4A4A


Conserved Protein Domain Family
NAGLU_C

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pfam12972: NAGLU_C (This model is not part of the current CDD release)
Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This C-terminal domain has an all alpha helical fold.
Statistics
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PSSM-Id: 520549
Aligned: 119 rows
Threshold Bit Score: 165.879
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4A4A_A       626 WTEDYIERRYG-KTNKEILEAWNIILDTAYkKRND-YYQGaAESIINARPGFGiksastwghskivYDKSEFEKAIEIFA 703 Clostridium per...
CCY34524     466 WLQGYVKARYG-RITPEVLQAWRLLARSIYeCPAAsTQQGtHESIFCARPSLNtyqasswsemsdyYDPADVILAANLMV 544
CCY16788     443 WLAAYVTARYG-RSVPAAHEAWRLLRHSVYeCPAAsTQQGtHESIFCARPAADayqvsswsdmrdyYDPADVIHAAGLLL 521
CDB04643     455 WLSRYVQTRYGnVTNPKVSEAWLLLARSIYgCPADnVSQGcRESVFCARPSLDakwvsswaetvdyYEPDSVIRAARLMV 534
WP_022054582 451 WLKDYLFARYG-VRDEKITQAWSILADGIYnCPFGnNQQGpHESIFCGRPGLNnfqasswskmqnyYDPTSTEAAARLML 529 Phocaeicola ple...
4_pfamImport   1 WVKNYVKARYG-VEDEAIEKAWLTLAKSIYnCPAGnNQQGpHESIFCGRPTLNnfqasswskmknyYDPAMTKKAAKLMN 79 
CDD20256     467 WIKEYCFARYG-VHDKTIEEAWTILAQSIYnCPLGnNQQGpHEPIFCGRPSLTnfqvkswskmhnyYDPEDTRRAAILMA 545
EGQ13735     480 WVRGYVKARYG-TDDPHAQQAWQLLAETIYnCPAGnNQQGpHESIFDGRPSLNnfqvkswskmrnyYEPSATLEAARLMA 558
WP_021987418 446 WVEGYVKARYG-CDDSRLRQVWQILSETVYnCPDI--REGtVESVFCARPAEEvhsasswgssrmyYPPEESEKAAKLML 522 Culturomica mas...
Q89ZL8       466 WLQAYLKARYGnDLSPEVAEAWRALEHTVYnAPKNyQGEGtVESLLCARPGFHqdrtstwgyaklfYSPDSTAKAARLLL 545 Bacteroides the...
4A4A_A       704 KNYDEFKDSDAFLYDFADILKQLLANSAQEYYEVMCNAYNNGNGEKFKFVSGKFLELIKLQERVLSTRPEFLIGNWIEDA 783 Clostridium per...
CCY34524     545 QAAPDFAGCDNFEYDLVDILRQAIAEKGRLTYKAIQQAYTSRDTAALRSHGENFLTLLLLQDSLLSSRREFMAGNWIAQA 624
CCY16788     522 DAADELRGSDNYAYDLVDVMRQAVAEKGRLVHAAMRAAVEADDVERFDREASRFLSLILVQDSLLVTRPEFRVGTWIGRA 601
CDB04643     535 EAAADMPANANFRYDLVDITRQAVAERARLVYNEIVAAYKAHDRKMFHHTTQRFLRLLLQQDRLLSSVPDFMVGRWIKQA 614
WP_022054582 530 EVADKYKGNNNFEYDLVDIVRQSLSDRGRIVYNQTIADFKSFDKKNFAAHSQEFLNILLAQDRLLGTRSEFRVGRWIEQA 609 Phocaeicola ple...
4_pfamImport  80 SVAEKYRGNNNFEYDLVDITRQALADQARLQYQKTIADYKAFSRKQFDRDAERFLKMLLLQDKLLGTRTEFRVGHWTQDA 159
CDD20256     546 SVADKYRGNNNFEYDLVDICRQALDDQGRRQYLKTIADYNAFAHKDFDKDAKRFLDMLLLQDKLLGTRSEFRLGHWTEAA 625
EGQ13735     559 AAADRLKGNNNYEYDLVDIVRQAIDDQARQVYLHAIADYNGFDRRAFSRDSARFLGLLLMQDRLLGTRREFRLGRWTEAA 638
WP_021987418 523 SVADRYAGNNNFEYDLVDVVRQAIADRGNRLQKEVTAAYRAGKKADFQRLSREFLDLILVQDSLLTTRREFKVGNWIAQA 602 Culturomica mas...
