Conserved Protein Domain Family
KIAA1549

?
pfam12877: KIAA1549 (This model is not part of the current CDD release)
UPF0606 protein KIAA1549
This family contains KIAA1549 from human which has been implicated in pilocytic astrocytomas. It has been found to be fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. The BRAF protein is a well characterised oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion. More recently, KIAA1549 has been described to play a role in photoreceptor function.
Statistics
?
PSSM-Id: 520501
Aligned: 9 rows
Threshold Bit Score: 842.963
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_023206243  825 NQTTPDQKYQVHTVLQFIPGHVDMRYCSFFESVEKGLIMAFAEVWRRSKESTN-FTIHILNITTAtnrygekqltRQPVD 903 
Q6ZVL6        931 WNPQPAGYFQLKTVLQFVSQADNIQSCKFAQTMEQRLQKAFQDAERKVLNTKSnLTIQIVSTSNA----------SQAVT 1000 human
XP_015208727 1000 VMGVPDHQFQVHSVLQFVPSYIDVRFCNFSERIEKGLIMAFSEVRRRYQESPD-FIVHIINITMNlpkaq-kqlqRVPVD 1077
6_pfamImport    1 LYSVPELRYQVHTVLQFVPAHVDVRVCNFSERIERGLLLAYGE--RRSQEGRD-VSVQLLNVSALqvaa---arlKLSVD 74  
XP_029698179  773 NWTTPDRKYHIHTVLQFVPGHIDVRFCNFSESIEKGLTMAFAEVRRRSKESTN-FTVHIVNITMAaqqyyeqqpqRKPVD 851  torafugu
XP_064418037  878 AAEVPEYWFQVHTVLQFVPYNVDVRFCNFSQRIERGLSLAFSEVKRRYMEKTS-IIVQLLNITLSvtep--evyrKGPVN 954  coelacanth
XP_006499550  383 WKPQPAGAFQLKTVLQFVSQSDNIQSCRFAQTMEQRLQKAFQDAERKVLSTRSnLTVQIVSTSNA----------SQAVT 452  house mouse
XP_015141811  470 WKPLPAYHFQLKTELQFVSQTDNIQSCRFVQTMEQRLQRAFQDAERKVWNTSNnLTVQILNTSKV----------SQAVT 539  chicken
XP_005991308 1421 VFPSPAIWFQVKTVLQFVDSTDNIQLCSFVQTMEQGLENAYNDAEVKVLNTKSnLTVEilntskPd--------gSEAVS 1492 coelacanth
XP_023206243  904 ITFTVSGSRGYLMGSKVSNALMKLTMVEFSYYIGFPVLQIAEPFHYPELNTSQLLRSSWVRTVLLGVLDKKM--SERTFQ 981 
Q6ZVL6       1001 LVYVVGNQSTFLNGTVASSLLSQLSAELVGFYLTYPPLTIAEPLEYPNLDISETTRDYWVITVLQGVDNSLVglHNQSFA 1080 human
XP_015208727 1078 IIFAIRDSTGYLNGSEVSSLLRNLNMVEFSFYLGFPVLQIAEPFHYPELNVTQLLRSSWVKTVLLGVMEQRV--NERTFQ 1155
6_pfamImport   75 ITFAVRDGRGYLLGSDVSEHLRKLSLVEFSFYLGFPVLQIAEPLHYPELNTSHHLRSTWVRTVLLEVPEQQV--AERSFR 152 
XP_029698179  852 ITFTVRSSRGYLTGSEVSNALMKLTVVEFSYYMGFPVLQIAEPFHYPELNTSQLLRSSWLRTVLLGVMDHKV--GERTFQ 929  torafugu
XP_064418037  955 ITFAIRDGDGYLNGSDVSDLFRLLNMVEFSFYLGFPVLHIAEPFHYPELNLSHTLKSSWIKTVLLGVLDYRL--KQKAFQ 1032 coelacanth
XP_006499550  453 LVYAVGNQSSFLNGTVASSLLSQLSAELVGFYLTYPPLTIAEPLEYPNLDTSETTRDYWVITVLQGVDNSLVglHNQSFA 532  house mouse
XP_015141811  540 LFYVVNNQSTTLNGTISSNLLNQLSAELVGFYLTYPPLTIAESLEYPNLDVSESTRDYWVITVIQGVDIALLglNNQSFA 619  chicken
