Conserved Protein Domain Family
FTA4

?
pfam13093: FTA4 
Kinetochore complex Fta4 of Sim4 subunit, or CENP-50
Fission yeast has three kinetochore protein complexes. Two complexes, Sim4 and Ndc80-MIND-Spc7 (NMS), are constitutive components, whereas the third complex, DASH, is transiently associated with kinetochores only in mitosis and is required for precise chromosome segregation. The Sim4 complex functions as a loading dock for the DASH complex. Sim4 consists of a number of different proteins including Ftas 1-7 and Dad1.
Statistics
?
PSSM-Id: 404079
Aligned: 58 rows
Threshold Bit Score: 86.1637
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
EAZ62821               4 YLYTKRFIDQQVKILNQPLVIDDRLRALIAQLQSEYgp--dsISESQLQKVLQKTNARIRRHNAAAFSAQVTNQIVQQVL 81 
XP_006688053           6 YNYIKSFIDAQIREINRPVELSRQVKAVLSDEN---------INIKQFQITLMRLNLLIRRHNSNMFPPRIINQIINQII 76 
Q6BI48                 5 YLYTKRFIDQEVRRLSQPLVVTSKVERILTEESTEDdpdgqqVGEKQLQQIISKVNVLIKRHNRNVFSRQVVNQIIQQVI 84  Debaryo...
XP_004202183           5 YLYIKRFIDREIHRLNEPLRADREFKEALKRVESNGy----eVSDKQVRQALAHINTLIKRHGRNVFAKQVVNQIVQQVV 80 
Q5ANH4                 5 YTYTKNFIQSQVNILNEPYRINSRIRNILAEQDE--------ITESELQTILNLLNNEIKECNDELFPSQINNQIVSQIL 76  Candida...
EER33669               5 YNYTKRFIDDQVNILNEPFKITPRMISVIGGN----------LTEDQLKSILNKINNDLQLHNERLFPAQINNQIISQIM 74 
EGW31598               5 YLYTKRFIDEQVKILNQPLRLTDSLKQILQQQDENAdk---vITEAQLKKVLVKLNTKIRNRNQVIFRAQIVNQIVQQVL 81 
XP_002617569           5 YIEIKKFIDDQIKILNTPLRLDDEMRSIAARHN---------LSEEKVSSLLFKCNLRLKRHYRSAFNKQVVHQIVQQIV 75 
LoveMIT:GQ68_03100T0  11 YLSVHDSIKNQVSIVKKPLIISKDLNEILKTQHQYEpnqakhLSPLALNRLIRSVNFLLKARYASIFNRQAIHLVSLQYI 90 
ESX00058               4 YEELKKVLNHQTKVVSKPLVFDKDVQRFVEQVESEA------VSKTQIVRIINSTNRYLNKRYGQFFHRQSIVQIIQQVL 77 
EAZ62821              82 KLESYKLAI--------VNEQLAKiryilrplllpdfn-------svsnddpktrlrqfELLIKELPESQYlivddspmn 146
XP_006688053          77 KSENYKIEL--------VNERLSRiskiikpliltnl---------npsssslqsvgevNELISELPEAKYlfvthsvgt 139
Q6BI48                85 KCEQNKLMV--------VNEKLMRiemilkpillpev---------nqmgnvktlmgefGELVRELPESKYlfdeddddt 147 Debaryo...
XP_004202183          81 KVEEYKLQA--------VNKRLLQleqivspilipdf---------drignarnriaalGQIVDELPEERYlffksests 143
Q5ANH4                77 KLEKQKLKI--------VNSQLFKinsfikpitlpdfd-------nltnqdqnkklaelREQIKELPDSKYlfvsntdtt 141 Candida...
EER33669              75 KLETQKLKI--------VNQQLYKlnafvkpiilpdfe-------nlsnydqheklidmIGMIDELPESKYlfvsedgit 139
EGW31598              82 KLEQNNLEI--------VNEQLTKihyvlkpilipdfe-------hlsnktqlsklmelGDLIKELPESQYilvrntaee 146
XP_002617569          76 KSENEKLLE--------VNERLSRiqslvqpiilpdf---------qkvgsvkdrvrlaNELAHELPEPAYlfaiydsaa 138
LoveMIT:GQ68_03100T0  91 E-SEKRMEI-------------ERldeflklyyllepfnsqdhsannvhglllvqkehfMDKVHKLPPSST--------- 147
ESX00058              78 N-NEHALDLqrkqkllaLNEILMNfgsdtvvdvngnyeddrgsnnidmngmmrikqeeiLGMIDELPDPDNlta------ 150
EAZ62821             147 kneqrlfvssdeesdsededdn-----------llveddaarveepvssqrlrshytkklkeeVNrQIQRDQTI---DQl 212
XP_006688053         140 hnddpesqpqvededededdvq----------ygdglvedfeetvktpakneklkfqqtlyrqLDqKMGLD------NEl 203
Q6BI48               148 tdedekapdhassdeegi-------------------lvqdeqerveddelkkpqynrrlrqqTEqEQSKSSS----TQl 204 Debaryo...