Q89ZL8       546 SVADQYKGNNNFEYDLVDVVRQSLADKGNVLLEEISQSYDRKDKDSFGKQSQQFLELILAQDSLLSTRKEFSVSSWLNAA 625 Bacteroides the...
4A4A_A       784 RTMLKDsdDwtKDLFEFNARALVTTW----GSRnnadgGGLKDYSNRQWSGLTEDYYYARWEKWINGLQ----------- 848 Clostridium per...
CCY34524     625 RALGEDeaM--KDWLEWNARVQITTWgnrtASDt----GGLHDYAHKEWSGLLADFYHVRWKTWLDRLL----------- 687
CCY16788     602 RQCGQTpeE--QAHYEWNARTLITTWggraAADr----GGLHDYAHREWNGLLRDFYYRRWKLWIDGTS----------- 664
CDB04643     615 RSIATTkaE--ADHYEWNARTQITVWgnrqAAEq----GGLREYAHKEWSGVLRDFYYPRWRMYFDALD----------- 677
WP_022054582 610 RNLGTTpeE--KNLYEWNARVQITTWgnrvCANd----GGLRDYAHKEWNGLLKDFYYKRWAAYWQTLQ----------- 672 Phocaeicola ple...
4_pfamImport 160 VNAGNTaeE--KKLYEWNARVQITTWgnryCADt----GGLRDYAHKEWQGLLKDFYYVRWKSYFDALAaqmkaqtapqp 233
CDD20256     626 RNLGKTpaE--KDLYEWNARVQITTWgnrtCADk----GGLRDYAHKEWQGLLKDFYYKRWSSYMKALAdqmeastkpdy 699
EGQ13735     639 RSLGTTpaE--KDLYEWNARVQITTWgnraCADq----GGLRDYAHKEWQGLLADFYYMRWHTYLDALSrqmarnalpdp 712
WP_021987418 603 RKIGRTedE--KRLYEWNARVQITTWgnrkAADe----GGLRDYSHREWSGLLKDFYYPRWKAYFDMLG----------- 665 Culturomica mas...
Q89ZL8       626 RSLGTTeeE--KKLYEWNASALITVWgdsiAANr----GGLHDYSHREWSGILKDLYYQRWKTFFEQKQ----------- 688 Bacteroides the...
4A4A_A       849 AELDGGakap---------------nidWFKMEYDWVNKKsdtdKLYPTEASnEN--LGELAK 894 Clostridium perfringens
CCY34524     688 ADPTGPdpal---------------sidYYSLEEPWTLRK----NTYPSKPT-SS--PIPTAI 728
CCY16788     665 QALRHGdplp---------------sidWYAVEEPWTRDT----SPYASTPE-GD--PIDAAR 705
CDB04643     678 QTFDGKpmp----------------qfdFYAIDEAWTRRH----NPYPSEAQ-GD--AVEFAR 717
WP_022054582 673 DVLDGKpmv----------------eldYYAMEEPWTLAH----NPYASQPE-GD--CVSVAK 712 Phocaeicola plebeius
4_pfamImport 234 ELLGGGpnatktaaelfamalpqevkldYYAMEEPWTLDQ----TPYSAAPE-GS--PVDVAK 289
CDD20256     700 EALGGGknanktaselfqmalpsgpqidWYAIEEPWTLQH----NTYSSKPE-GS--SVDVAK 755
EGQ13735     713 DALGGGpnatktsselfalampagpqidWYALEEPWTLRH----NTYSPQPV-GS--PIDMAH 768
WP_021987418 666 QRLNGVqvq----------------didWYAMEEPWTWLR----NDYPAEPE-EN--AVEVAQ 705 Culturomica massiliensis
Q89ZL8       689 RELDGKldqsa------------eepinFYGMEKAWAEKN----KtADSSDH-KSqtVIETAK 734 Bacteroides thetaiotaomicron
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