XP_005991308 1493 LIYVVKNHTMMLNGTVSSNLLNRLSAELVGFYLSYPPMIIAEPLEYPSLDTSSATRDYWVITVILGVDNASLgaNYQSFA 1572 coelacanth
XP_023206243  982 ANMERRVALLLGEAMGQV--RRVKRATTVGNSSVQVLSVSRLEGADNPAEMVYFVEgHNGQRMPAVQTANLLNSLDVQRA 1059
Q6ZVL6       1081 RVMEQRLAQLFMMSQQQG--RRFKRATTLGSYTVQMVKMQRVPGPKDPAELTYYTL-YNGKPLLGTAAAKILSTIDSQRM 1157 human
XP_015208727 1156 AKMERRLAQLLGEVLGSA--RRWKRATNVGNNSVQIVRTTRLDGPDNPLEMIYFVEgPNQERLAATTTSSILNQINVQRA 1233
6_pfamImport  153 ARLERRLALLLQEGLRASsrRRWRRATAAGNHSLQVARVAMLGGAERPLEVFYFVEgPGGERIPAEAAAAAINGVDPQRA 232 
XP_029698179  930 ANMERRVAMILGEAMGSA--RRVKRATAIGNSSVQVVSTSRLVGTDHPLEIVYFVEgPDGQRMPADQAAYILNRMDVQRA 1007 torafugu
XP_064418037 1033 AEMERKLAQLISEVQGRV--LRRKRASTLGNSTVQIVTVSRIEGVDDPVELVYFVEgQDGGRLSAVEASHLFNKIDIQRA 1110 coelacanth
XP_006499550  533 RVMEQRLAQLFMMSQQQG--RRFKRATTLGSYTVQMVKMQRVPGPKDPAELTYYTL-YNGKPLLGTAAAKILSTIDSQRM 609  house mouse
XP_015141811  620 RLMEQRLAPLFMMSHQQG--RRFKRATTVGSYTVQMVKIQRIPGPKEPAELTYYTL-YNGKPLLGTAAAKILSTVDSQRM 696  chicken
XP_005991308 1573 GLMEQRLALLFDSTQQQA--RRFKRANTYNNYIVQMVNMKRVPGQKNPAELTYYAL-HNDEPLLGTTAAKILSTVDPQTM 1649 coelacanth
XP_023206243 1060 AIILGYRVQgVLAQPVekLASSpsdseNSNMWIVIGVVVPLLVVVIIISILYWKLCRTDKLEFQPDAMTTIQQRQKlqap 1139
Q6ZVL6       1158 ALTLHHVVL-LQADPV--VKNP-----PNNLWIIAAVLAPIAVVTVIIIIITAVLCRKNKNDFKPDTMINLPQRAK---- 1225 human
XP_015208727 1234 AIVLGYRVQgVLAQPVekITAPpsetqNNNLWIVVGVVVPVVVVVIIIIILYWKLCRTDKLEFQPDTMSNVQQRQKlqap 1313
6_pfamImport  233 AIILGHRVRkPVAQPAetAPVPpaethSSSIWLIVGVIVPILLALFIVVILYWKLCGSEKLEFQPDAVNAVQQRQKlqap 312 
XP_029698179 1008 AIILGYRVQgVLAQPVekVASApsdteNTNLWIVVGVVIPLLVVIIIISILYWKLCRTDKLEFQPDAMTSIQQRQKlqap 1087 torafugu
XP_064418037 1111 AIILGYRVRgTVAQPVekVEQPps-dtKNNLWIILGVAGPVIVVVIIIVILYWKLCRTDKLEFQPDTMSNIQQRQKlqas 1189 coelacanth
XP_006499550  610 ALTLHHVVL-LQADPV--VKNP-----PNNLWIIAAVLAPIAVVTIIIIIITAVLCRKNKNDFKPDTMINLPQRAK---- 677  house mouse
XP_015141811  697 ALTLGYVIQ-VQADPV--VKNP-----PNNLWIIAAVLAPIAVVTVIIIIITAVLCRKNKNDFKPDTMMNLPQRAK---- 764  chicken
XP_005991308 1650 ALTLGYIVQ-LQAEPI--VKNP-----PNNLWIIAAVLAPIAVVTVIIIIITAVLCRKSKHDFKPDSMGNMHQRTK---- 1717 coelacanth
XP_023206243 1140 SVKGFDFAKLHLGQQSKDD--VMVIQEPAlpgsgsaPLAQSIKDgFSpsENGEVPTPKSKTsasstKASR-GGRRReRIS 1216
Q6ZVL6       1226 PVQGFDYAKQHLGQQGADEevIPVTQETV-------VLPLPIRD-AP--QERDVAQDGSTI-----KTAKsTETRK-SRS 1289 human
XP_015208727 1314 SVKGFDFAKLHLGQHNKDD--ILVIQESA-------PLPAPVKE-VTpsESGDVPSPKSKAs---sKVSR-GAKRRgRIS 1379
6_pfamImport  313 SVKGFDFAKLHLGQHSKDD--MLVIQEPG-------PLPAPAKE-ATpsDAGDLNTPKSKSss--nKGAR-SGRRRgRLS 379 
