Conserved Protein Domain Family
NUT

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pfam12881: NUT (This model is not part of the current CDD release)
NUT protein
This family includes the NUT protein. The gene encoding for NUT protein (Nuclear Testis protein) is found fused to BRD3 or BRD4 genes, in some aggressive types of carcinoma, due to chromosomal translocations. Proteins of the BRD family contain two bromodomains that bind transcriptionally active chromatin through associations with acetylated histones H3 and H4. Such proteins are crucial for the regulation of cell cycle progression. On the other hand, little is known about NUT protein. NUT is known to have a Nuclear Export Sequence (NES) as well as a Nuclear Localisation Signal (NLS), both located towards the C-terminal end of the protein. A fused NUT-GFP protein showed either cytoplasmic or nuclear localisation, suggesting that it is subject to nuclear/cytoplasmic shuttling. Consistent with this possibility, treatment with leptomycin B an inhibitor of CRM1-dependent nuclear export resulted in re-distribution of NUT-GFP to the nucleus. Inspection of NUT revealed a C-terminal sequence similar to known nuclear export sequences (NES) which are often regulated by phosphorylation. This family carries some natively unstructured sequence.
Statistics
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PSSM-Id: 520503
Aligned: 9 rows
Threshold Bit Score: 882.252
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_225188    116 MTVNAGATMSTFATLPVLPPAPQPAPQlfw-eppAPLMTAGISPRNPLVLS-ALPGMSLVAEDG---STALNAAVPLNIV 190
2_pfamImport   1 MIPHPGTAPSLVMLLPFPQPTHGPAPQppwgqphPPLLNVAFPPGSRLVLPaAIPRMPAVAGDGg--CGPNGAGNVHLLL 78 
4_pfamImport   1 MTLNPDASTPPFIALPFHPPGHGPAYRppwgqqlPPLMTAVFPPRSPLVLS-TLPKTPLVAGDSahcHCPSGAEALSVIL 79 
5_pfamImport   1 MILNPDASMPPFTALPFHPPGPSPALGpprgqqpPPLMTAVFPLGSPFLLS-TLPRTPLVAGDGt--CGPSGAGAFSVIL 77 
6_pfamImport   1 MTMKPGATLSPFTALPFPSSTPGPPDQppwepppQAPMPPAFSPGNPLVLS-AFPSPLLVTGDGg--PCPSGAGAGKVIV 77 
1_pfamImport   1 VAVTPGASLPPFRTMPFPPPIPGPQHWppweqhlPPSMTPSFPPGGTQLLP-AFPRTPLVPNAG---YGPSAPGACNIIV 76 
