Conserved Protein Domain Family
TORC_M
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pfam12885: TORC_M (This model is not part of the current CDD release)
Transducer of regulated CREB activity middle domain
This family includes the region between the N and C terminus of TORC proteins. TORC (Transducer of regulated CREB activity) is a protein family of coactivators that enhances the activity of CRE-depended transcription via a phosphorylation-independent interaction with the bZIP DNA binding/dimerization domain of CREB (cAMP Response Element-Binding). Although the C- and N- terminal domains of these proteins have been well characterised, no functional role has been assigned to the central region, yet.
Links
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Statistics
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PSSM-Id: 520504
Aligned: 19 rows
Threshold Bit Score: 156.438
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_040027490  144 RTNSDSALHQSTLAPSQQASFtGGSQELQP-----------------KRVLLLT-----VPGAEATKQETDENGQNQNWE 201
XP_005454043  144 RTNSDSALHQSAMNPKPQEVFaGGSQELQP-----------------KRVLLLT-----VPGTENSETSADKDMQKQLWD 201
XP_049321760  144 RTNSDSALHQSAMNPAPPDTFvGGSQELQP-----------------KRVLLLT-----PPDTEEPETEMENDDQKASM- 200
7_pfamImport    1 RTNSDSALHQSTMNPTPQDGFsGGSQDLQP-----------------KRVLLLT-----VPGTDEQESEADKNLQNQIWD 58 
10_pfamImport   1 RTSSDSVLHTSTMCPSPLDTYpGPAPTRVLpisheg---------fldseMGSK-----VPSIEENLLNGKHLL--KPWD 64 
XP_007233417  174 RTNSDSALHTSVMNPPAGDPFsAGH-TLNPqgrrsg-----lnegdgRRMFPYP-----VPPIEENVLDEGKLL--KPWD 240
8_pfamImport    1 RTNSDSALHTSVMNPNAQDAF-GSGPGLAPqnrhsvgliegdgrkskPSVICFL-----LPRF------LNRGVALQWMY 68 
2_pfamImport    1 RTNSDSALHQSTMTPAQQESFsGGSQDMQQ-----------------KRVLLLT-----VPGMEETTSDADKSLSKQGWD 58 
XP_035142228  148 RTNSDSALHQSTMTPTQPESFtSGSQDVHQ-----------------KRVLLLT-----VPGMEETTSEADKNLSKQAWD 205
XP_014351659  140 RTNSDSALHTSVMNPNPQDPFaGAS-QGMSqsrrsg---------qldgeMDNKaflfpVPPIDENLLDAKKF------- 202 coelacanth

XP_040027490  202 CSKNNS---RSEPCEVPGINIFPSPDQQ-MTTSLKPAA-------------HNTGGSLPDLTNIQFPPPLPTPLDSDD-- 262
XP_005454043  202 DKKDDSs--KPNTCDVPGINIFPSPDQE-LNPSVLPAA-------------HNTGGSLPDLTNIQFPPPLSTPLDPEDtv 265
XP_049321760  201 ---------HPKSHDVPGINIFPSPDQE-VNTSLMPAT-------------HNTGGSLPDLTNIQFPPPLPTPLDPDDpv 257
7_pfamImport   59 NKKNASa--RPKSCEVPGINIFPSPDQE-TTTSLIPAA-------------HNTGGSLPDLTNIQFPPPLPTPLDPEDa- 121
10_pfamImport  65 AKKLSSsssRLQSCEVSRVNISLSPDQP-ATVPVLLPA-------------MNTGGSLPDFITLYFPPPLPT-MDPEEt- 128
XP_007233417  241 TKKLPIltsRPKSCEVPGITIFPSPDQQ-SNAPHVPSA-------------LNTGGSLPDLSSLHFPSPLPTPLDPDEp- 305
8_pfamImport   69 TSRVPMlssRPKSCEVPGINPFSPSGCP------LPPSsavlsvgdrcglrVSTGGK-------HFQPPLPTPLDPEEp- 134
2_pfamImport   59 TKKAGSs--RPKSCEVPGINIFPSAEQEgGAAALVPAA-------------HSTGGSLPDLSNIHFPSPLPTPLDPEEa- 122
XP_035142228  206 TKKTGS---RPKSCEVPGINIFPSADQE-NTTALIPAT-------------HNTGGSLPDLTNIHFPSPLPTPLDPEEp- 267
XP_014351659  203 ----TTastRPKSCEVPGINIFPSPDQT-ASIALLPAA-------------LNTGGSLPDLTNLHFPSPLPTPLDPEEs- 263 coelacanth

XP_040027490  263 -AASASFSSSSGAQTLANTQGGNTSE 287
XP_005454043  266 aFPSLSAANSTGSLTTNLTHLGISAA 291
XP_049321760  258 sFPTTSTSSSTGNLTTNLTHLGISAA 283
7_pfamImport  122 sFPALSASNSTGNLAANLTHLGISTA 147
10_pfamImport 129 aYLSLSGGNSPSSLAHTMTHLGISGG 154
XP_007233417  306 gYPSLSGGNSTGNLASTLTQLGINTT 331
8_pfamImport  135 pFPSLSGGSSTGNLASTLTQLGINPG 160
2_pfamImport  123 pFPALSSSGSAGSLAANLTQLGIGSA 148
XP_035142228  268 tFPSLSGSSSTGNLAANLTHLGIGGA 293
XP_014351659  264 aFPSLSGGNSTSNLANTMTQLGISGS 289 coelacanth
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