Conserved Protein Domain Family
Mid1

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pfam12929: Mid1 (This model is not part of the current CDD release)
Stretch-activated Ca2+-permeable channel component
MID1 is a yeast Saccharomyces cerevisiae gene encoding a plasma membrane protein required for Ca2+ influx induced by the mating pheromone, alpha-factor. Mid1 protein plays a crucial role in supplying Ca2+ during the mating process. Mid1 is composed of 548-amino-acid residues with four hydrophobic regions named H1, H2, H3 and H4, and two cysteine-rich regions (C1 and C2) at the C-terminal. This family contains the H3, H4, C1 and C2 regions. suggesting that H1 is a signal sequence responsible for the alpha-factor-induced Mid1 delivery to the plasma membrane. The region from H1 to H3 is required for the localization of Mid1 in the plasma and ER membranes. Trafficking of Mid1-GFP to the plasma membrane is dependent on the N-glycosylation of Mid1 and the transporter protein Sec12. This findings suggests that the trafficking of Mid1-GFP to the plasma membrane requires a Sec12-dependent pathway from the ER to the Golgi, and that Mid1 is recruited via a Sec6- and Sec7-independent pathway from the Golgi to the plasma membrane.
Statistics
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PSSM-Id: 493014
Aligned: 79 rows
Threshold Bit Score: 261.791
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007923271 162 TIYISANTCTQPvw---nGSEPQTEAPPQLTLYVSTSSGN-TDLGPNA-GNESQS-----VYPFVNGFVNAS-VDnASG- 229
XP_001830774  51 SLVLSVAVCSE---------------NSNLRFIVSNSSST-SNPNSDGgA----------LVNLVNGVGTYVsGY-PNG- 102
XP_003668005 100 LMFLSGNLCSTP----------NNTDGIELRVHYSFDENlmTN------TSNGQY------EAFKDGFMEALaIS-PIQt 156
XP_003673929 100 FIFLSGNICSRP----------ENSSDIELGVFYSFDKNilSN------SSLGTY------TAFGNGYMEQLaIS-PIQe 156
P41821        99 LMFISGNICQMP----------MNRSDVDLTIYYSFNETvlEN------PNIGQS------AVFQDGYIQALaIS-PVQs 155 Saccharomyces c...
Q6FJU2       142 LIFLSGNICQQP----------TNSTDLQIRVYYSFDEKmlSN------ISLGNF------ETFSNGYLEALqIS-PVNh 198 [Candida] glabrata
XP_001644330  84 LVFMSGNICSMD--------NITTDGSPSLRIYYGFNESilSD------LTTASY------GDYTEGYFSSYaIS-PFAn 142
XP_003688713  75 L-FISGNLLNIP-----------NTNGSVLRLYYSFSDTifAN------LSDTVY------EDFYDGYVSAM-VS-TFSd 128
XP_004179180  68 LLFISGTIESMPlryynlTDNTQFQNDTALQVTYYFSPS----------DPSNSTkigynNITFENGYIMALgTS-PITy 136
XP_002551528  82 LVFISGNLHSES-------ARLSNSTELQLAVWYSFDQEvtSD------TSKGSR------ALFSAGYMEALaAT-PLEd 141
XP_007923271 230 ------------------------DWYMAVSGPSLPDG---------------FSG--SWTYRLAVSIDD-YFYAAeMGD 267
XP_001830774 103 ----------------------------GVLQIEGSGS-----------------------FEVALSDTGqPIHAH--FP 129
XP_003668005 157 sasnt--------------tskyqNLYVVVQLFNSTTNepltd------efldPSQkdVWDYRLSISEND-LVFQW-DVR 214
XP_003673929 157 sqsnv--------------tseysNLYVVMQLVNATTNeali-------dytnGEDtrAWEYRLSISEND-LVYQW-DYR 213
P41821       156 sssna--------------tstysNLYVVAELVNSTTEqpl----------ssSDAseNWEYRLSISEND-LVFQW-DVR 209 Saccharomyces c...