XP_004202183         144 teqkdekdkpgnddgsagese------------deenaiqetlimsddelvpdaasieqltrhVErQVEQEIYLgdhEQt 211
Q5ANH4               142 diqdeydlddddqgqdmenepreeqaednetdkantdivqddqeevastkqmkkefiqeiadkVNdSNAQPD-----QEl 216 Candida...
EER33669             140 nveddysidedetnnveld----------------dntiqdteeqvesrkqinkefieeiideVNeLNESPE-----PEl 198
EGW31598             147 epdseeesdeasdenili------------------qddqdivekkpsqrkqiaqhrreviqkVQqAENRD------ENl 202
XP_002617569         139 andsrtpetenlrtesglvrdneemvgetpgseipaaseestneasrqndagenveftethqaVLnEISNNAMT---QDl 215
LoveMIT:GQ68_03100T0 148 ---------------------------------------------------------------VAhLLKQRSDI---TPl 161
ESX00058             151 ---------------------------------------------------------------------------qnDEl 155
EAZ62821             213 lAKYDELRLALVDEHSKLSYLFEKIQYLKSLKNEIQNTLGis----lPGENNKKVDHEIYDSDEeedevvggvsqlqsnl 288
XP_006688053         204 lEQYGVVRSRLLETNEQLQYKQSKMKYLELLRRKLADAMGmt----------ieDDRLVVSSVDn--------------- 258
Q6BI48               205 lHKYDDIRHHLIELHQGLEYKYAKLEYLTLLKEKLIRVLLvpe-ehaKRDPFHGQDKMVGNDDEpfdsddeandsls--h 281 Debaryo...
XP_004202183         212 lRNYGQVRQDLIAIHKELQYKCAKLDYLSELRNKLVQNLGvaniaqpQRKTQNGTSDEPVDSDEdfdmeqwaiqs----- 286
Q5ANH4               217 iEKYDKLRTDLIDISDRLQYKSGKLGYLSGLQQTLSEIVGv------RSTTIDTQSNQIYDSDEevstpndnets----- 285 Candida...
EER33669             199 iEKYDKLRMDLIEISKALKYKTDKIEYLNNLQHNINQLFNr------NQPQMRSDSNELYDSDEelheapkvnnlqn-nl 271
EGW31598             203 vERYHDLRANLLKLYESIRYKYDRSNYLKGLKNNIQGSLGi-----sKLKADTHGNDQVYDSDEegegdydingiqt-nl 276
XP_002617569         216 kEKYTRLRAELLQINGELMYKLQKTDYLEKLERKMNFLGPtka-eeyLDSDVEETETISEEKGE---------------- 278
LoveMIT:GQ68_03100T0 162 lASYDKVKENLISKENKVEALKQKLSHYNDILKLLTSS---------LSDPERLQQNLVISSNTe--------------- 217
ESX00058             156 lARYDELRSKLADNRARLLRLQDKKKYYEKTRKLLSEMTDs-----tEDPDSTLQKNLVLNTNDq--------------- 215
EAZ62821             289 vtndhnssargLLSEINRFRVLVEKLSYK 317
XP_006688053         259 ----------sMRSEMSRFKLLVDSIAFk 277
Q6BI48               282 qhsldymtntsLSNEINKFRVLVEKISYR 310 Debaryomyces hansenii
XP_004202183         287 -epvadpttsnIAAEINKFKILVEKIAlk 314
Q5ANH4               286 lqpgpystrtnIQSEINRFRMLVEKISYK 314 Candida albicans
EER33669             272 qfknsatetrnLASEINRFRILVEQISYK 300
EGW31598             277 ittsantnpdnVIAEVNKFRVLTEKLSYK 305
XP_002617569         279 -----------LSAQISRFNILVEKLEfv 296
LoveMIT:GQ68_03100T0 218 -----------LTAQINQLRILLSRLEYK 235
ESX00058             216 -----------LVNEVSQTRIQLAMINer 233
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap