7PB8


Conserved Protein Domain Family
CENP-U
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pfam13097: CENP-U (This model is not part of the current CDD release)
CENP-A nucleosome associated complex (NAC) subunit
CENP-U is one of the components that assembles onto the CENP-A-nucleosome associated complex (NAC). The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. FTA4 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 520584
Aligned: 20 rows
Threshold Bit Score: 162.578
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7PB8_U       144 ESDTRRKVKSAEKISTQRHEVIRTT--ASSELSEKPAESVTSKKTGPLSAQPSVEKENLAi--ESQSKTQKKGKISHDKR 219 human
XP_003495519 138 EDNVRRKVGSTERASARQHQTAPAA---SPAPHVKPVKCVTPERTRCHSTQPSVVEETGAv--KRQLKTQKKVRLSPGRK 212
Q8C4M7       138 ADDVRRRVASAEGPRSQQRQAAPAA----PSPPERPAEPVTPRRTRLHSAQLSPVDETPAt--QSQLKTQKKVRPSPGRR 211 house mouse
Q4V8G7       137 EDNVRRSV-SIERPRARKPPAAPAAasSSSSPSERPAEQVTPRKTSF--PQPSAVEETPAa--QSQLKTQKKVRPSPGRR 211 Norway rat
1_pfamImport   1 ESEIRRKVQSPERIGARRCDAVPAG--APSGLPERRPRSERPEAGGGRGSGAPADGGTPA------METQKKETMSRGKR 72 
8_pfamImport   1 YGEEHSQNEALGHVSAPQGQNTDRQsgGKKINFKKSRHSKPSNGDVQKFNTAGAEEEPLKetvQTLNTTQFKAK----KK 76 
XP_005030554  47 LHSTAVDAYGEERSESESISHVSAPqtKNTGRSKQ-MHLKLSENDVDKSNSDDSTDEHLKenmKAPSTAQLQLK---KKK 122
Q2Z1W2        60 LHSTAVDACGEEHSENESSGYVPAPqrTNAERSEK-MLLETPEGDVHEFSQSGSVREPLMenlNAPNTTRSEVK----KK 134 chicken
9_pfamImport   1 RTAAGRPAQRQQL--EEEGETASESadEKTSESEEESDSDGARRNRRKLPSSDEEDDEGSvwtPTPMMTKHLTKCLHLGR 78 
XP_011235895 141 EGDIRRKVQLAEKIRTRPHKPVPETpcTSLELPEKPAKSVTPKKIGPRGAKSVVAKEMVTe--PRQSETQ--KKMFCGKR 216

7PB8_U       220 KKSRSKAIGSD--TSDIVHIWCPEGMKTS--DIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKE 295 human
XP_003495519 213 KKSGSEATDSD--ASERMHIWCLEGKRRS--SIMELDVILSVFEKTFLEYKQRIESEPCSQAVNKFYFKIKGQLIRMLKE 288
Q8C4M7       212 KRPRRGHTDTD--GSESMHIWCLEGKRQS--DITELDVILSVFEKTFLEYKQRVESESCNQAINKFYFKMKGELIRMLKE 287 house mouse
Q4V8G7       212 KRPRRGSTHSD--ASESMHILCLEGKRQS--DVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKE 287 Norway rat
1_pfamImport  73 KKTSNEAGGSG--ISDSVHIWCLEGKKKS--DLMELDIVLSACEKAIQEHKERIESKICKEAINKFHCNIK-ELIKMLKE 147
8_pfamImport  77 QSSDENTSDSPvdSPHSVQIWCPKDLKRSprDITELDILLAEVEKIAENYRQSIESNICRKAISDFSSAFKDQITDLIAG 156
XP_005030554 123 QPSEESTPDPSvtSPVSVEVWCPKDLKRSsrDITELDVVLAEFEKITSNYRQSIESGICRKAVNGFCSAFKDQITDLITE 202
Q2Z1W2       135 RPSKKSSSDSSvnSPSSVQLWCPNKLKRSsrDITELDVVLAEFEKIAANYRQSIESKACRKAVSAFCSAFEDQVTDLITE 214 chicken
9_pfamImport  79 KSSSDKTKVAK--ADGGV-----GQKKRAgrGASQLEVVLDAVLDFCQQYGETVESAAVRESVGCFASNVEAQLEEQISS 151
XP_011235895 217 KKSRSEATDSD--TSDSVSIWCLEGKKAS--DITELDVVLSAFEKTILEYKQKVESKICKEAIKKFHSNMKEELIKMLKE 292

7PB8_U       296 SQMLTNLKRKNAKMISDIEKKRQRM 320 human
XP_003495519 289 VQVLKALKRKNTKIISNMEKKRQRL 313
Q8C4M7       288 AQMLKALKMKNTKIIANMEKKRQRL 312 house mouse
Q4V8G7       288 VQMLKALKRKNTKIISNMEKKRQRL 312 Norway rat
1_pfamImport 148 AQMLKNLKRKNAKVIADIKKKRQRL 172
8_pfamImport 157 VQELKNMKKKNAKAITSIKKKRQKL 181
XP_005030554 203 VQELKNMKKKNAKVVADIKKKRQRL 227
Q2Z1W2       215 VQELKNTKKKNAKVVADIKKKRQRL 239 chicken
9_pfamImport 152 LKDFRSLKRENIKVGSLIRRKTQRL 176
XP_011235895 293 VQVSKTLKRKNTKIISDIEKKRQRL 317
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