Q6FJU2       199 tsngt--------------tlnskNLYVSVRLWDLINDkevdkd----dpnikNLTstEWDYRLSISEND-LVFQW-DTR 258 [Candida] glabrata
XP_001644330 143 dss-----------------ilysKLYIVAKLFDYDTQmple--------rtpENEnqFWNYTLSVSLNH-LTYQW-DSR 195
XP_003688713 129 tatdl--------------nttysTLYLALQVVDQETGvalv-------vngdSNSddTWDYQIAVSEKD-LYYQW-DRK 185
XP_004179180 137 nplfaleeqettnitgqslvleytTLHLEVSLINPQTGeiiqpsdnddyydyeDDDdnLWTYHLGVAEDD-QLFQY-DER 214
XP_002551528 142 qdgn---------------lteysNLYLVIEAYNVTSNsplq--------ltsTTQdlSWNYTIGVSQYD-LVFQW-DVR 196
XP_007923271 268 PFLFQVDTDSDSALLVTDNLTQADaSDPLYT--------EWMDL-GAP-----FIMFAVNNNLSG-MMG-LESSFCGLQT 331
XP_001830774 130 PLPLLGDTTSNQAILFSPPFFVPEpIQPRYPnyt---mlPVDIPqDSPpqtpdYTLSLFPTREDD-----YPRSSCFLSA 201
XP_003668005 215 SWLDVLDTDHNSALLTTGNVTa---DAQVFYnyst-ydtSL------------YDLYVYSYEDSLkFEDgLSLSLCAIKN 278
XP_003673929 214 SWLQVLDTDHSSALLITGNVSt---DAKVYHnysi-ydpSL------------YDLYIYSYEDSLkFDQdLNISLCAVKN 277
P41821       210 PWVEVLDTDMNSALLSTGNVTa---DAKVYHnysi-ydpSL------------YDLYVYSYEDSVqLNQnYNLSLCAVKN 273 Saccharomyces c...
Q6FJU2       259 SWIDVLDTDSTSALISTGNVTd---DGQIYSnyti-ydpTL------------YDLYLYTYDEYQkFLNvSELSLCAIKN 322 [Candida] glabrata
XP_001644330 196 SWLQVLDTDYNSALLSIGSSS--VaNSTKSTgvss--------------alkyYDVYIYDTKEADiIDEmFGMSVCAIKN 259
XP_003688713 186 TWIEVMDTDYNSVLLSIGQFV----TATSAKsnstssdeE-------------YVLYIYTPEEAEkITAnRNCSISAVKN 248
XP_004179180 215 SWIHVLDTDHNSALVTSGNDS--TrLTTYLKtnnt--------------lespYELFLYSLKDSEiIENnLNCSLSAILN 278
XP_002551528 197 SWVELVDSDADSALLVTGNVT----SLTTTSansslydvGL------------YELYLYSYDELIaFDKaLPHSLRAVQD 260
XP_007923271 332 FAsdnhQIQAKQDdmggntTNVQM--------------------------GMITR-GlgHKPKEQFLVNALNSSSSYHAF 384
XP_001830774 202 ES----QLESGTI------TSEETp-------------------------WLRDEdG----WRLQYLIRGLEPSTNYTAY 242
XP_003668005 279 GP----YLVSSVD---------SGrvssslee-----------eglviqkSIREGgG--NGVSEYFYITGLNSSTTYAAI 332
XP_003673929 278 GP----YLVTSEG---------SNnlskslev-----------tdlkiqkSIEDSa---AGVSEYFYITGLNSSTTYAAY 330
P41821       274 GP----YLVSSQNts---nATVTSnstnpler-----------tdlaiqkKITEYgG--S-VTEMFYVTGLNASTTYVAY 332 Saccharomyces c...