XP_014591075  14 VTMNPGASMSPFSALPFSPPTPGPPHQpswqqhpLPLITPSFPPDSPLVLP-TFPRTPLVATSG---HSPGGTGACNVIV 89 
3_pfamImport   1 VTLKPGASFTPFTAQPFPPPTTGPAHRppgeqhlPPLRTPSFPPGRPLVLP-ALPRTPLVAGDAg--QGPVGPGACNIMD 77 
Q5VT03        64 VTANPGTSLSVFTALPFTTPAPGPAHG-------PLLVTAGAPPGGPLVLS-NFPSTPLVTEQDg--CGPSGAGASNVFV 133 human
XP_225188    191 PLGTLGRPVQPVHNANIVLTQVPLNYNIPGAQGVGMGYSTPLFMATPAANTFIN------TRIASAVQPQEGTWVLGPR- 263
2_pfamImport  79 QLRTGGQPVEPLHSQTLVYNQTRISLNAPEGFCGAGQNPAPIAVPGSSLHATVP------APTMAGTQASQGGWPLGLP- 151
4_pfamImport  80 QVKSEGRSVQAVPTQTFVLPQAPLKWSASGALCRGAPNPVPLLLTAPPG-----------VPVTGGAPTSIGGWITGLP- 147
5_pfamImport  78 QVRSEGELVQAPPNKTFVLPQAPLNWSAPGAFCTGAQGQAPLLLSAPPVETIMPapiigsAPIVGGISASVGGWITGLP- 156
6_pfamImport  78 KVKTEGGPAEPSQTQNFFLTQTALNWIASGAPCGGPEDPPPLFVTASNMKTILP------TKAVGTP------------- 138
1_pfamImport  77 QVRSEGRPAEHPQTQTFVLTQAPLNWSTPGPLSRSTACPVPLFLTTPAMETIVT------APAVGVAQSGKGSWTPGFP- 149
XP_014591075  90 QVRLEGRPAEPPQTQNFVLTQASLNWSAPGALCGNAAYSATLFLAASVVETTVP------APAVGGTQAGKAGWSPGLP- 162
3_pfamImport  78 QVRSEGGRPQPSQTQTIVLTQAPPNWNAPGTTCGGAVCPAPLFLEASAVETIMP------ASAFGGTQASDGGWCPGLP- 150
Q5VT03       134 QMRTEVGPVKAAQAQTLVLTQTPLVWQAPGALCGGVVCPPPLLLAAAPVVPVMA------AQVVGGTQACEGGWSQGLPl 207 human
XP_225188    264 PPTTQQVVQLVPVRSPVTSAPPPKGAYGESVPANIQARNsPENYLSKPDSVYGNFRRWQHIKTLVQRHLPQTPDVAAFSC 343
2_pfamImport 152 PPTPPPSAQLAPMVFPVNNGPPPQGADRERILPTPKAQA-SPDNPYNSTSVYENFRRWQHFKALARRLLPQSPDTEALSC 230
4_pfamImport 148 HLVPPLAAHLTPNVSPVNTRPQPYRECRESSLPLS-----TRDDSCNAKSVYENYQWWQHFKSLAWRHFPQSPDTEAFSC 222
5_pfamImport 157 RPVPSPATHLAPVVSPVNTGLQPHGMCREGSLPTSQAKA-LQDDSCNPKSVYENYRRWQHFKSLARRHFPQNPDTEAFSC 235
6_pfamImport 139 PQVSPPVAQLAPIVPLEKAWPGLHGTTGEGGLAAIQSKPsLGDLSYTSKGVYENFRRWQRYKALARRHFPQSPDAEALSC 218
1_pfamImport 150 PQAPLPAAQLAPIIPQVNLGPQLHGISREGSLATNQSKA-SQDDSCNPKSVYENFRRWQRFKSLARRHLPQSPDAEALSC 228
XP_014591075 163 PRAPPPASQLASTTPPVNAGPHPHGASREGGLATSACKA-SLDDSCTPKSVYENFRRWQRFKSLARRHHPQSPDTEALSC 241
3_pfamImport 151 PQAPPPAAQLAPIVPSVNA-----GAPRKGVLATSQSKT-SPDDSCNPNSVYKNFRRWQRFKALARRHLPQSPDAEALSC 224
Q5VT03       208 PPPPPPAAQLPPIVSQGNAGPWPQGAHGEGSLASSQAKA-PPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSC 286 human
