Conserved Protein Domain Family
FTO_CTD

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pfam12934: FTO_CTD 
FTO C-terminal domain
This domain is found at the C-terminus of the FTO protein which was shown to be associated with increased BMI and obesity risk in humans. The N-terminal domain of this protein is a DNA demethylase and this domain is found to associate with the N-terminal domain in the crystal structure. This domain is alpha helical with three helices that form a bundle.
Statistics
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PSSM-Id: 432887
Aligned: 7 rows
Threshold Bit Score: 224.272
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002287957 366 GTWQYIRDKTKQVLDAStk-------fNSSEKTCQASKKTFEKFVahVRLQQLLMNEVEFEWLRQWYVQGSKHASLHP-Y 437
2_pfamImport   1 GTLDYIQRRCQEALKFL----------RSDLDSGTHTLRSLEPSV--LQHCEEIHNEVEFQWLRQYWFQGRRYEKFCS-W 67 
XP_012409272 326 GTLDYILKQCQLVMQNV----------WDDMEPKTMHLRSLEPSV--VKQGEEIHNEVEFEWLRQFWFHGHRYKKCTD-W 392
XP_001420808 251 DTFQYIKRRCIDALAIVpd--------------lERENKPLDAKQ--IQFLADVHREVEFQWIRMFHLQGEAHAAWHDtY 314
XP_003060875 338 DTFEHIKTRCERALRLLpgikkiaqvgPGPGDDLAAFARS-------AQMMGETHRECEFQWIRMFWLQGSRHAASHSaY 410
XP_004347827 456 gTRDYIVNLCNSAIADA-----------------LISGSHFDLMS--VTKVQQALTEVECGWIRQFWAHGLRHARIQA-F 515
XP_002502764 334 DTFDYVRGRCERALAVLpslkwragrwPKGTKPPRDASSTQLSDA--VRVLGETHREVEFQWIRMFWLQGTRHAAQHDgY 411 Micromonas commoda
XP_002287957 438 WHQPIEVLCDSYSNMEQRSVDLLVR-MKRASHDNKTEtfnt-elsEDLFDVFIETLTERSNQRSGWTARYRDPIFGEIPA 515
2_pfamImport  68 WRKPMEELEEAWRKMEIMTQLALAE-AEDAARTMERR--------REVAQVLLPFLTERQERRQLWRARCHSRLAQTLPP 138
XP_012409272 393 WHLPMSELEGLWKKMECVTNAVLCE-IRKEGLPMEQK--------NEIITDLLALLTTRQELRMEWCMRCQSRIAQNLPE 463
XP_001420808 315 WTRKIAELTEAWDRMEACFRVILSK-LKRSSRSPESP--------PRAYAMLLYALKTVKELRDEYTKRTKASAYASLPP 385
XP_003060875 411 WRQRIAELTQAWDAMELGYRWALDA-LRAGASTGAMP--------LRAYDVVSYLLEETRELRAEHARRSRAGAYEAMPA 481
XP_004347827 516 WKRVIESLELQWQQLESLTRQSLDSiTRHMSEALHTAtksenariATICDALLKAFEHRLRLREQWANFYSSPDFDHMEN 595
XP_002502764 412 WTRRIEELTQAWDVMELGLRFAMDAcARAADGKAKAE--------PRAFEMLRYLLETIAELREEHDARTQSGAYAQVPD 483 Micromonas commoda
XP_002287957 516 DERPFPCPLLDRtgdmtldeslkKGQMPEDLENVIAKLRE 555
2_pfamImport 139 DEAPMCRPDWHDdd--------sSMPLPFDLKAIIDALER 170
XP_012409272 464 EQRPICWPYWEDdd--------pEMPLPFNLSNIILELQG 495
XP_001420808 386 SQRPVDLPAYDN-----------TSPLPFELKPVIYFLEE 414
XP_003060875 482 DCRPVDEPKFDE-----------KSPLPFDLGPVLATLAG 510
XP_004347827 596 DLLPVRRPHFSA-----------SSPLPEALEPKIAQLVk 624
XP_002502764 484 DCKPVDLPGFDD-----------SSPLPRNLRPVLNTLER 512 Micromonas commoda
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