Q6FJU2       323 GP----HLVSSEG------ASATNpplemlqe-----------tglkiqkRIAESs---SGIAEQFYITGLTPNTTYAAF 378 [Candida] glabrata
XP_001644330 260 GP----YILSSRD------FATLNinttmlnn----------dtlaaqkiSLGTFyG--S-STGQFYITGLNSSTTYSAY 316
XP_003688713 249 GP----HIISSEN------VTESDvdlslldr----------edfqifklNVDAYtS--N-NHGQYYITGLNSSTSYVGF 305
XP_004179180 279 GP----YMATSIS------NDSNStpstnykkislnvhslqiqkqlvgddQL-------SNVQDMLYISGLAPNTTYALY 341
XP_002551528 261 GP----YLASSVN--------NSAvkielsns-----------stpeivkSLTVRgG--S-VKEQFYITGLNHSTTYGVY 314
XP_007923271 385 LAMDG---NSTATGdgvvgGGGKVWAPVPFSTK-SDGNCQLLFNLTFCDEVAYAVPANPS-Nee-vsSFEALQNFYEDYT 458
XP_001830774 243 VL-----------------DDTRVFGPIYFTTKsAAFPCHLVSNLPYCPRVAYAMPLAPPpDgadtyTGDTLPQELQDPL 305
XP_003668005 333 LTKKIgksGNLSD------VGGVLFAKQYFTTR-DTNTCSLIYDLHFCDGVAYSVPTSSFaYd----NKTLIAETYDNIA 401
XP_003673929 331 LTKKIgksGNITD------VGGVLFSKEYFSTK-DTDTCSLIYGLDFCTGVAYSVPTSSLaFg----NKTLLAETYDHIA 399
P41821       333 LTKKIsngDGLSS------VGGILFSHVYFTTR-STDVCSLIFGLDFCSDVAYSVPTSSFsVg----NKTLMAQTYDHIA 401 Saccharomyces c...
Q6FJU2       379 LTKKIgkgQSLSN------VGGVLFDAEIFTTQ-TSDACSLIFGMSFCSDNAYSVPSSEFtNg----NKSDLAIEYDNIA 447 [Candida] glabrata
XP_001644330 317 LVKKIvdtNAILD------IGGVLFRRIDFTTK-PDNTCSLIFGLNFCSGVAYSVPTSSKfPs----DKDAIAKMYDSIA 385
XP_003688713 306 LTQTItgsNG-SSDen--sSGGLLYGNFTFSTK-PDNTCSLVFGLNFCSGVAYSVPTPSElQg----NKSAIVQIYDSIA 377
XP_004179180 342 LIRKIgtrMSNNDNs----ITGVVFSRQLITTK-VKSTCSIIFNLDICSSVAYAAPTPLKyYv----NKTAMANDYDSLV 412
XP_002551528 315 LTKKIsdnTEVLSD-----SGGILFSKATFTTM-ADDSCSLIFGLDFCDGVAYSVPTAKSaGt----NKTVTSLIYDGIA 384
XP_007923271 459 TRWYAPFNRTLAQVACNTTSDAQYSLARNCTECAAAYKEWLCAVSIPRCEDFSNQ---APYLQPRNVG--------Qkfy 527
XP_001830774 306 KSYLTNFTISLGRFACGRD---LYSPLVDCIDCQREYRKWLCAISLPRCSEPSPSnpnAFTALAPDPTatglsatkNeqq 382
XP_003668005 402 EALFANFSKALQLIPCDAESDARYSPLRTCDDCSKSYGDWVCAVSIPRCTTTSST-----YYMSRNKT------------ 464
XP_003673929 400 SAIYGNFSKALQLISCDAESDARYSPIRTCDDCATSYRNWVCAVSIPRCSTSSSE-----YFVHRDHL------------ 462
P41821       402 EALYANFSKALQLISCDADKDARYSPVMTCDDCAEAYRDWVCAVSIPRCTTTSSQ-----YYIHRDKS------------ 464 Saccharomyces c...
