Conserved Protein Domain Family
SICA_beta

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pfam12878: SICA_beta (This model is not part of the current CDD release)
SICA extracellular beta domain
The SICA (schizont-infected cell agglutination) proteins of P. knowlesi, one of the variant antigen gene families, are associated with parasitic virulence. These proteins are comprised of multiple domains, with the extracellular domains occurring at different frequencies. There can be between 1 and 10 copies of this cysteine-rich domain.
Statistics
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PSSM-Id: 520502
Aligned: 66 rows
Threshold Bit Score: 133.229
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002262011  938 TLCDGLQCIASHLNSPNAKT---KIP-SVd--kFW----DKTGEVADLWNTLSKEMTDKGKNGSVAe-CNTMDDGsatgg 1006
XP_002259511    8 NLCDRADCVADRWIK--Nrnqggt---aktydnMWrdddGVEEELKNLSAALS-S-----GGTNGDtlCNHINGSg---- 72  
XP_002261960  931 TLCDYIRCAAPKWFKNKNGtngnsk---hswcdFWee-vGVKPELVKMFTAIRTNGNNKSKQTNVV--CDQFGDDn---- 1000 Plasmodium kn...
XP_002257731 1163 NLCDYIRCAAPKWFKNKNGnngnpt---qswcnFWd--dAVKTTLQKMFQQISQNGTANATNNNGV--CDQFGDGn---- 1231 Plasmodium kn...
XP_002258014  296 KLCNRLQCIDDYLKATKGqtvaaag-qtttaaaLWn---DVQTQVTKLATTVSNN---VGSDSDADglCKDVKCPn---- 364  Plasmodium kn...
XP_002260171  297 KLCHRLQCIDNYLKATGAaeaeaaarktststdIWk---EVRTQVTELVTNVEKN----NDNTDADtlCNDITCPn---- 365  Plasmodium kn...
XP_002259345  340 KLCSRLDCMKQLWNNKGGqtsd--------adaLWk---EVREQVTNLVTKVSDK---GTSDSDAEtlCSTVQCPn---- 401  Plasmodium kn...
XP_002262011  295 eFCKRLECVLRKKRGLDGnsantt----tkddkVQe---EVKAEVTSAATNISTS---GTSDTDVDqyCSTVQCTn---- 360 
XP_002259663  940 gLCGRVECVKKQWLEDRGhdksnk----tkeneMWt---EVQKEVTKLDSALSDN---GGSDGDVDslCSAVTCTn---- 1005 Plasmodium kn...
XP_002259663  727 dLCKRFQCVSERWLKQEKANkggTVE-PSdwkkVWd---AAKNELTTLGKDINS------KKKEVHeyCKDLGSH----- 791  Plasmodium kn...
XP_002262011 1007 tangRPATKPEKKACNYLHAGFEKLkq----lsKPSTPQTQNGKildENPLLRQTVGCFLLKEYAKQMQSKS-----KCV 1077
XP_002259511   73 ----KEVSEEEKTVCKFIAAGLESIyeik-akvdSKGNITKKAL---EDQLFERTMRCVLLNAFADKL--EAlpcadENK 142 
XP_002261960 1001 ------PDSVERRACNHITAGLDYIkk----ipNGAASKQSNGQ---DNQLLQRAVGCIALNMYADKIRDes---dkVCP 1064 Plasmodium kn...
XP_002257731 1232 ------EHSVERKACNHITAGLQHIkaipndsgSGSTTTPSIGQ---DNQLFERTVGCIALNMYADKIIKet---ekSCP 1299 Plasmodium kn...
XP_002258014  365 ---dGEEECVSKTTCNIMAKALKEVyk----------kGEADQE---DYRIFYPTLRCVILNAFADKLKDRAneggyACA 428  Plasmodium kn...
XP_002260171  366 ---gGANDCVSKTTCKIMAKALKEVhk----ngDDDTNLGPLKV---NNPIFRPTIRCVMLNAFAEKLKQHAqgkgyACA 435  Plasmodium kn...
XP_002259345  402 ----GSADCVSKTTCNIMVKALKEVht----------vGETGQE---DYRIFSPTMRCVILNALAEKLKEQAykggyACA 464  Plasmodium kn...
XP_002262011  361 ---gNADGCVSKETCKIIVKALKEVhk----igKGGQGSDGDKE---INRIFKSTIHCMALNAFIQKLKQQAdqggyGCA 430 
XP_002259663 1006 ----GAKDCVSKTTCKLIVRALKDIhqi---kkEDGSGSEGAKL---NDRIFKSTMRCVILNALAEKLKQHAkqggyACA 1075 Plasmodium kn...
XP_002259663  792 ----GDGRPRDKEACLRIAAGLKNLyd------iKDGNEVEKS--------FKRTMQCVLLNAVADRLMGlrc--kgERS 851  Plasmodium kn...
XP_002262011 1078 I-EAGLKSAFNSW-NSSNNGn----C--SGTEPCVPCQWndaNIDECKI 1118
XP_002259511  143 I-KDAIDKAFG-KsSVIMGAts--pCk-SDGDKCFTCERk-aNF-SCEI 184 
XP_002261960 1065 IgEEKINKMFEEWnNNNNSSsstpcngvSGTNSCFKCTRe-kDFNSCDL 1112 Plasmodium knowlesi strain H
XP_002257731 1300 IdENTIKRMFEEWnNNNKSLcn----sgSNNNGCFKCTRe-kDFKDCNL 1343 Plasmodium knowlesi strain H
XP_002258014  429 V-EEGIEGAFAAA-QEKNKYke--wCn-GNGKNDGSCQP-------CGK 465  Plasmodium knowlesi strain H
XP_002260171  436 V-EEGIEEALKKG---EGKRke--wCkeGSGKEDGPCEP-------CGN 471  Plasmodium knowlesi strain H
XP_002259345  465 V-EDGITKAFEVG---GTQHst--wCg-DKRKGDGSCQP-------CGK 499  Plasmodium knowlesi strain H
XP_002262011  431 V-QRGIDKAFDEK-NLKNKRke--wCg-KSSNVDGSCEE-------CGK 467 
XP_002259663 1076 V-EEGIKGAFVAA-GKEENRkk--wCkeNGKKDDGSCEE-------CKE 1113 Plasmodium knowlesi strain H
XP_002259663  852 V-VEGITKAFD-NsESIKDKsv--nC---KGDKCFKCERf-kEYSRCYI 892  Plasmodium knowlesi strain H
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