8P50


Conserved Protein Domain Family
TcdA_TcdB_pore

?
pfam12920: TcdA_TcdB_pore (This model is not part of the current CDD release)
TcdA/TcdB pore forming domain
This family represents the most conserved region within the C. difficile Toxin A and Toxin B pore forming region.
Statistics
?
PSSM-Id: 520525
Aligned: 6 rows
Threshold Bit Score: 718.549
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
8P50_A       1636 GARFEAASTRLAQEHQLD-SRWLPIIATTEEQGEg--RYRVQFINRDQPE-QtRWLDTDDSTFVEFRRFVDEHMSVLNEH 1711 Photorhabdus ...
Q7MZW9       1615 GARFEVASARLAQEHQLD-SRWLPIIATTEDQGEg--RYRVQFINRDQPE-QtRWLITSDSTFVEFRRFIDEHMAVLNEH 1690 Photorhabdus ...
1_pfamImport    1 GEKFDKAITELAGEHKLD-QRWVPVIDNIKEKSEg--GYRVQFINRDNLEe--KWVNSNDGTFVKFRHFIDEHMRTLSQH 75  
2_pfamImport    1 AEDFQQATEQLYSKNALStEEWLPVLGSLRETESqpgSYSLQFINTARSKvPpRTFTTDDQRIINFIHSYDNDLKVVSKS 80  
Q189K5        864 LENVSDELYELKKLNNLD-EKYLISFEDISKNNS---TYSVRFINKSNGE-S-VYVETEKEIFSKYSEHITKEISTIKNS 937  Clostridioide...
Q189K3        862 IESISDALCDLKQQNELE-DSHFISFEDISETDE---GFSIRFINKETGE-S-IFVETEKTIFSEYANHITEEISKIKGT 935  Clostridioide...
8P50_A       1712 -FTLESGRMRPRGGVGEAAPVDGLNAGFAVQALIQWFSDKNRHdaan----gmasPDLATALKVHSYLNFVQMVHGGVQD 1786 Photorhabdus ...
Q7MZW9       1691 -FTLEHGRMRLRGGVGEAAPVDGLNAGFAVQTLIQWFADKNRHdaas----gvisPDLATALKVHSYLNLVQMAHGGVQD 1765 Photorhabdus ...
1_pfamImport   76 -FTLERGQMRHKGGVGEAAPIDGLNAGFAVQTLIQWFANKNRNdaah----gissPDLATALKIHSYLNYAQMTHSSIND 150 
2_pfamImport   81 -HKYTEGKFTLRTGILEAEAVHGLNSAFIIKTLIPWFADRNRTtvasdkasntttNTLETALRVHTYVNLTQMAHGALED 159 
Q189K5        938 iITDVNGNLLDNIQLDHTSQVNTLNAAFFIQSLIDYSSNKDVL------------NDLSTSVKVQLYAQLFSTGLNTIYD 1005 Clostridioide...
Q189K3        936 iFDTVNGKLVKKVNLDTTHEVNTLNAAFFIQSLIEYNSSKESL------------SNLSVAMKVQVYAQLFSTGLNTITD 1003 Clostridioide...
8P50_A       1787 VIKVTALVRTALRGEVVAAQTsfkefalslghtVNEG---VGVLFGGAMIGLDAYELAHA-------ENDVQKAVFGTQL 1856 Photorhabdus ...
Q7MZW9       1766 IAKVTALVRTALRGEVVAAETslkdfasnlghtVNEG---AGVLFGGAMVGLDAYELAHA-------ENDVQKAVFGTQL 1835 Photorhabdus ...
1_pfamImport  151 VMKVTELVHTALRGEVVGAETslkefssalahtANEG---IGLLFGGAFIGLDAYELTHA-------ETDTQKAVFGTQL 220 
2_pfamImport  160 SAKLVSLYRAMASESRGVTSSlfss-----lshVSTG---VGVGLNITSVVLDSLELAHA-------QNESQKAVYGTQL 224 
Q189K5       1006 SIQLVNLISNAVNDTINVLPT------------ITEGipiVSTILDGINLGAAIKELLDEhdpllkkELEAKVGVLAINM 1073 Clostridioide...
Q189K3       1004 AAKVVELVSTALDETIDLLPT------------LSEGlpiIATIIDGVSLGAAIKELSETsdpllrqEIEAKIGIMAVNL 1071 Clostridioide...
