7XHO


Conserved Protein Domain Family
CENP-Q
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pfam13094: CENP-Q (This model is not part of the current CDD release)
CENP-Q, a CENPA-CAD centromere complex subunit
CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 520582
Aligned: 74 rows
Threshold Bit Score: 59.97
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7XHO_Q       117 LLQQCETLKVPP--------------KKME---DLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSL 179 human
XP_013932243 165 LAKKMRVARFPG--------------EIKErllDQEQLDEENMRLEANFSANLRQLEVLRVQEQKEQALLDSEEKYLEQF 230
XP_006683672 157 FKRRLQTTKLPRrvsihs---tnpqnDENKyvlNHDILNRRKTFLETYLSAELKQLKDLTKTYNKIELNYKSDLEYLKEF 233
XP_036666757  96 FRSRLKVTQLPLsldldvlgnvtndaVEVKnvlSAKELSDKQKMLDAYLIEEIKQLNGIKEHFFKMEQDRIRDHAALKSY 175
Q5A0H0        92 FKSRLSQTKLPPpssmyss-klriraNEVAdvlSYDSLTRKRTVLETYLSAELKQLQELENHYNQSLLAYKSDLEYLKKF 170 Candida albicans
XP_002547026 112 FKARLDQTNLPPpnsmynt-kvrikaNEIKdvlSYDSVSRKKTALETYLSAELKQLQELEDHYNQMLLSHQSDLQYLQKF 190
EMG50891      96 FRSRLQLTKLPPpnsmyvh-hvrnktNDLKnafDYDSVLRKKTVLETYLSAELSSLHELEQTYNQSVLMYDRDVGYFGTF 174
XP_001382869  86 FRSRLEVTKVPApssma-----tnksNEISdilSYDQLSRRKTFLETYLNAELKQLSDLQKHYQGMEVAYQSDLEYLEEF 160
XP_001485277 141 FLSRLKVTKVPLptshs-----krnsSEDMnvlAFDSLNRRKKFLETYLQAELKQVNQLEKYHKELSTVYQQDLQYLQEF 215
XP_002615652 191 FLARLSVTKLPPlkslhv--rmkgseTVNYdplSIDSVLHKKAMCEAYLSAELKQLESLESNFRALQSTYESDSKYLHDF 268

7XHO_Q       180 KNKIQILASE-VEE--EEERVKQMHQINSSGVLSLPELSQK--------TLKaptlQKEILALIPNqnaLLKDLD-ILHN 247 human
XP_013932243 231 KKSVERQEELmAKD------LLPYADLADDLQISEPKSAEHlnlasteyNGYdpatDPDFSESMNT---LDKHLNsISKN 301
XP_006683672 234 NKTVEANESKmSQEvyTKKTTMNLKYSDTSNLDSDVTSSNV---------RFtpreDDEVNELLEK---LDSGLKrVSGN 301
XP_036666757 176 RESVENLLSLmDVQveELQHEMKLGQEVGDEGISLVGYESI--------SDFnpneDSDVSKRLQV---LQSKLSsLLEK 244
Q5A0H0       171 KSTVKNNESKyNEEleRKREELNLSVQNKNPDDIYLLSTDN---------DFdpetDDDTKFILET---IQENL-----F 233 Candida albicans
XP_002547026 191 KQTSKRHQLKlDSDidDIHEELNLIEYDKKPDDIYLQSNST--------YEFdpdqDEDTRAILEQ---LNKSLNi---S 256
EMG50891     175 KGTVKGEERRlDEEiqAMEEELALFEYSKLPDNIYLKKKKMd------mGEFdpdrDDDTKEILVK---LNGSL-----N 240
XP_001382869 161 RKTTASHAKDvNKDitNIRESLGLDARNGSSDNIKLTSKTDt------kSSFnpdeDDATKELLQS---LHSHLQsISSN 231
XP_001485277 216 KKTTEIEIKSmTEEatELRRNMGLENSKNTPEGEYVEKPVK---------PFnpndDPETRQLLTE---IRDKLApLQEK 283
XP_002615652 269 KKTTSSLQAQnAAEksEKMKQLHLDGIPSLTKNVHLEAQPQsg----slSGFspnkDEEVSLLLQN---INKIIDdKREP 341

7XHO_Q       248 SSQMKSMSTFIEEAYKKL 265 human
XP_013932243 302 VELLDPLVDILDRVNSIL 319
XP_006683672 302 SKDLIDFHERLQNFQDSL 319
XP_036666757 245 SASLRSFNDRLESVYNLL 262
Q5A0H0       234 QSKLKNLNDKLEVLCNVL 251 Candida albicans
XP_002547026 257 TSDLKKLNGKLEILSSML 274
EMG50891     241 LMDLKKLNEKLEVMINML 258
XP_001382869 232 TEQLGSLNDKLELVYNIL 249
XP_001485277 284 CKELAEADDALDVLYNFL 301
XP_002615652 342 MRQMLESCDQLDVISSKL 359
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