Conserved Protein Domain Family
CENP-L
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pfam13092: CENP-L (This model is not part of the current CDD release)
Centromere protein L
CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-L forms a channel with CENP-N through which a DNA duplex threads.
Links
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Statistics
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PSSM-Id: 520580
Aligned: 54 rows
Threshold Bit Score: 145.926
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q2GZ13         53 PFYNTTFSVHRLSSLYLgaepLTP---SRLQLLAQRLRDSLVGDVIRGVhvgta-----------asaaAGDDEGgsvvg 118 Chaetomium glo...
XP_015211334   80 LLMKKEWKLFYVTPLYK----FKH---TQLKTYSKQLSAFIASEKQKGRavevgpetgf-kvvfsiifgLTETEE----- 146
1_pfamImport    1 LLLDGEWKLSYVTPLFL----FRH---TQLKLYSKRLAAFIIAEKQQGVavevgleagf-rvsfsavlgMAETEE----- 67 
9_pfamImport    1 LLVKTEWQLSYVTPLYQ----FRH---TQLRSYSRQLSAFITAEKQQGLavevegaqtsfrvsfsavqgLGETDD----- 68 
10_pfamImport   1 LLVKTEWQLSYVTPLYQ----FRH---TQLKSYSRQLSAFIAAEKQEGLavevgglqntfkvsfsvlqgLAETSD----- 68 
6_pfamImport    1 LLVKAEWQLSYVTPLYQ----FRH---TQLRSYSRQLAAFIVAEKQQGLavevselhnsyrvslsvvqgLTESED----- 68 
8_pfamImport    1 LLMKTEWQLSYVTPLYQ----FRH---TQLKNYSRQLAAFIAAERQQGLavevegphgsfkvsicvlqgMVVTDD----- 68 
EFX84777       61 DLKQKMWSVYRLSDLNS----FDNtkpTTFPRYERILSRYLVNSFTQAVtlqa---------------kfkLKHDi---- 117
XP_001605964   57 ELLRQTWNIWGVSVLFD----FHCdneVQLKQYAKKLREEVACILSQDDvsyeak--------isvldiQRPKET----- 119
Q1T7C0         66 FLLRKQWTLYSVSPLYK----FSS---ADLKDYARMLGVFIAAEKQKGLavdvdgelgi-kvamsglpeLRGSEQ----- 132 chicken

Q2GZ13        119 raGalervdvawvrvgdvlgfeggegegggsgegedgegwrqlvrglQGKKALHIS-----LQY----------EMASCT 183 Chaetomium glo...
XP_015211334  147 ------------------------------------------------DTELVFIQ-----IHSkpsfaaegasDVVIWS 173
1_pfamImport   68 ------------------------------------------------DAET---------ISSrpvf--gadgSKPVWQ 88 
9_pfamImport   69 ------------------------------------------------DAETVLLQ-----IHSkpvfagkdeaQKLVWS 95 
10_pfamImport  69 ------------------------------------------------DPETVLIQ-----VQSkpmfarqedpPKTVWC 95 
6_pfamImport   69 ------------------------------------------------DAETVLIQ-----IHSkpmfarqdepQRSVWS 95 
8_pfamImport   69 ------------------------------------------------DAETVLIQ-----VQSrpvfakpdepQKPVWS 95 
EFX84777      118 -qGf------------------------------------------dQEDLPVHIKvedvqLSQ----------PRLVYE 144
XP_001605964  120 ------------------------------------------------DHPVVKIEvh-arLTGre------dkESCVYK 144
Q1T7C0        133 ------------------------------------------------DPAAVLVQ-----LSLrssvspknseEKLIWS 159 chicken

Q2GZ13        184 AL---------LLPpl-aGdgengldkpemrfsvgggqsrgdednmdwEHSADPSHFLSLPLLLVRMPPPLKAIVGEFLS 253 Chaetomium glo...
XP_015211334  174 GWlacingnteYLRaipaD-------------------------------------FVCLPLFCASGAGSLTSLVKSWFE 216
1_pfamImport   89 GWltcvngdpeYLRslppD-------------------------------------FTSLPLFCSRGAESLSALVKSWFQ 131
9_pfamImport   96 GWltcingnpeYLHllpkD-------------------------------------FTCLPLFGSRGAENLTSLVKSWFQ 138
10_pfamImport  96 GWlscingnpeYLQslpkD-------------------------------------FTCLPLFCSKGAEDLSSLVKSWLQ 138
6_pfamImport   96 GWltcvhgspeYLRslpkD-------------------------------------FTCLPLFGSRGPEYLSRVVKSWFQ 138
8_pfamImport   96 GWlsciggnaeYLRslpeD-------------------------------------FTCLPLFCSHGPEGLTSAIKSWFQ 138
EFX84777      145 GL---------LLSar-------------------------------kSGGSKTDGVVHLPVLLARGPRAVREKVHDCLS 184
XP_001605964  145 GY---------LLSwrs----------------------------htlTDVPTENS-SRLPLLLCRGTPKTMRAVHATLT 186
Q1T7C0        160 GWfccv-agddLLEnlpeN-------------------------------------FTCLPLFLVNGAESYTAIVGSWFQ 201 chicken