XP_225188    344 FLIPVLRSLARRKPTMNVEEGLWRGLQEWQCTSNYDRMIFFEMAEKFTEFENAEEMENS----MRNIQYQVLATAPRQDP 419
2_pfamImport 231 FLIPVLRTLAQRRPTMPLEEGLRFALREWQHKSNFDRMIFYEMAEKFMEFEEEEEIQMQklewMKGKPCQPPLVSPALLP 310
4_pfamImport 223 FLIPVLRTLARLKPTMTLDEGLWRAVQEWQQKNDFDRMIFYEMAEKFMEFEAEEEMQLQqlkwMKGSNFLPPSAPCRPSP 302
5_pfamImport 236 FLIPVLRTLARLKPTMTLDEGLWRAVQEWQQKNNFDRMIFYEMAEKFMEFEAEEEMQLQqlqwMRGSQSLPPPTPPRPDP 315
6_pfamImport 219 FLIPVLRSLARLKPTMTLEEGLPRAVQEWERTSNFDRMIFYEMAEKFMEFEAEEEMQLQnsqlTNGSQGLSPAASLKLDP 298
1_pfamImport 229 FLIPVLRSLARLKPTMTLEEGLWRAVQEWQHRSNFDRMIYYEMARKFMEFEAEEVMQIQklqwMQGVQGLPPPVPPKLDP 308
XP_014591075 242 FLIPVLRSLARLKPAMTLEEGLWRAVQEWQHKSNFDRMIFYEMAGKFMEFEAEEEMQIQklqwMKGARGPPPPAPPRPDP 321
3_pfamImport 225 FLIPVLRSLSRLRPTMTLEEGMWRAMQEWQRKSNFDRMIYYEMAEKFMEFEAEEQMQIQklelKKGAHTQPTPAPPRPDP 304
Q5VT03       287 FLIPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQksqwMKGPQCLPPPATPRLEP 366 human
XP_225188    420 PRLPAPKAVKEPECTS-----------------------------------MKTVPRTdsaHLPEFRHQq-LRKAKTPTE 463
2_pfamImport 311 QGPPAPVAVQQPGTVSrvpthpctht----------------mfpstgcapRKASSKAlpaCPVPPRHQ--GPQDKTPKE 372
4_pfamImport 303 QDSTASEVVQQPGLHPllssvaswptaapa--------apssylltsvvlpRKVGNKp---HIPPPTPDwqLPENKAPKE 371
5_pfamImport 316 QEQPGTKVVQHPGATGeqkrkgpgrpldlppkf-yskeflslsprppqcgvRKADTKAqpiHLPPPTPQqwPPEIKAPKE 394
6_pfamImport 299 PGPLTPEVCQQSVYIP-----------------------------------KKAASKArapRRRQRKPQr-PPVPEAPKE 342
1_pfamImport 309 QGSSAPTVCPQPGTHVptgvpskgdmgqgmtagpipspsfplscsasasapRKAGPRAhptRSQPHRAQr-HPGTKAPKE 387
XP_014591075 322 QGPPAPEVGLQPVAsac--------------------------------tpRKAGPRGqpaRPQPHRPQr-RPESGAPKE 368
3_pfamImport 305 RGPPAPVVGGQPGGsfipsrsll-------------------fplcpartpRKALPSAqhiR----RHQr-PQETKSPSE 360
Q5VT03       367 RGPPAPEVVKQPVYLPskagpkaptaclpppr---pqrpvtkarrppprphRRAETKA---RLPPPRPQr-PAETKVPEE 439 human
XP_225188    464 IPPEAVQEYMDIMDWLEGFPQPFAGDPKEKEEDENSGTEQEGDDLYSDAGLLSYIDELCSQKRFVEQVEAIINPQFVAEI 543
2_pfamImport 373 IPPEAVKEYMEIMDTLLGPTPLSLEPPDGHPEEDRDEGFLENEGSYPDPEMLSYIDHLCSQVDFVTKAEAIIHPRFLEEL 452
