2VC9


Conserved Protein Domain Family
NAGLU_N

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pfam12971: NAGLU_N (This model is not part of the current CDD release)
Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain
Alpha-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation of heparan sulfate. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations. The structure shows that the enzyme is composed of three domains. This N-terminal domain has an alpha-beta fold.
Statistics
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PSSM-Id: 520548
Aligned: 116 rows
Threshold Bit Score: 65.2347
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2VC9_A       172 NEIKNLVGRVIGReFKDKFIFEIr----dQLNGNDVFEVSdS-------GDG--KVLIKGNNGVSLASGFNYYLKNYCNV 238 Clostridium per...
8_pfamImport   1 AGIEALVRRRLPQ-HEHSFTFSLsa---nKESGLESYAVT-T-------THDg-KFRVEGTSLSSILYGLHSYLFDVVHV 67 
XP_013938974  26 AGVESLVKRRLPN-HAKSFEFALespshgSTLTNDSYTVS-S-------TRDg-KIRIEGTTTSALLSGLHKYLSSEANV 95 
7_pfamImport   1 EGVESLVKRRLPQ-HVDSFEFVLepp-hgSVVVNDSYTVS-S-------TKNg-KVRIEGTTTSALLSGLHKYLSSEANA 69 
XP_008597633  25 DGVTAFIKRRLPD-HAASFQVSIdnaaatSATSGDRYTVS-S-------GSNg-KIQIQGTSPSAVLQGLHRYLADVAHV 94 
XP_006667416  25 DGVTAFIKRRLPD-HVDSFQVSIakapsaSIAANDSYNVS-S-------GGNg-KIHIQGTSPSAIMQGLHRYLADVAHV 94 
EPT01772      23 dGILSLVQRQVPD-HADAFTFTLv------QGEADSFMLSdT-------VNGs-GINVQCSSVSACARGLYTYLTQYGNV 87 
EMD32579      28 DGLYALVKRRLPD-HASSFTFRLt------ESDGDSFVISdA-------PAThrGITVECTTVSACARGLYTYLTDFGEV 93 
EGO02404      27 EGLYSLVQRRIPA-HAGAFTFKLss--gnSSNVTDTFTLS-DqisattqAGGa-KILVECSTISACARGLYTYVTEFGGV 101
6_pfamImport   1 EGLYSLVKRQIPA-HAGAFTFELsa--anTTNATDTFTLS-DigknatgNAT---ILIECSTISACARGLYTYVTEFGGV 73 
2VC9_A       239 SYNP-ImGSNLKm-pETMP 255 Clostridium perfringens
8_pfamImport  68 DIWWyA-GSQLEdapLVLP 85 
XP_013938974  96 DIWWyI-GSQLDqapRNLP 113
7_pfamImport  70 DIWWfI-GSQLDqtpKNLP 87 
XP_008597633  95 DIWWfV-GSELDkapKTLP 112
XP_006667416  95 DIWWfV-GSELDkapKALP 112
EPT01772      88 DIWW-T-GSRLDqiaSPLP 104
EMD32579      94 DIWW-T-GSRLGqlpRELP 110
EGO02404     102 DIWW-T-GSRLNelpSELP 118
6_pfamImport  74 DIWW-T-GSRLNelpSQLP 90 
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