Conserved Protein Domain Family
FctA

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pfam12892: FctA 
Spy0128-like isopeptide containing domain
The FCT and equivalent region genes of Streptococcus pyogenes and other related bacteria encode surface proteins that include fibronectin- and collagen-binding proteins and the serological markers known as T antigens. Some of these proteins give rise to pilus-like appendages. The FctA family is found in many Firmicutes and related bacteria. In S. pyogenes, the pili have a role in bacterial adherence and colonisation of human tissues. Members of this family have a conserved N-terminal lysine and C-terminal asparagine that can form a covalent isopeptide bond.
Statistics
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PSSM-Id: 492983
Aligned: 96 rows
Threshold Bit Score: 32.7661
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCX73726       424 VHGKKVL---EGrdlradDTFHFR-IKAENDAPLPGE----------------------------------TVVtndv-- 463 
57_pfamImport    1 LQITKAL---NGrdm-ekDQFTFT-VTPKATEGSTTAeeaaekfglanaantykneaaeagavttinvldgKNV------ 69  
44_pfamImport    1 IRGTKTL---TGdtl-akDQFSFA-LTKAEKVGSEGAtvplpvidenslev--------------------------gnt 49  
47_pfamImport    1 FSATKQLdgtta--yasgNTYTFKnFAVEEVSADAANatkvkdittg--------------------------------- 45  
WP_012876932  1470 PWFSKLL---KGrnwlpdeeFTFV-IDGvvkdgveppmpaa-------------------------------------tt 1508 Xylanimonas ...
58_pfamImport    1 LKVTKEL---TGrkwldtdTFSYT-LTA-ADEATVEAiengfitlpenag----------------------------gl 47  
CDC54989        38 AGVTKNLhiaEGitv-pdTTFTFN-ITQTAGDATTVTktttaafkadtv------------------------------- 84  
WP_012797229    46 AAVTKVLhsneg--stvtATFSFT-ATGTTVAIDDEGtvseptdglgvtiasve---------------------lttag 101  Slackia heli...
61_pfamImport    1 AQITKELklaegi-tipraTFHFT-ADKitedapkae--------------------------iesvsysaEDLkgdlse 52  
60_pfamImport    1 VQGRKTL---VGrdslvdEEFSFT-LSA-ANTAARTGlkenfiifngdtaqdt----------------------mqktv 53  
CCX73726       464 -------dgkfHFqm-------syVKAGI-YKYTIQEvedte----hpipgI-RYD-KVKY--EVTVKVT---------- 510 
57_pfamImport   70 -----------TFt---------qADAGKtFTYEAAEtag--------tntAyTYD-TDVR--TVTVKVK---------- 108 
44_pfamImport   50 vknteatanniFFgtit----ydvQDAGt-YKYYFQEvvped-----eepgM-VYDdEEKV---VTVTVTydegvlnstv 115 
47_pfamImport   46 -ttagnttgaiTFadkvsyssataGDEGk-HYYKVYEtssg-------ytdV-TTD-TNYYilTVDVALDnatnptklva 114 
WP_012876932  1509 akvtsanavrfDFgsi------vfDKAGt-YTYVVSEqvpsd-----kapgL-DYD-GRSA--TVTIVVK---------- 1562 Xylanimonas ...
58_pfamImport   48 eitkasaghqaAFgdi------qfTIAGT-FKFNVTEqpsg-------iagI-TDD--QEAerTVVVKVT---------- 100 
CDC54989        85 tndlvskaattELada-----tkyPHAGv-YTFTVNEvkgd-------vagM-TYD-TKTY--TVNVYVV---------- 137 
WP_012797229   102 dgedvsgtgkiTFpa--------yTHAGv-YAYMIEEaqqativnddgsegTmTYS-TDKYlmRVYVENE---------- 161  Slackia heli...
61_pfamImport   53 gvykinkagtiTFge--------fPHAGE-YQYHVQEtadtyh--tasgegM-TYS-TEAY--TMHVYVI---------- 107 
60_pfamImport   54 ngltnnqaatfDFdsi------efKRPGT-YVFSVVEnape------ngngM-VYD-RHTA--RVRVIVT---------- 106 
CCX73726       511 --D-----DG-----------KG---ALK-AEVIYP-----DGNPLKIMNRYK 536 
57_pfamImport  109 --Dnn--nSTltvttrvtkvkDGqevIVDeQEVTTGev-gqKKATISFVNTYN 156 
44_pfamImport  116 svDtgdgtAA------------G------------------KSASLTFHNVKK 138 
47_pfamImport  115 tcSkitkyNS-----------AGtg---------------tTASEVVFNNTTV 141 
WP_012876932  1563 --D-----SL-----------EA---ELG-AEVSYGgg------frEFVNTYA 1587 Xylanimonas cellulosilytica
58_pfamImport  101 --D-----KK-----------NG---TLE-AAVVEG-----ESENLTFINTYG 126 
CDC54989       138 --N------------------DGd--TLKvDSITANdg-etKVSDMSFDNTYV 167 
WP_012797229   162 --DtgvaiKAvtfeknpsatsNGek---------------vDGGDVKFENTFV 197  Slackia heliotrinireducens
61_pfamImport  108 --N-----TE-----------NGg-tEVE-KITASNta-gdKVSEMNFENIYI 139 
60_pfamImport  107 --------DE-----------NG---ELK-AETAYYngegaDTDAAAFVNLYT 136 
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