3MZK


Conserved Protein Domain Family
TPR_Sec16

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pfam12931: TPR_Sec16 (This model is not part of the current CDD release)
Sec16 Sec23-binding domain
COPII coat assembly protein sec16 (Sec16) is a multi-domain vesicle coat protein that binds to COPII-coated vesicles, regulating the transport of secretory proteins from the endoplasmic reticulum. This entry represents the C-terminal domain of Sec16 from eukaryotes and related sequences such as Protein transport protein Sec16A-B and Sec31A-B. This domain adopts a TPR-like fold and has been shown to act as a protein-protein interaction platform that binds Sec23. This interaction is regulated by alternative splicing upon T-cell activation to control protein secretion. Sec16 has also been shown to respond to nutrient signalling, coupling environmental stimuli to secretory capacity.
Statistics
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PSSM-Id: 520533
Aligned: 92 rows
Threshold Bit Score: 242.121
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3MZK_B        157 VLAFLQTGNHDEALRLALSKRDYAIALLVGSLMGKDRWSEVIQKYLYEGFtaG---PNdqkelaHFLLLIFQVFVGNSKM 233  brewer's yeast
XP_003647726 1010 ILASLQTGSPDAALDLALSQKDFALALVLSSLLGRETWASVVDRYLHEEFndStfrNPfs---vHLLAFVFQVFAGNSKR 1086
Q74ZJ8       1175 ILAHLQVGSPGAALDLALAQKDYALALVLSSLIGKDKWSEVVDTYLREEFsvSagnNQfs---vYLLALIFQVFVGNSNR 1251 Eremothecium ...
XP_013935918 1053 LSKYLEVGDKLSALQMAIGEEDWAIALIVANLLGPEAFAKVTKLYTERTFd----aADvl---qQNLSFCLQSSGENGLS 1125
EEQ40213     1405 IASMLQVGDRENAMNFSISRQDWALSLVIAHSISPEKFAQVASHYSKAMFplHkntHNkt---yHLMSIMLRCFAGNTKS 1481
A3LZ57       1101 VFGLIQGGHIDKALEFTLSKGDWALALVVSNFAGHDRFAKVAADYARFSFpyQk-sNNki---hHIIPILLKLAVGNVKS 1176 Scheffersomyc...
XP_036664443  966 VFALIQAGHIDKALEYTITKGDWSMALVLANFNGVESFARIASEYARNAFpfSk-aNNkv---lHIMPVLLKVLAGNVQS 1041
9_pfamImport    1 VFTLIQSGNLDKAIEYCISRSDWALALVISG--GSDKFHKVAAEYARNTFpfAk-sNNkv---lHIMPIILKVLAGNVTS 74  
4_pfamImport    1 IWRLLQVGETEKAIEFCTMKGDWTLALIIASMLGKDSFSKIATGYVSQTFpfQk-sPGkv---qHLMPLILKIFAGNIEG 76  
Q6BXI1       1073 IWSLLQIGNTEKALEFCLSKGDWALGLMIARFEGPEKFGKVASDYARTTFpfQk-sQSkv---hHLMPIMLKLFAGNFKS 1148 Debaryomyces ...
3MZK_B        234 AIKSFYtnnetsqwaSENWKSIVAAVLINipennedpllI--------PPVV-LEFLIEFGIFLTKKGLTAAASTLFIIG 304  brewer's yeast
XP_003647726 1087 ILQELTtdpvkgnwsLQYWNMILAAILNN----------InnsseaipIPPVvIEFLVGFGVYLIQHNQIEAGIICFVIA 1156
Q74ZJ8       1252 VLQELTanplkrdwaIQDWNIILAAVLNN----------IpkdvdprqLPPVvMEFLVGFGVFLVQSGKLAAGAVCFVIA 1321 Eremothecium ...
XP_013935918 1126 A----EqfhgkeewvIDNFRSVIPFVLLN----------Nk-------NPA---PVLVQVGTLLSEAGFELHGKLCFLLS 1181
EEQ40213     1482 LVESFSvdpnetefaKQSYREIIAAALVN----------Gv-------TG----EFFIEYGGFLASAGITCGSEICYMLA 1540
A3LZ57       1177 VIDDLNavategeyaSHHWREIVSSVIIS----------Gv-------SKSQ--DFLVEFGKFLGLHHNIAASEICYVIA 1237 Scheffersomyc...