8P50_A       1857 AFDSASFVTGAAGIGAGLvgastagavlGGAGVILGGLAVGFTALAQAFGAVAEDAKAVGRYFDTVDKAYKGNGYRYDNE 1936 Photorhabdus ...
Q7MZW9       1836 AFDSASFVTGAAGVGAGLvgastagavlGGASVILGGLAVGFTALAQAFGAVAEDAKAVGRYFDTVDKAYKGNGYRYDNK 1915 Photorhabdus ...
1_pfamImport  221 AFDSASFVTGAAGVGAGMvgasttaavlGGAGVILGGLAVGFTALAQAFGAVAEDAKAVGHYFDMLDKAYEGNGYRYDSK 300 
2_pfamImport  225 AFDSAGLVTTGVGIGAGVfgapivagvaSSLAVPLAGLGIGFTALAEAFGRVADDAKAVGNYFADLDAAYQQGGYRRTEK 304 
Q189K5       1074 SLSIAATVASIVGIGAEV----------TIFLLPIAGISAGIPSLVNNELILHDKATSVVNYFNHLSESKKYGPLKTEDD 1143 Clostridioide...
Q189K3       1072 TTATTAIITSSLGIASGF----------SILLVPLAGISAGIPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDD 1141 Clostridioide...
8P50_A       1937 kQ-------VLVPLAGAVIKTLDLSKNQIDFDSQYIYRTHSG-S-TGSGKINYFFWvgdFPRMVHd--RGQAIEVRSGIG 2005 Photorhabdus ...
Q7MZW9       1916 nK-------VLVPLAGAVIKSLDLRKHQISFDSQYIYRTHSG-S-TGSGEINYFFWvgdFPRMVHd--RGQAIEVRSGIG 1984 Photorhabdus ...
1_pfamImport  301 qD-------VLVPLAGAVIKTLDLRNKQVGFDSQYIYRTHSG-S-TGSGEINYFFWigdFPRMVHd--RSQAIEVRSGIG 369 
2_pfamImport  305 vAangnpytVMEPIPGAVIRQLDLRHGNLTFDSQYLYRNDPTyS-VGSGHSNYFFW---WPGRSAntkKTQAINIREGIG 380 
Q189K5       1144 -K-------ILVPIDDLVISEIDFNNNSIKLGTCNILAMEGGsGhTVTGNIDHFFS---SPSISS---HIPSLSIYSAIG 1209 Clostridioide...
Q189K3       1142 -K-------IMMPQDDLVISEIDFNNNSIVLGKCEIWRMEGGsGhTVTDDIDHFFS---APSITY---REPHLSIYDVLE 1207 Clostridioide...
8P50_A       2006 YKDVSRPLeh--gDSNVVILPGTPKSYISYEYMLLPGATTRHDAG---FDVIRRLEEDKrFDYDFYIFPGEETIRRIHHE 2080 Photorhabdus ...
Q7MZW9       1985 YKDISRPLeh--sDSNVVILPGTPKSYISYEYMLLPGATTRHDAG---FDVIRRLEEDKrFDYDFYIFPGEETIRRIHHE 2059 Photorhabdus ...
1_pfamImport  370 HKKASRDLeh--sDSNVLILPGTPKSFINYEYMQLPGATTRHDAG---FDVIRRLEEDKrFDYDFYIFPGEVTIRRIHQE 444 
2_pfamImport  381 HKQAQIDLpfhprSSDILILPVTMKSYINYEYMSLPFVTARNDRG---FDVLRRLEEDGrFDFDFYAFPSERVVRRIKPE 457 
Q189K5       1210 IETENLDF-----SKKIMMLPNAPSRVFWWETGAVPGLRSLENDGtrlLDSIRDLYPGK-FYWRFYAFF-DYAITTLKPV 1282 Clostridioide...
Q189K3       1208 VQKEELDL-----SKDLMVLPNAPNRVFAWETGWTPGLRSLENDGtklLDRIRDNYEGE-FYWRYFAFIADALITTLKPR 1281 Clostridioide...
8P50_A       2081 YVDTPIEVVLDQRNRQLVAPEL-PKELHGFLCYEIKGAGGEYLIGLNE---GAKVNLTSDva--------sT-WIID--- 2144 Photorhabdus ...
