMQYRKDKELGD--RRVTlHPATATIYEAckldPLDIP-EELPDRP-------------- 294  Saccharothrix...
WP_021802263  249 PYYl-------DKSI--IFNKISIERNNINSFk-FKNTcDEQYCDILDI-------DV-LNILKDTK---KYq---LGSE 304  Clostridium i...

WP_049714349  349 GVRALVVHSTRM-G----THEVGPGLMPHQRSELTEWAEEALPS--------GVVRV-PD--LVRRG-TG----IAAPAN 407  Streptomyces ...
WP_027844734  361 DYQVLLTYRNGLqEk---KYDIDVGVPEKDKLEAFQAIAKILDSk-------GIKPF-DG--YSEVK-FGk--gKSHPKD 424  Mastigocoleus...
WP_012163488  349 GSQLALTHRNGL-E----KHGIDVGVPETDKLEAYVNIEKLVRSi-------GLVPF-TDyeVVKNK-SSg---RQKEKE 411  Acaryochloris...
1_pfamImport  292 GSQPQILSPYAMtAswasKPSVASGASVIDKAMFFEAVAARLKD--------IAEPV-GA--LDSLQlTHlkasIEEPRQ 360 
WP_052482148  362 GITRPLLPKND-------NFAVGTGPGTLHLRLLAEHVKKVLGT--------KAAWVhFD--VEPMT-FEgrptDKQKMS 423  Streptomyces ...
WP_015662314  466 DSKIRPIQGKSY------KFPIGRGVGMHHMRELDRHIRDVF----------GDAATsPD--IHLST-------RGFPRN 520  Streptomyces ...
WP_009330232  317 ---VRGVHRTG-------RHPIDKGVGAMFLAKLEDHATRLF----------EQPPVtYD--ATSIR-ISkpttDFLPYV 373  Streptomyces ...
WP_003955311  297 ------LIRPHMaGs--rFHALGSGPGPRFMLRLHEHIVRMLP---------GLVPLtYE--TDRRI-------KLLNPV 350  Streptomyces ...
WP_015099491  295 GVLRPQRWRSRF-------HSLGSGPGPRLLMRLQEHISAELP---------QLKPLeYP--IDRSI-------KLAPRV 349  Saccharothrix...
WP_021802263  305 EIVALVGKKYTA------GMLTQYGAGIPERNEMLNLLNNSLFNfqlrepiaFLCKG-GN--TKEEK-LTk---NDLSVY 371  Clostridium i...

WP_049714349  408 Rrakpsg----daakkAEQLRAAAARRTALATASR 438  Streptomyces caatingaensis
WP_027844734  425 Itasrtin-tptsfsaILESLENEDVSDFTAKYCD 458  Mastigocoleus testarum
WP_012163488  412 I--------------------KLPTLLSAMLEAQE 426  Acaryochloris marina
1_pfamImport  361 Adwdkd-----pvsarARQEAWGRANRARLARCTG 390 
WP_052482148  424 Pqertlrv--eagellHSIGFPPPADISASVRAQG 456  Streptomyces physcomitrii
WP_015662314  521 D---------------PKNPLPAPAEVTRSLTSMG 540  Streptomyces davaonensis
WP_009330232  374 P----------------------ADKIAPALKNAD 386  Streptomyces ipomoeae
WP_003955311  351 K------------------RYPVGGPPAAGVGSTG 367  Streptomyces clavuligerus
WP_015099491  350 K------------------KYQKGGLPVAAVGASG 366  Saccharothrix espanaensis
WP_021802263  372 GfdkyigdkldknlvkDGYKLHLKNKNVAITIATT 406  Clostridium intestinale
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