Q6FJU2       448 SALYSNFSKALQLVPCDADLDARYSPIRTCDDCATSYRDWICAVSIPRCSTTESS-----SYIYRSKT------------ 510 [Candida] glabrata
XP_001644330 386 ESLYANFSNALQIIPCDTELDARYSPFRTCDDCAASYMNWLCAVSIPRCTTDESP-----LFIRRQKS------------ 448
XP_003688713 378 ESLYTNFTKALQIIPCDTELDARYSPLRTCDDCAASYLDWLCAVSIPRCTTTETP-----HFIYRNKN------------ 440
XP_004179180 413 RSLYENFTTALQLIPCDAELDQRYSPLRTCEDCAQSYLNWLCSIMIPRCSSPGNF-----GSIFRKKF------------ 475
XP_002551528 385 SSLYSNFSKALQMIPCDTEKDARFSPLRTCNDCANSYRNWLCAVTIPRCTTENSS-----YYIHRDKT------------ 447
XP_007923271 528 nndsmldsdfllsnyvpmtkaptlegsiayqqtynwsfATNRSRNQMIDEVIRP-GPYKEVLPCEDLCYSLMQSCPASIQ 606
XP_001830774 383 qvls----------------------------alvplqTSTPPRNSNLPPFDSP---YQMLLPCLETCTAVDRACPPFLG 431
XP_003668005 465 -----------------------------------------KNRNKYIDIYVQPvSDYYEILPCIDMCHAIVRDCPSDFG 503
XP_003673929 463 -----------------------------------------DNRNSYINTFIKPsRDYFEVLPCIDMCHAMVRDCPSDFG 501
P41821       465 -----------------------------------------HNRNDYLNKFIKPlDDYYEILPCIDMCYTLVRNCPSDFQ 503 Saccharomyces c...
Q6FJU2       511 -----------------------------------------DNRNSYVNKFIKPtEDYYEVLPCIDMCYAIVRDCPSVFN 549 [Candida] glabrata
XP_001644330 449 -----------------------------------------QNRNSYINNDIAPiNDYYEVLPCIDMCYSMVRDCPSDFG 487
XP_003688713 441 -----------------------------------------VNRNSYINEDIKPiRDYYEVLPCIDMCHSIVRDCPADFG 479
XP_004179180 476 -----------------------------------------KSRNSLIDTFIQPtDNYYELMPCIDSCYEMVRDCPAQFG 514
XP_002551528 448 -----------------------------------------QNRNDFLNQQIQPiHDYYEILPCIDMCYNLAADCPPDFQ 486
XP_007923271 607 FACPYPGR---GLEVSYGKRSTSg----LTCSYLGAV 636
XP_001830774 432 FKCPTSQF---NGAASYGIGYIDgkegdEKEGLTGQA 465
XP_003668005 504 FACPNPQYtneLLYYSYNYYKKGat--lDTCNFIGNV 538
XP_003673929 502 FACPNPKRdddLLNYSYNYYRSGtn--lETCNFIGNV 536
P41821       504 FSCPNDLTtedLLYQSYNFYMDtd---ySTCNYIGNS 537 Saccharomyces cerevisiae S288C
Q6FJU2       550 FKCPDQESepeLLFQSYNIFKQSsp--fITCNFIGNA 584 [Candida] glabrata
XP_001644330 488 FACPSITSnydLLSLSYNFLLENfd--fPTCNYIGDY 522
XP_003688713 480 FACPEPSNsnnLLFSSYNYYYEDfd--yITCNFIGNY 514
XP_004179180 515 FSCPNIKSsdeLFRHSYSYFNSSes--sETCNFLGNS 549
XP_002551528 487 FSCPSKTShseLLYLSYSVWEENd---fHTCNYVGNS 520
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