6AEJ


Conserved Protein Domain Family
FTO_NTD

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pfam12933: FTO_NTD (This model is not part of the current CDD release)
FTO catalytic domain
This domain is the catalytic AlkB-like domain from the FTO protein. This domain catalyzes a demethylase activity with a preference for 3-methylthymidine.
Statistics
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PSSM-Id: 520534
Aligned: 14 rows
Threshold Bit Score: 345.517
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6AEJ_A         26 DEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTLHKHGCLFRDLVRI---QGK-DLLTPVSRILIGNPGCTYKYLNT 101  human
3_pfamImport    1 RGYQQLWDSSYSGLALRRSPSLPAGLHARVQAALFTLRRKGCLLRDLVRI---RER-DVFTAVSRALLGEPGHTYRYLDT 76  
XP_002287957   87 KAFDSCLKTSYTGFRYDSPSALPSTLHGEFESSFDGMDAGDLFLYDTVQP---GKKrLTRTSVTRTLVGDPGSTYKYLGL 163 
XP_001420808   14 EPFARVHRAHYRGFVVDAPSVLPASLHDDVERAFDDMRSRGEFTHDVVSA---GNK-VSTTYVRRCLLGEDGMTYHYQKL 89  
XP_003060875   87 AEYERCMKTSYLGFHVDDPSALPEKTHREIARAFERMASDGIFHRDVLAA---GKS-VSPTFVSRTLLGERGMTYHYQRL 162 
Q5R7X0         36 DEFYQQWQLKYPKLILREASSVSEELHKEVQEAFLTMHKHGCLFRDLVRI---QGK-DLLTPVSRILIGNPGCTYKYLNT 111  Sumatran oran...
CBJ31658       72 PQFQEIVSKCFAGFHVEAAEAFDAKVHEEARQAFDGLEEGGVFRADVTQPfglGTK-CAVTYVTRTLAGDPGTTYKYLGL 150 
XP_064414865   44 AEFQHLWKTHYSKLLFKEANKTPHDLHEQVQSALLALLDHGCFFQDLVRM---KGK-DIFTPISRLLIGIPGCTYKYLNT 119  coelacanth
XP_007474929   56 TEFHQLWQENYSKLILREASSIPELLHKEVQQAFLILRKHGCLFQDLVRI---KGK-NLLTPVSRLLIGNPGYTYKYLNS 131  gray short-ta...
XP_011607995   47 RGFQQLWDSSYSGLVLKRSCSLPAELHARVQAALLTLRKKGCLLRDLVRV---RDR-DVFTNVSRALLGDQGHTYRYLDT 122  torafugu
6AEJ_A        102 RLFTVPWPVKGSNik----------------htEAEIAAACETFLKLNDYLQIETIQALEELAas--------------- 150  human
3_pfamImport   77 RLFAIPWHREDGEvkgr-------------rccDPEFRAACQALCELNGFFCSDVPLLNLSDHhl--------------- 128 
XP_002287957  164 RLFSHPWTDVDKDgnmqskeqkrvgstlhklgySEKTTSALLAMGRANAYLTERSNTMLKKYVapnvq------------ 231 
XP_001420808   90 RLFAQPWR----------------------------GREAYEVVRRLNETLTRSARERCEKLGgaf-------------- 127 
XP_003060875  163 RIFAHPWDEET----------------------QPDASHPFRAVKRLNDALVSRSTAVLRASSdprlg------------ 208 
Q5R7X0        112 RLFTVPWPVKGSNik----------------htEAEIAAACETFLKLNDYLQIETIQALEELaa---------------- 159  Sumatran oran...
CBJ31658      151 RMFSHPWTTTAKEadsd-------------gghGSGVPSALRRVGLLNNKLKERSLRLLRARGgr--------------- 202 
XP_064414865  120 RLFAIPWPTSGKVvr----------------ysDDQIFKACQALLKLNDYLCTETVKALQEQSla--------------- 168  coelacanth
XP_007474929  132 RLFTVPWPMEGSNik----------------ysKDEIFAACRAFFKLNDYLRKDTIQALDKLHli--------------- 180  gray short-ta...