4_pfamImport 372 IPPEVMKEYLKIMDKVLGPPCGDSGELDTQLEEGKAEPPQYEAGTIPDPRFLCYIDKLCTQEDFITKVEAVIHPRFLEEL 451
5_pfamImport 395 IPPEAVREYIDIMDKLLGPPCGDLGKPDAQLEEGEADQSQDEFGIYPDPGLLSYIDKLCSQKDFITKVEAVIHPRFLEEL 474
6_pfamImport 343 IPPEAVKEYADIMEGLVG-SHSATGEPEGKQEEEEEQ-QQEEEGMYPDSGLLSYIEDLCSQEIFVSKVEAVIHPQFLADL 420
1_pfamImport 388 IPPEAVREYVNIMEVLVGPIHLATGKSEAECGKDEDELKQEEDGTYADPDLLSYIDKLCSQEEFVTKVEAVIHPRFLADL 467
XP_014591075 369 IPPEAVREYVDIMEGMLGLARPATRELDGGRKEDRNERQQEGGGVYPDLGLLSYIDKLCSQEDFVTKVEAVIHPRFLAEL 448
3_pfamImport 361 IPPEVVREYMDIMDNLLGLPHSATEAPGGGWEDEVKEWLQ-------DEGLLSYLDQLCSQEDFVTQVEAVIHPQFMEQI 433
Q5VT03       440 IPPEVVQEYVDIMEELLGPSLGATGEPEKQREEGEVKQPQEEDWTPPDPGLLSYTDKLCSQKDFVTKVEAVIHPQFLEEL 519 human
XP_225188    544 LSAKPEMDILALTKELEHEEELTIDQLIEKHClALKKKGVERAALNPGDPQNPANASVLPACQGAQ-RDDCGAQKGASTQ 622
2_pfamImport 453 LSPDPQLDLTALPKELEKEEGLTADQVMAKHC-SLKEDGAVGATPSHGVPQLNPSNSESGPQQSAQ-SDNQGPRLGDRAE 530
4_pfamImport 452 LSAETNMDSLALTQELEKEEGLTLDQMVEKRLlALKEEQSMGAAQSYQALWVNSSASKSAAGHGTK-NNSHRPKLEIVAE 530
5_pfamImport 475 LSPETNMDSLALTQELEQEERLTLDQLVEKRLlALKEEQSVGVTLSRRALQMESSPSKLAAGQGAE-RDSHGPKLGVGAE 553
6_pfamImport 421 LSPEQQRDPLALIEELEQEEGLTLAQLVQKRLlALEEEEDAEAPPSCSGAQSDSSPSVSGKTGKRSaQELRDPWLGVSED 500
1_pfamImport 468 LSPEPQLDPLALAEELEQEEGLTPEELVQKRLlALKEDKGVRTPSSQSVPQVDSSPSESDASKDAQ-RYDQGPQLGVRHE 546
XP_014591075 449 LSPEPQLDPLALAEELEQEEGLTTEQLVQKRLlALKEEEGVQRPPSHSAPPLDSSPSESEAGPDAH---DHDPQLGVSDQ 525
3_pfamImport 434 ISPDTQQDPLALAEELEQEEGLTAAQLVEKRLlTSK-EGGVQAPPSHSAPLLNSSSSESEIGQDAQ-RRDRGPQLGVSDK 511
Q5VT03       520 LSPDPQMDFLALSQELEQEEGLTLAQLVEKRLlPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAE-RDVPDPQQGVGME 598 human
XP_225188    623 TASSRMASLDQQCLGGTNTELWGPKPATLHPSNQSSPSLVDngstgfpcgrgahnqspgSRCAGILRGTSATEDPQGPLG 702
2_pfamImport 531 CYSWSMPSQDLQRHAVPDTPLCRPEVNAVFSGHRECPSLGA------------------TKDARSFRGGPSVEGPHTPLD 592
4_pfamImport 531 TYPAQMVSHAPQGHGRVKDDLPRPKAPGLLSWHAESPRLRAtqptspfqglslttpglgTRDASGLQGASPVRETFRQED 610
5_pfamImport 554 TCPAQMASR-AQGHSRMQADLLRPKARGLLSGHPESPRLRAtlptspfqglkptslglgTRDALGLQGASPVRETFGPGD 632
6_pfamImport 501 TCLPNFNSYDLQGEGREDADLSKPKDNVPLDGRQESYALETpktisshqdqgstfptqeTKDALVLRENPPVSEICSSAD 580
