3EZ1


Conserved Protein Domain Family
Asp_aminotransf

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pfam12897: Asp_aminotransf 
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Aspartate amino-transferase
These proteins catalyze the reversible transfer of an amino group from the amino acid substrate to an acceptor alpha-keto acid. They require pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze this reaction. Trans-amination reactions are of central importance in amino acid metabolism and in links to carbohydrate and fat metabolism. This class of amino-transferases acts as dimers in a head-to-tail configuration. It has been demonstrated that these proteins are aspartate amino-transferases from Bacteria (Jansen, R.S. et al. Nat Commun 11, 1960 (2020)).
Statistics
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PSSM-Id: 403948
Aligned: 4 rows
Threshold Bit Score: 732.436
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3EZ1_A          3 TKEASRPALDLARQAYEAFKARGLNLNXQRGQPADADFDLSNGLLTVLGAEDVRX-DGLDLRNYpGGVAGLPSARALFAG 81  Deinococcus ge...
Q9RU17         29 TSSATPDALAQAQAAYAELKARGLKLNLQRGQPADADFDLSNPMLSVLGENDTRY-DGTDLRNYpGGVAGLPSARALFGN 107 Deinococcus ra...
jgi:Tpau_4021   8 SQSELADVHATLTGLYETLKAQGLTLDLTRGKPAPDQLDLSNALLALPGEGDYRAaDGTDTRNY-GGLAGLPELRAIFGE 86 
CAN96406        8 SPDALASLTRELEARFAAFEARGLKLDMTRGKPSSEQLDLANGMLALPGAGDLVAsDGSDTRNY-GGLDGLPEMKAIFAE 86 
3EZ1_A         82 YLDVKAENVLVWNNSSLELQGLVLTFALLHGVRGSTGPWLSQ-TPKXIVTVPGYDRHFLLLQTLGFELLTVDXQSDGPDV 160 Deinococcus ge...
Q9RU17        108 YLDLKPENVLVWNNSSLELQGLVLGFALLHGLRGSQGGWVHE-KPKMIVTVPGYDRHFLLLETLGFKLLAVDMQDDGPDV 186 Deinococcus ra...
jgi:Tpau_4021  87 LLGIPTANLYAQNNSSLEIMHRLITLAWIHGTVDGERPWGAEeTVKFLCPAPGYDRHFAITEELGIEMIVVPLNPDGPDM 166
CAN96406       87 MLEVPSEQVIVGGNSSLTMMHDAVVRALLHGVPDGSGPWVKQpKVKFLCPSPGYDRHFAICEHHGIEMITVDLRDDGPDM 166
3EZ1_A        161 DAVERLAGTDPSVKGILFVPTYSNPGGETISLEKARRLAGLQAAAPDFTIFADDAYRVHHL-VEEDRAEpvNFVVLARDA 239 Deinococcus ge...
Q9RU17        187 DAIERLAANDASVKGILFVPTYSNPGGETISAEKARRLVGLKAAAPDFTIFADDAYRAHHLfGEGERDVpvNFVALCRDA 266 Deinococcus ra...
jgi:Tpau_4021 167 AVVKELVAKDPSIKGIWAVPKFSNPTGSVFSEEVTRELASMPTAAPDFRIFWDNAYAVHALvGDAPSDP--DILGLAAEA 244
CAN96406      167 DQVEKLVAEDAAIKGMWSVPKYSNPTGTTYSPEVVRRLAAMKTAAPDFRLFWDNAYAVHDLyAEGDKLA--NIVPACQSA 244
3EZ1_A        240 GYPDRAFVFASTSKITFAGAGLGFVASSEDNIRWLSKYLGAQSIGPNKVEQARHVKFLTEYPgGLEGLXRDHAAIIAPKF 319 Deinococcus ge...
Q9RU17        267 GHPDRAFVFASTSKITFAGAGLGFVGSSEDNIGWLGKYLGAQSIGPNKFEQARHVKFLEGYDgGLEGLMRDHAALIAPKF 346 Deinococcus ra...
jgi:Tpau_4021 245 GHPNRPYVLASTSKITFAGAGVSFFGASAENLAWYGKYTGLTSIGPDKVNQLRHVRFFGDAE-GVRAHMRRHRDLIAPKF 323
CAN96406      245 GHPNRPIVFASTSKISFAGSGVAAMASSPANVADAKKHLGIQTIGPDKVNQLRHVRFYKDYK-GLLSHMQRHAELMRPKF 323
3EZ1_A        320 RAVDEVLRAELGe-GGEYATWTLPKGGYFISLDTAEPVADRVVKLAEAAGVSLTPAGATYPAGQDPHNRNLRLAPTRPPV 398 Deinococcus ge...
Q9RU17        347 QAVYDALSAGLGegGGGYATWRTPRGGYFISLDTVDPVAERVVQLADEAGISLTPAGATYPGGNDPKNANIRLAPTRPPL 426 Deinococcus ra...
jgi:Tpau_4021 324 ARVLEILEDRLA--AAKVASWSEPTGGYFISLDVLDGTAKRTVALAKEAGIALTAAGATFPHGEDPHDRNIRLAPTFPSI 401
CAN96406      324 EAVTTTFERELG--GKGIATWTSPRGGYFVSLDTLDGCAKEVVRLANKAGVKLTGAGATYPYGRDPRDRNIRVAPSMPPL 401
3EZ1_A        399 EEVRTAXQVVAACIRLATEEYRAG-H 423 Deinococcus geothermalis DSM 11300
Q9RU17        427 AEVEEAMRGVATCVKLAAEEYRAGqH 452 Deinococcus radiodurans
jgi:Tpau_4021 402 AELETAMDGVATCVLLASAEKLMQqQ 427
CAN96406      402 EQIRVAMDVVAVCVQLASVRKLAG-- 425
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