Q7MZW9       2060 YVDTPIEVVLDQRNRQLVVPEL-PKELHSFLRYEIKGAGGEYLIGLNE---GTQVKLTSDsas------alSrWIID--- 2126 Photorhabdus ...
1_pfamImport  445 YVATPIEVMLDQSSRKLIVPDL-PKELHGYLHYEIKGAGGEYLIGLNE---GTSVKLMSDvpkpdgsgnipSrWIID--- 517 
2_pfamImport  458 FVETPVDIILDDQDRDIVIQQL-PEDVHGILSYRLTGGKGKYRISLQK---GVSLSLQGNnt--------aThWILD--- 522 
Q189K5       1283 YEDTNIKIKLDKDTRNFIMPTItTNEIRNKLSYSFDGAGGTYSLLLSSypiSTNINLSKD-----------DlWIFNidn 1351 Clostridioide...
Q189K3       1282 YEDTNIRINLDSNTRSFIVPIItTEYIREKLSYSFYGSGGTYALSLSQynmGINIELSES-----------DvWIIDvdn 1350 Clostridioide...
8P50_A       2145 -------------SSQLASD---SISVSKDQ-LLVGekgkEVVVKLYLAQNSQ-------VLVVNGKGEVRKVDFTSLTA 2200 Photorhabdus ...
Q7MZW9       2127 -------------SSQLASD---SISVSKNQ-LVVG----GVVVELDPTQNGQ-------VLVVNGKGEVREVDFAGLTT 2178 Photorhabdus ...
1_pfamImport  518 -------------SSQLDNG---TIKVLENR-LEIG----GVVVEIDPSRNGQ-------VLVVNSKNEVHEINFSAQTA 569 
2_pfamImport  523 -------------ASHIDSDfdaSLSKKDNRqLHIG----SIKITLPETSVN--------ISLINNAGVFSVGQNKEHQW 577 
Q189K5       1352 evreisiengtikKGKLIKDvlsKIDINKNK-LIIG----NQTIDFSGDIDNKdryifltCELDDKISLIIEINLVAKSY 1426 Clostridioide...
Q189K3       1351 vvrdvtiesdkikKGDLIEGilsTLSIEENK-IILN----SHEINFSGEVNGSngfvsltFSILEGINAIIEVDLLSKSY 1425 Clostridioide...
8P50_A       2201 QVISEDASKWQV-PGQQIEQHLS--DLAKAHQLHGQYVVVE------------------------------NYrh---qG 2244 Photorhabdus ...
Q7MZW9       2179 QVVSEDAGKWQV-PGQQIEQHLS--DLAKAHQLHGQYVVVE------------------------------NYsh---nG 2222 Photorhabdus ...
1_pfamImport  570 DVVREDASKWQV-SGQQIEQHLK--DLAKAHQLHGQYVVVE------------------------------NYkh---nG 613 
2_pfamImport  578 QITEIETNADQFnSLQALHDHLR--QLSNSDHHNRPYVVVE------------------------------HYrhsppqS 625 
Q189K5       1427 SLLLSGDKNYLIsNLSNIIEKINtlGLDS---KNIAYNYTDesnnkyfgai-----------sktsqksiiHYk----kD 1488 Clostridioide...
Q189K3       1426 KLLISGELKILMlNSNHIQQKIDyiGFNSELQKNIPYSFVDsegkengfingstkeglfvselpdvvliskVYm----dD 1501 Clostridioide...
8P50_A       2245 RDVGRAFYDVT-----------KDRMLFTD--TTNEQAkraqlgavmg-dyayfydadnAVAWRVD 2296 Photorhabdus luminescens
Q7MZW9       2223 RDVGRAFYDVG-----------KERMLFTN--TTHEQTrhaqlgavmg-dhayfydadnAAAWRVD 2274 Photorhabdus laumondii subs...
1_pfamImport  614 RDVGQAFYDVA-----------KERMIFTD--TTQEQAkhhaqlgavmgdhayfydannAVAWRVE 666 
2_pfamImport  626 RPVGRAFYETG-----------RDRMIYTNvpDAADFLnnvelakvk---gdkawfyrdTTLWQ-- 675 
Q189K5       1489 SKNILEFYNDStlefnskdfiaEDINVFMK--DDINTI---------------------TGKYYVD 1531 Clostridioides difficile 630
Q189K3       1502 SKPSFGYYSNNl----------KDVKVITK--DNVNIL---------------------TGYYLKD 1534 Clostridioides difficile 630
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap