Conserved Protein Domain Family
FTA2
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pfam13095: FTA2 (This model is not part of the current CDD release)
Kinetochore Sim4 complex subunit FTA2
Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1. The equivalent higher eukaryotic protein is CENP-P. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC.
Links
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Statistics
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PSSM-Id: 520583
Aligned: 34 rows
Threshold Bit Score: 108.546
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_023431159   4 L-KPLPDC-------------QGPKLECFIDDIAtCDFKLVELL--GS---GCHS----QVWKAEINGKVYAIKLFFSFW 60 
XP_003049077  11 LpKELPLC-------------DGPKLGLFQHHGS--RIQWLERLnkDDedeDEDSptegYVFRAKIRNREYAIKVFKFHD 75 
Q2U4S0        24 EaLEVQVTndssitnvdevvrQDPMLKRFVGYKD----DITKPRfiDM---GRQG----FVFRFKYREQDLCLKVFYPY- 91  Aspergillus oryzae
XP_009152245  49 AvVDEAETidel------hdaTAAELGRFVDHQD----KFQNPLllGA---GLHG----VVVLADIKGVKYALKVFKKW- 110
XP_001538465  26 LpMDHPERks----------tSKPQLRRFIHHDK--PINRLGFL--GA---GAES----CVYHIECEGKSYALKLAKHWP 84 
XP_002585338   9 LpMDDPARks----------tSKPMLRRFILHTK--PIKYLHLL--GS---GTEG----VVYRVEIEGKEYAIKVFRNWT 67 
XP_002583954   9 LpMDDPTRks----------tSRPMLRRFIHHTE--PIKFIKYI--GH---GAEG----RVYLIEVLGSQYALKIFSNWT 67 
XP_003043577   4 L-KPLPDV-------------EGPKLEPFGHGMLaDHVEFLELVqlPS----GHG----VVIKIKIDDKCYALKIFFYKG 61 
XP_023428899   8 QkPWLPKD-------------IGPKLHPFDGNLMdPSVIFLKALdvNS----AHG----IVVKARIGRHLYAIKFF---- 62 
XP_003051352   4 L-IPLPLG-------------DGPKLQPFSYNLLsDDVEFLEFL--GHh--GVHG----IIVKTRIRGRIYAIKFFTETE 61 

XP_023431159  61 AHEPNflmdpiddferdlddgyePPEEMSRMSQSTIASLRLHA--TSFYNECRVFGRLKELG-----REDLTVKSYGYLQ 133
XP_003049077  76 PMNDD------------------YFWEPLVGEDISLQTVSYYT--DPFYAECRAYGRIQEAIkkgylKSDIVVPCHGFFF 135
Q2U4S0        92 -----------------------------KAPYNVHKEVEAFI--SPFGCESRAFARLCDLRe----NGHWAVRCHGWMY 136 Aspergillus oryzae
XP_009152245 111 -----------------------------KQPGPVFYRYEDAVrmTPLANECRAFARLNSHNe----NGTWAARCYGWMK 157
XP_001538465  85 Y-------------------------YDTDFPNRIKAHERMLM--APFVREARAFARLDSVGe----NGIWAVKCHGWIK 133
XP_002585338  68 Y--------------------------TG---TKLKGRAQHYT--FPIANEARAFARLDSIGq----NGTWAVKCHGWMK 112
XP_002583954  68 Y--------------------------TS--NIYLRERQKPYT--FPFSHECRAFARLDSLDe----NGTWAVKCHGWIK 113
XP_003043577  62 PEFGWd-----------------DAYDTGPTSTMSREDFDKHF--APFESECRAYGRLKELN-----REHLAVKAHGYVV 117
XP_023428899  63 -----------------------------ITPQEDINTRDIYG--HKGSWSC-SFGRLKEQK-----AESIAVKVYGWVS 105
XP_003051352  62 MSEPEy-----------------SASDYPTIPREKAAEFESHF--TPFYQECRAYGRLKEVN-----CEYLAVKVYGYVS 117

XP_023431159 134 FDL--SDDKVQRHFLpfgNGarkrLAFAGnkeptdedvirylM------QHDDLRIPMTAIVKEWvpsskdpklvrdvae 205
XP_003049077 136 LQEr-DEKVLRGRNIdleADqvd----------------peyQrsspggYRP------RAIVKD---------------- 176
Q2U4S0       137 LTDs-QLQQLRRVcgr------------------------------rvgNDPYWGNARWAIVKD---------------- 169 Aspergillus oryzae
XP_009152245 158 LSDt-QFEVISRVVDshgLSr-------------------------------------WAVVKE---------------- 183
XP_001538465 134 LNDs-QFKELGNKHQifcR---------------------------------------WAIIKD---------------- 157
XP_002585338 113 ISGrqRLKSMREYTC-------------------------------------------WAIVKD---------------- 133
XP_002583954 114 LSDe-QFKPLQRFSGls----------------------------------------rWAIVKD---------------- 136
XP_003043577 118 IPV---TEALTQKLRlleSKyehg---------------------kkisNIVEQATHIMGIVKDWvdrvivd-------- 165
XP_023428899 106 LTT----RQIRRKLAaagAQklngFPPGL----------------------------LYGIVKDWvemtp---------- 143
XP_003051352 118 LKV---DQALERKMRnalLKl-------------------------------------YRIVKDWvepary--------- 148

XP_023431159 206 artywppvRPDREVVKRSIGHLPRLLRNLRELHKSGIVVRDLEWQQYQDGQLVDFSFAW 264
XP_003049077 177 ---------LASADPGVNQDNLYQILRDIVRLNSQRVFNMDIRLDNYRDGKLVDFGSSW 226
Q2U4S0       170 --------FIADKPPSRQDEQFQNILSNFCIPKRGGILPDDVKKENYRGDRIVDLGSTI 220 Aspergillus oryzae
XP_009152245 184 -----------YLPMPTEGCHFDEMRDKLKIPGRLRIYPQDLRLENCRGAKVVDLSSTL 231
XP_001538465 158 -----------MIPDEISMNDIPEVRRKMQIARKALLWPGDVKPENYRGSFIMDLGNTI 205
XP_002585338 134 -----------YLPHPVSISDIPEIRRKMKIARKALIHPSDTQPCNYRDSFFVDLGRVK 181
XP_002583954 137 -----------YIPNEVSISDVPEIRRKMTIARKALLYPKDLQPRNFRGSFLVDLGAVR 184
XP_003043577 166 -pslegdfDQAGGDEICQVRHFPRMLRDLHEFHASGIVIRDLGLWQYINGVLVDLSLAW 223
XP_023428899 144 ---yhdskQRDMYDQMVAVKYFARMLKDLHKLHFLGIVIRDLKPDQYIDGILIDLSLAS 199
XP_003051352 149 --wretdiPSHRIDSILSVSHFPRMLEDLHEIHRCGIVIRDMSISQYVNGVLVDFSMAW 205
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