XP_036664443 1042 VIEDLTsvvnegdyaDLHWRDIVSSVAMI----------Nt-------VKSK--EFLIEFGKLLITRGNQLGGEVSFILA 1102
9_pfamImport   75 IIDDLKavpnegeyaNLHWREIISSVAIS----------Gs-------LKSR--EFLIEFGKFLHHHGNFIGSELAYIMG 135 
4_pfamImport   77 VVQDLYainserdwsIQHWNEIVSSVLIN----------Sp-------PRAG--DFFIEFGKFMQNSGDKLISPICFVLA 137 
Q6BXI1       1149 AIDDITnvqaegewfIQNWRELVSLVVIN----------Kp-------QHGH--EFLCEFSKLLALSGQIIASQICLILA 1209 Debaryomyces ...
3MZK_B        305 nvplsnePVMADSDVIFESIGnMNTFESILWDEIYEYIFS----YD----PKFKGFSSILPQKIYHASLLQEQGLNSLGT 376  brewer's yeast
XP_003647726 1157 nvplsqnEVIPQSGVNFASLGsINSLDAILLSEVYEFSYVte-------nEQLTHFPTLLYSKAVHAATLLDYGFATTIS 1229
Q74ZJ8       1322 nvplsqnELLPHSGVKFECLGsINSLDAVLLSEVYEYYYTti-------nDNCPFFASLLLMKTVHASALLDYGLPTTVP 1394 Eremothecium ...
XP_013935918 1182 glpl-------ipkI---QTVsPSDIDSMIIDELYEYVLSs---sSnippAFSNGFPHILSVKVRHASYLLDVGHFAEAK 1248
EEQ40213     1541 gvimsrvPLQNGNVF---LSA-GSFTQSLVYTEIYEYILQmspmTSnvipPTG--IPHLIEFKIHRAQVLADLGHFTTSK 1614
A3LZ57       1238 glplspqALQPSGIV---VSViGSLTGTSMYTEVYEYILKi---sTvfvqQGVGIIPHLLPLKLKHATVLADYGLFNESQ 1311 Scheffersomyc...
XP_036664443 1103 glpl-----------gqqGFMvISSGSNSMYTQLYEYVLAt--------nGKSSSLPHLLPIKLKHASTLADYGLINESQ 1163
9_pfamImport  136 glpy--------gsgRDFNFMvLTSGHHSMYTEVYEYALNl---------nKSMYFPHLLALKLKHASMLADYGLINESQ 198 
4_pfamImport  138 glplssfPAANGNVL---FTSiGSSAKGIIYTEIYEYLMQl---sNsnvpPNG--LQHLIALKLNHASLLADMGSFGEAQ 209 
Q6BXI1       1210 glplssiPSQANGIL---FSViGFGSHSFAYSETYEYAMQl---sTtnipPTG--FAHLLPLKLKHAQVLADYGLFTESQ 1281 Debaryomyces ...
3MZK_B        377 KYTDYLSSSvrKLPKKDILTIN-LTRELSEVASRLSEsN----TGW----LAKPKLSSVWGQLDKSFNKYIGGD 441  brewer's yeast
XP_003647726 1230 KYVDVITNSmrNLAKNTSLSIA-LSNRLELINVRLSGiT----TGW----LGKPKFSSVWGQLDKSFNKFIAGD 1294
Q74ZJ8       1395 KYLDVITGLlrNAPKNSAIAVS-LTHQLESINLRLSGvT----TAW----IGKPTLSSVWGQLDKSFNKFIGGD 1459 Eremothecium gossyp...
XP_013935918 1249 KYVDHTTGVikS---KATYVDPtVAFANDQLLERLSQtEie-vSGWfggkLGRSGLDKVWGHLDKSFNKFVAGE 1318
EEQ40213     1615 KYCDAINSTlkVLG-KSPLVSAqALAEFQTLVMRLSEtSss-eSGWlgskLSKVNLDKVWGQLD----KFIGGE 1682
A3LZ57       1312 KYIDSINNNmkTLGNRSPYLNAaFIHELQSLIVRLQElGss-eSSWfsgkMSKVNLDNIWGQID----KFIGGE 1380 Scheffersomyces sti...
XP_036664443 1164 KYIDYINSIlkALGNRSPFVSQqLVQEFQNLIMRLSDlGsteqGGWfgskMSKVNLDKVWGQID----KFIAGD 1233
9_pfamImport  199 RYIDYINTSvkSLGNKSPYVTPnLLHEFQNLIVRLTEvGsgdqSNWfsgkISKVNLDKIWGQID----KFIVG- 267 
4_pfamImport  210 KYVDSLGSSlkQNE-KSPFYNQsIAKEFQNLAIRVSNsGss-eQGWfsgkISKVNLDKMWGQLD----KFIGGD 277 
Q6BXI1       1282 KYCDAISSIikATG-RSSFFNPvAFQEFQNLLMRISQsGas-dSGWfg--skKLTLDKMWDQLD----KFIGGD 1347 Debaryomyces hansen...
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