XP_029698179 1088 TVKGFDFAKLHLGQHSKDD--VMVIQEAAppgtgsgPLPMPAKDgLSrsDNGELPAPISKNs---tKASR-SSKRHeRIS 1161 torafugu
XP_064418037 1190 SVKGFDFAKQHLGQHNKED--VLVIQEPS-------PQPLPVKD-ATpsENGNVPTPKPKTt---pKTSK-GIRHRgRIS 1255 coelacanth
XP_006499550  678 PVQGFDYAKQHLGQQGADEevIPVTQETV-------VLPIPVRD-TP--QERDTAQDGSAI-----KTAKsTETRR-SRS 741  house mouse
XP_015141811  765 PVQGFDYAKQHLGQQGAEDevLPVTQETV-------VLPLPVRD-APasQEREITQDGSTI-----KTAQsNDTRK-SRS 830  chicken
XP_005991308 1718 PVQGFDYAKQHLGQQGADEevVPVTQETV-------VLPLPVRD-APlsHEREIPKDGSTT-----KTAKsLEARK-SRL 1783 coelacanth
XP_023206243 1217 PSDGDSVVSDHSSEREPTEENP-RAHATPSDSK-QTRKNRIgppp--------mngaANEQLSSASIFEhvdRMSR-ATD 1285
Q6ZVL6       1290 PSENGSVISNESGKPSSGRRSPqNVMAQQKVTKeEARKRNVp---------------ASDEEEGAVLFD---NSSKvAAE 1351 human
XP_015208727 1380 PSDAESTVSEPSSGRESAEEST-RPSITPIDGK-QHRKTVRngpp--------qmngTEEPLSSASIFEhvdRMSR-TSE 1448
6_pfamImport  380 PSDGDSLGSDQSSARESAEESA-RAVATPTEGK-QHRRTPRngqkn-------lpstPDEFLSSTSIFDhvdRLSRgSAD 450 
XP_029698179 1162 PSDGDSVVSDHSSEREPNEENR-RGYTTPSDGK-HTRKVPInvlngknrigpppmngTNEQLSSASIFEhvdRLSR-GAD 1238 torafugu
XP_064418037 1256 PSDAESLGSEPSSGRESAEEEP-RPALAPSEGK--HRKEMKngpp--------vsngTDEQHSSASIFEhvdRNSR-SSA 1323 coelacanth
XP_006499550  742 PSENGSVISNESGKPSSGRRSP-QN-----GMT-QQKVTKEesrk--------rnvtASDEEEGAGLFD---SAGKaAAD 803  house mouse
XP_015141811  831 PSQNGSIISNESGKPSSSRSSPqKVVAPPKVTKdEGRKRNVp---------------ISDEEEGGILFD---NIAKsAID 892  chicken
XP_005991308 1784 PSENGSVFSNESGKPNSGGSSMqKITAQQKNTKeETRKKNAp---------------LSDEEEGAVLFDh---DSKnSLD 1845 coelacanth
XP_023206243 1286 ASRRLPNKVQLIAMQPMP----VPPLh----sQPVNGKPSD-PNQMNKEIQAALRHKSEIEHHRNKIRLRAKRKGHYDFP 1356
Q6ZVL6       1352 PFDTSSGSVQLIAIKPTA----LPMV------PPTSDRSQEsSAVLNGEVNKALKQKSDIEHYRNKLRLKAKRKGYYDFP 1421 human
XP_015208727 1449 ATKRVSNKIQLIAMQPMP----ASPLh----sTAVLEKVSE-TAKINKEIQTALRHKSEIEHHRNKIRLRAKRKGHYDFP 1519
6_pfamImport  451 GLRRQGNKVQLIAMQPQP----SPPHaasqpsPSLTEK-------------VALRHKSEIEHHRNKLRQRAKRRGQCEFP 513 
XP_029698179 1239 ASRRLPSKVQLIAMQPMP----LPPLh----gTPINDKLSD-ANQITREIQVALRHKSEIEHHRNKIRLRAKRKGHYDFP 1309 torafugu
XP_064418037 1324 ASRRVPNKIQLIAMQPIV----APPLq----kPLVLERVAE-SCKINKEIQTALRHKSEIEHHRNKIRLRAKRKGHYEFP 1394 coelacanth
XP_006499550  804 PFDTSSGSVQLIAIKPSAlpvvHPAS----------DRGQEsSAALNGEVNKALKQKSDIEHYRNKLRLKAKRKGYYDFP 873  house mouse
XP_015141811  893 PFDTSSGSVQLIAIKPVA----LPAV------HAASDRSQE-SAIINGEVNKALKQKSDIEHYRNKLRLKAKRKGYYDFP 961  chicken
XP_005991308 1846 PFDTSSGSVQLISIKPLT----APPSy----sHPASDRSQE-SAVINGEVNKALKQKSDIEHYRNKLRLKAKRKGYYDFP 1916 coelacanth