XP_011607995  123 RLFAIPWHNEDSEvkgq-------------nccDPDLRAACKALWELNNFFCSDVAQLKEGDRlaqcakgetetkqaeqg 189  torafugu
6AEJ_A        151 -------ngQDE--------VDIK--------------------------SRAAYNVTLLNFMDP-QKMPY--LKEEPYF 186  human
3_pfamImport  129 -------edREEqag---gqGCSQpspr------------------qvrtGPVEFNVTLLNYMDP-AAMSQ--LKEEPYY 177 
XP_002287957  232 ---------------------------------------------ppglvGSAEYNLTLVNKMAS-TTMKRd-LKNEMAY 264 
XP_001420808  128 ------------------------------------------------aeSECEYNVTLINYMET-EGESEieLRNEEKF 158 
XP_003060875  209 ----------------------------------------------dgvdGSCDFNVTLINLMEPaSRCAEvpLKDEALF 242 
Q5R7X0        160 --------kEKAned---tvPLCMsadfprvgmgs----syngqdevdikSRAAYNVTLLNFMDP-QKMPY--LKEEPYF 221  Sumatran oran...
CBJ31658      203 -------kgKARreg---geGNEF--------------------------GSCEFNVALINRMEPsDDRPD--LKLEPTF 244 
XP_064414865  169 --------qAKEvevtekaaTLSMlqdsvgftkgrspvvgdqtncsfeleNRASFNVTLLNYMDP-LKMVH--LKDEPYF 237  coelacanth
XP_007474929  181 --------kSKDsed---saVFGMvpelsknil--------nvghdmelkKRTTYNLTLLNYMDP-QEMSY--LKEEPYF 238  gray short-ta...
XP_011607995  190 dteskhsedSKIseg---gdSESQ----------------------------Kseegdteskhseewdveskqseegcsg 238  torafugu
6AEJ_A        187 GMGKM---AVSWHHDENLVDRSAVAVYSYSCEGPe--eESEDDSHLeGRDPDIWHVGFKISWDI---------------- 245  human
3_pfamImport  178 GMGKM---AVGWHHDENLISHSPVAVYSHSCHND----KGESGEGG-SGEKACWRIGLKVAWDI---------------- 233 
XP_002287957  265 NMGKI---SVGWHRDSGLKDFSSIAVYQTLKD---------------TATANSWGVAIRA---Mdggtg----------- 312 
XP_001420808  159 DLGTT---SVSWHSDSSLRENSTVAVYHTYE----------------APERKDWRVALRA---Ln--------------- 201 
XP_003060875  243 GMGKArstSVSWHSDSSLQDVSTVAVYHQTD----------------DDDDDSWAVALKT---Ld--------------- 288 
Q5R7X0        222 GMGKM---AVSWHHDENLVDRSAVAVYSYSCEGPe--eESEDDSHLeGRDPDIWHVGFKISWDI---------------- 280  Sumatran oran...
CBJ31658      245 GQDRC---SVSWHADSCLEHYSSIAVYHVTDPEAknknADADGGDGsPAVPADWRIALRVEPDAegpsagklklaatedk 321 
XP_064414865  238 GMGKM---AVSWHHDENLVERSTVAVYSYSCKDShlasDDMKDDRNeGRDPVLWHVGLKRAWDI---------------- 298  coelacanth
XP_007474929  239 GMGKM---AVSWHHDENLVERSTVAVYSYNCEGPe--vLDDDELSPeGRNPAVWHVGLKIAWDI---------------- 297  gray short-ta...
XP_011607995  239 tkvegdwetgsrhsseegesslvkpsetcvagesehsegklpgwqaktslktesvgpgtqgkaqqkhssedkeeqvsrqg 318  torafugu
6AEJ_A        246 -----ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQP-RFSSTHRVAE 290  human
3_pfamImport  234 -----RTPGLTLPLESGDCYYMRDDLNSTHQHCVLAGESA-RFSSTHRVAE 278 
XP_002287957  313 -gplaSVPALLVPLPSGSLYYMFDDFNHNHEHAVIAGSDGvRYSSTHRVAR 362 
XP_001420808  202 ----aECEVLCVPLEDKATYYMCGEFNATHHHAVLTGSSA-RYSSTHRVAV 247 
XP_003060875  289 ----gVTPAMRTPLRSREMYYMLRDFNAHHHHAVITGESR-RFSSTHRVAV 334 
Q5R7X0        281 -----ETPGLAIPLHQGDCYFMLDDLNATHQHCVLAGSQP-RFSSTHRVAE 325  Sumatran orangutan
CBJ31658      322 ssrvdRAPAVAVALPSRSAYFLLDDFNHHHQHAVLAGQSH-RWSSTHRVAK 371 
XP_064414865  299 -----QTPGLAVPLLPGDCYFMLDDLNMTHQHCVLAGLQP-RFSSTHRVAE 343  coelacanth
XP_007474929  298 -----KTPGLAVPLHQGDCYLMLDNLNSTHQHCVLAGLQP-RFSSTHRVAE 342  gray short-tailed opossum
XP_011607995  319 cshpsppqvctdharfnvtllnymdpssmsqlkeepyygmgkmavgwhhde 369  torafugu
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