1_pfamImport 547 AGPPEVDFEAVHRFSQANTGLSKAKDLVPSLGQQELPPFQPgqpsppqgq-rctgpqpgPRDTSVLRTVFPILGARGPRD 625
XP_014591075 526 AYPPETDCEDAQRPGQADTDLPRPQALALSPGRQESPPLGAarppsppqaprltsptlgSRDAPVLREASPARETHRPAD 605
3_pfamImport 512 AWPPETDFKDQQRRGPADAHRPRPQASAVSAGRQEHPPLRArcppsapqghrpaycalgSREACVPREASLVRETLEP-D 590
Q5VT03       599 TCPPQTTARDSQGRGRAHTGMARSKDSVVLLGCQDSPGLRAarptsppqdhrptcpgvgTKDALDLPGGSPVRESHGLAQ 678 human
XP_225188    703 KT---------IEDKeELHSLSFLLSSQYRLVPWRLSPQMCPYADLPDSAS-----IPKP-CPKMRGPSPDPCPIVKSKK 767
2_pfamImport 593 IS---------SENEeELPSLSFLLASQHHLLPLGFAQSEASAEDLPCLGAgnpcrAPKPlSTHLRDPRGPLPHAAKSRK 663
4_pfamImport 611 GS---------SEDEeELPSLAFLLASQHRLLPWGLSQNPVPG---------------QPpSAQRRGFSPAAPPMAKSSK 666
5_pfamImport 633 GS---------SEDEeELPSLTFLLASQNRLLPWGLSQSPVPV---------------QPpSAQRRGLSSATLPVAKCNK 688
6_pfamImport 581 GAkeeekqeeeDEEDeELSNFAYLLASKLSLSPKQLPLG------------------THLlCPEARGLSQPPYPVVKSGK 642
1_pfamImport 626 GS---------SEDEeELPSLAFLLASQHSLLPWRLSQSPVPASG-------------QApSSQRIGLSPAP-------- 675
XP_014591075 606 GS---------SEDEdDLPSLAFLLASQHSLLPWRLSQSPAPASGLLCPGGqgaqgAPQApSPQSTGLSPAPPAAAESWK 676
3_pfamImport 591 RS---------SEDEeDLPSLAFLLGSPNSLLPCGLSLSPVPASGLACPGGrgprgAAQSqFFQTLGLTRASPAASKSRK 661
Q5VT03       679 GS---------SEEE-ELPSLAFLLGSQHKLLPWWLPQSPVPASGLLSPEKwgpqgTHQSpSAERRGLNLAPSPANKAKK 748 human
XP_225188    768 RAVFGGLVPTAKKPNLEPGFGVSEEPLSALELVHLSQTQKRNHETLGT-RKRKRK 821
2_pfamImport 664 QALQGGQGPAIKKPCPVPQLRASGGQAQALGSVGNSQAQKRKHDHLVTrRRKKHH 718
4_pfamImport 667 QVICGYRLPAERMAYPGSQLRVSGAKPLALRSGQFLKPQKRRSDPFFSgTEKKQC 721
5_pfamImport 689 RVLSGDQFHAEKMASPGPELGASGGEPLALGPGRSSQPQKRKGDSFVSgMKKKQR 743
6_pfamImport 643 RVLAKGLAPAEKKSHSGVQLGVSGEKTLALGVVRPSQPRKRRRDSFVTgRRKKRR 697
1_pfamImport 676 ---------------LGAGLGVSETPALALGLVRSSQLRKRKCDPFVTgRKRKRL 715
XP_014591075 677 RPVCAGPAPAEKMPLPGAKLRVPGRSALALGLVRPSQPQKRRCDPCVTgRRRKRH 731
3_pfamImport 662 RALAGGLAYAEKTPRPGANLGVCGRPVLALELVCASQPQKKKDDPGCStHKRNRD 716
Q5VT03       749 RPLFGSLSPAEKTPHPGPGLRVSGEQSLTWGLGGPSQSQKRKGDPLVSrKEKKQr 803 human
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