Q2GZ13        254 TTFDCRVSPMRLGTRSLMGIWEAWI-----------KSAGMpsrgSLARDLVLTLGFHvPPpeptpapskeevtaeqhpP 322 Chaetomium glo...
XP_015211334  217 TTFDCNFGQLRISPSNLHRLATMWTgc-------hpTVNIR----------YLKLSWTlPT------------------C 261
1_pfamImport  132 RTFDCSFGALGLSSSTLHWLAALWTgc-------hpAAGIR----------YLKLGWTmPT------------------Q 176
9_pfamImport  139 QTFDCCFGPLEINQTCLQWLAALWTnc-------hiESSIQ----------HLKMIWTlPV------------------E 183
10_pfamImport 139 RTFDCCFGPLDINQTTLQWLAALWTnc-------hmETNIQ----------NLKMIWTlPV------------------L 183
6_pfamImport  139 KTFDCCFGSLEINHTSLQWFAALWTdc-------hsQSHIQ----------HLRMLWTiPA------------------A 183
8_pfamImport  139 RNFDCSFGPLELSHVSLQWLMALWTnc-------haESGIQ----------HLKMIWSvPV------------------A 183
EFX84777      185 AVFSSSIHEVSFPAEDMHWMIAAWSgf----------------inESRNNKEVSFMYGiPSr------------------ 230
XP_001605964  187 RMFDCMFVGLPANAEDLMWLLPIIIspgggqdtardSDEAL-------------LEYGvPG------------------L 235
Q1T7C0        202 KTFDCCFRRLAISPLNLTWMAAMWTgc-------kvDKNTA----------ATELLFSvPH------------------L 246 chicken

Q2GZ13        323 LGLKSIDVIIPAAALPRFVDVGERAAttqgkqatsparwgwegdlrkrrrlagrlyeegwewrgesrenggspspqpFTE 402 Chaetomium glo...
XP_015211334  262 PP-LDISYTVNPGDVSDLWSRICQGKdqvss-----------------------------------------evakqFFQ 299
1_pfamImport  177 PP-LDIEYSVDPQDAWELWNSVHKedgaderi--------------------------------------svdevqsFIN 217
9_pfamImport  184 PP-LQITYTVNSQDVWELWNSVRNPSlesreeeeaa-------------------------------rsidieevtrFMQ 231
10_pfamImport 184 PP-LQVTYTVDSDDVLDLWRSTRESSaeksreaede-------------------------------vcidfsevtrFMQ 231
6_pfamImport  184 PP-LQITYTVDHQDAWDLWNSVRKGPtaavaedaa---------------------------------sidleevtgFLQ 229
8_pfamImport  184 PP-LQVTYMVDPQDAWALWDSLRNSQrhsknalgele-----------------------------ednidleevmmFIQ 233
EFX84777      231 --tDTIQCQYSVNFIKDLWSCIHDKDnpvvel----------------------------------------sevkrFYS 268
XP_001605964  236 PNSESITIKFHVKNLTTLWKSFLDDKdkida-----------------------------------------eevekFHK 274
Q1T7C0        247 PQPLDISYAIHPEDAKALWDTVQKTPgeitq-----------------------------------------eevdvFME 285 chicken

Q2GZ13        403 ALAYYVKEHLALNLFhpGVRVIKIACGGFAMSE-SRLKLfapsgsgagedeglplLAHKGAVLELLGSLVGKAQ 475 Chaetomium globosum ...
XP_015211334  300 CLESHFFRHFRIHLS--AGELTKVSTALGSAYRdGKIQF-----------------MNSDYMIDVLMLLTESAL 354
1_pfamImport  218 GLETHFFRHFKIYLS--SGTLTKVSTALGSAHHhGKIKVi---------------TINSDYISTVLTLLTECAL 274
9_pfamImport  232 GLKSHFYRHFRLDLS--AGRLSQVSSALGSAKFsGRIKM-----------------SNSRYVLTTLTLLTECAL 286
10_pfamImport 232 GLMSHFYRHFRVDLS--AGELNQVSSALGSAKVnGKIKI-----------------SSSRYLISIFSLLTECAL 286
6_pfamImport  230 ALKSHFYRHFRLDLS--AGTLQQVSTAVGSAKSsGRIKM-----------------SNSRHVIATLTLLTECAL 284
8_pfamImport  234 ELKSHFYRHFRVDLS--AGSLNQVSTALGSAKCnGRIKI-----------------SNSRYMITTLMLLTECAL 288
EFX84777      269 SLIKHTKNTIGLNLA--AVPLIMYKTPDFELHTvGKVKV-----------------STLEFIPRILHFIADLCD 323
XP_001605964  275 VLQRQVMEISNVQLG--LCMLHRIHLPCLTISG-SKMKV-----------------MNVEAMDTILTYLNEKAL 328
Q1T7C0        286 CLYSHFHRHFKIHLS--ATKLVKVSTGIASAHCdGIIKF-----------------LQSQYLIGVLMLLTELAI 340 chicken
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