XP_023206243 1357 AMDDMvGSLSDTke----qDRIYQKAQTQIDKILDPDN-PVP-AVFMDSKKSGr--GRRSPKQRLKDQ-LNGGLIEADKD 1427
Q6ZVL6       1422 AVETS-KGLTER-------KKMYEKAPKEMEHVLDPDS-ELC-APFTESKNRQ---QMKNSVYRSRQSlNSPSPGETEMD 1488 human
XP_015208727 1520 AMDDI--GIVDSre----hRRIYQKAQMQIDRILDPEV-HVP-SVFIESKKSAr--GKRSPKQRRKHQ-VNGSLTDADKD 1588
6_pfamImport  514 SMDDImDAFGDGpvqgeaaQRLYSSAHDHMDCMVPSDG-PSP----TDSRRRSpcrGRSSPRGRRAQP-GLGSLPDTDRD 587 
XP_029698179 1310 AMDDLtCGLGNGkd----qDQIYQKAPTQ---IVDPEA-QMPmSIFTGSKKSGr--ARRSPKQRVKEQ-LNGGAREADKD 1378 torafugu
XP_064418037 1395 VMEDV--AFTDTkd----rRRLYRKAQMQIDRILDPNAhHAP-SISMEPRKSSr--AKRSPRQRRRHQ-MNGSLTDIEKD 1464 coelacanth
XP_006499550  874 PVEAG-KGLAE--------RKMYEKAPKEVEHVLDADP-ELC-APFAESKNRQ---QMKNSVYRSRQSlNSPSPGETEMD 939  house mouse
XP_015141811  962 QVDNN-KGLTDR-------KRMYEKNQKEIDHILDPDP-DVS-SPFAEPKNRQ---QMKNSIYRSRQSlNSPSPGETEMD 1028 chicken
XP_005991308 1917 QVDSNsKSLTDRq------RKMYEEAQKEIDKVLEPET-DGS-SPFTRPKNRQs--RMKNTVYKSRQSlNSPSPGGTEMD 1986 coelacanth
XP_023206243 1428 H---LITEDsdavyRKCPGVNNVAYv---SDPDQGPGSpqRSPSPTD-DVFLGPASSPPGHapPPPPYLPPQPSIEEARQ 1500
Q6ZVL6       1489 L---LVTRE-----RPRRGIRNSGYd---TEPEIIEET--NIDRVPE-PRGYSRSRQVKGH--SETSTLSSQPSIDEVRQ 1552 human
XP_015208727 1589 R---LITTDsdgtyKKPPGVNNVAYv---SDPDQAPEP--RSPSPQDnEVF--VGSPPPGHapPPPAYVPPQPSIEEARQ 1658
6_pfamImport  588 RdrdRLLAEqsatyRKYPGLNNVAYm---SDPDLPPDR--SSPSPSD-ESL--------TPrpPRRPTRPPGPPSRRRGS 653 
XP_029698179 1379 H---LISEDsegiyRRCPGVNNVAYv---SDPDQGQCSphRSPSPTD-DVFLGPTCSPPGHapPPPPYMPPQPSIEEARQ 1451 torafugu
XP_064418037 1465 R---LIATDsdgtyKRPPGFNNVAYigctSDPDVPIVS--QTPSPQDgEVF--PGSPPHGHppPPPPYIPPQPSIEQARQ 1537 coelacanth
XP_006499550  940 L---LVTRE-----RPRRGIRNSGYd---TEPEIIEET--NVDRVHE-PRGYGRARQAKGH--SETSTLSSQPSIDEVRQ 1003 house mouse
XP_015141811 1029 L---LVTRE-----RPRRGIRNSGYd---TEPEIIEET--NVDRVTE-PRSYTRSRQAKGH--SETSTLSSQPSIDEVRQ 1092 chicken
XP_005991308 1987 F---LVTRE-----RPRRGIRNSGYd---TEPELIEET--NIDRVAE-SRSYGRSRQGKGH--SETSTLSSQPSIDEVRQ 2050 coelacanth
XP_023206243 1501 QMHSLLDDAFALVSPTS 1517
Q6ZVL6       1553 QMHMLLEEAFSLASAGH 1569 human
XP_015208727 1659 QMHSLLDDAFALVAPTS 1675
6_pfamImport  654 SMHSLLDDAFALVSPSS 670 
XP_029698179 1452 QMHSLLDDAFALVSPTS 1468 torafugu
XP_064418037 1538 QMHSLLDDAFALVAPGS 1554 coelacanth
XP_006499550 1004 QMHMLLEEAFSLASAGH 1020 house mouse
XP_015141811 1093 QMHMLLEEAFSLASAGH 1109 chicken
XP_005991308 2051 QMHLLLEEAFSLASAGR 2067 coelacanth
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap